DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and CG11247

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	134/598 - (22%)
Similarity:	223/598 - (37%)	Gaps:	144/598 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 VSQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKSAAKRQ---EEESEESE 221
            ||::|:.....|:.:    .:||.   |.|:.|..|.|...|.: |...|:.|.   :||.::..
  Fly     8 VSKEDAVSLLTDSGI----SLSSP---PAARESSPGPTLAIKRR-KSSLASLRDACVDEEEDDGG 64

  Fly   222 ETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286
            |..|.||....|:.|...::....:|..|   .|..|.::|......:.||..|:|..|.:|  :
  Fly    65 EQDSKDDDYVQPQLKKSARKGEPVKRKHH---VCSQCSKEFGGKTDLQRHMLIHSDERPHKC--K 124

  Fly   287 SCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTE 351
            .|.|.:..|..|:.|:..||.                         |.|:          |.|::
  Fly   125 DCGKSYRQAVNLKNHITTAHE-------------------------HRKQ----------FVCSQ 154

  Fly   352 CEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRH--AGIKNHVCPYCGVGKT 414
            |.|.|.....|:.||..|:||: |:.|::|.|:|.....|:.|::.|  ..|:...|..|....:
  Fly   155 CPKSFALKERLRLHMRLHSGEK-PYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218

  Fly   415 TRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIH 479
            |......|:..|.:..::.|..|::...|:.||..|:...|.|...|.|:.|.|..........|
  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATH 283

  Fly   480 ERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSPHLR 544
            .:.||..|...|::|...|..:.....|::.|                   :|
  Fly   284 MQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMH-------------------TG------------ 317

  Fly   545 GRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQK 609
                                                |..:.|..|.:.|.|.|.:|||.: .|..
  Fly   318 ------------------------------------ERPYQCRICHQTFAHSSVLKLHIR-KHTG 345

  Fly   610 VKDFCCRFCPKR--FAKKQYLRHH-EYIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPG 671
            .|.|.|:.|...  |::..:|::| :.||..:|||.|:.|...|:.:..|::|::...|.|....
  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGD 410

  Fly   672 KPKEPAGPKAESSTAVKRQQPKNFEQYQDPAAERAAATAELLAYQIEENEAKRKAEAELRKIQEA 736
            |   |:|.::|.:      |..:..::......:..::|:.|          |:...|.|.|...
  Fly   411 K---PSGNQSEDA------QILSVLRFNMAVVLKKISSAQKL----------RQLGYEKRLIDNV 456

  Fly   737 AFEQLNKLQKQSN 749
            ....|...|:||:
  Fly   457 IIASLKLAQRQSH 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	9/51 (18%)
		C2H2 Zn finger	318..338	CDD:275368	2/19 (11%)
		COG5048	<347..512	CDD:227381	45/166 (27%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	4/19 (21%)
		C2H2 Zn finger	491..511	CDD:275368	4/19 (21%)
		C2H2 Zn finger	586..607	CDD:275368	8/20 (40%)
		C2H2 Zn finger	615..635	CDD:275368	5/22 (23%)
		zf-H2C2_2	627..652	CDD:290200	10/25 (40%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	47/199 (24%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	8/26 (31%)
		C2H2 Zn finger	123..144	CDD:275368	6/22 (27%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/24 (46%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	47/244 (19%)
		C2H2 Zn finger	210..230	CDD:275370	4/19 (21%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	4/19 (21%)
		zf-H2C2_2	309..332	CDD:290200	7/89 (8%)
		C2H2 Zn finger	323..343	CDD:275368	8/20 (40%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930