DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and CG8159

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	112/575 - (19%)
Similarity:	185/575 - (32%)	Gaps:	218/575 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IHTVCRTCLSTVDDSAAYDLFRVPGLAK---KLCVCTSLSVEQADGFPKNLCNVCFSKLNDLHDF 70
            :..|||.|.|:.|:|.:..||. .|..|   ::.:.|.:.::...|.|..:|..|.:.|.....|
  Fly     2 LQNVCRVCASSTDNSKSLKLFN-SGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISF 65

  Fly    71 QKQCVDSVQKFQDLVASNAFACQTNFDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEIIENEEDV 135
            :.:|:.|.:.|::                                           .::.||||.
  Fly    66 RDRCLRSQKIFEE-------------------------------------------SLVRNEEDT 87

  Fly   136 FKMLESVEKEVEEVEMEME--------QPFGRVSQDDSFESGNDNDLDADFQISSDD-DIPLAQR 191
            |:  .||.:.........|        .|...:.:.:|..:|::.|...|...|.:: |:.||.:
  Fly    88 FR--SSVRRSARSQRQRHEDTAPKTPASPLEVMIKLESLSNGDEEDDGIDHLDSCNEADMELAIK 150

  Fly   192 SRRGATRGSKAKGKPKSAAKRQEEESEESEETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCH 256
            :                              .|||.:.||.  ..|.|     .:|.|.|
  Fly   151 A------------------------------MSSSTEDDGT--TSPVR-----LKRTRRR----- 173

  Fly   257 ICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCN 321
                                          ..:||....|..:|.:
  Fly   174 ------------------------------GLKKGGKGENRTKVTL------------------- 189

  Fly   322 KSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFP 386
                 ||                  |.|.:|.......::..:|:.||:|.. ||.||:|..||.
  Fly   190 -----PV------------------FFCDQCGNNITGKSSFDRHLRKHSGIR-PFQCELCPARFL 230

  Fly   387 INSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHV 451
            .:..|:.|.:.|.|                            ::|::||.||....|......|.
  Fly   231 SSGELKGHQVMHTG----------------------------DRKFQCRYCDRTYVNYSGRLRHE 267

  Fly   452 KVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTH----- 511
            : .|...:.|.|..|||:|..|:..|.|...||||:...|::|.:.|    ....|||||
  Fly   268 R-THTNDRPFICAQCGKSFTNSYILKNHMLIHTGERLFRCELCHRSF----ARPTHLKTHFRSNT 327

  Fly   512 EKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQL-AGTVANPIPS 565
            .|.:|.|:      |.|......:.::.:..::...|:...|:. |.|:..|:|:
  Fly   328 HKHNLEKS------MADAGGVQLSPSQSADQVKFVTEKEPEAEADAFTIEVPLPA 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	21/73 (29%)
		C2H2 Zn finger	255..275	CDD:275368	0/19 (0%)
		C2H2 Zn finger	283..335	CDD:275368	6/51 (12%)
		C2H2 Zn finger	318..338	CDD:275368	2/19 (11%)
		COG5048	<347..512	CDD:227381	47/169 (28%)
		C2H2 Zn finger	349..369	CDD:275368	3/19 (16%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	0/19 (0%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..607	CDD:275368
		C2H2 Zn finger	615..635	CDD:275368
		zf-H2C2_2	627..652	CDD:290200
		C2H2 Zn finger	643..663	CDD:275368
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	21/73 (29%)
		C2H2 Zn finger	194..214	CDD:275368	3/19 (16%)
		COG5048	<197..322	CDD:227381	43/158 (27%)
		zf-H2C2_2	206..231	CDD:290200	11/25 (44%)
		C2H2 Zn finger	222..242	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/20 (30%)
		zf-H2C2_2	265..287	CDD:290200	8/22 (36%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		zf-H2C2_2	291..315	CDD:290200	9/27 (33%)
		C2H2 Zn finger	306..328	CDD:275368	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100