DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and Neu2

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	116/485 - (23%)
Similarity:	182/485 - (37%)	Gaps:	131/485 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SAAYDLFRVPGLAKKLCV--CTSLSVEQADGFPKNLCNVCFSKLNDLHDFQKQCVDSVQKFQDLV 85
            ::.:|....|||:....:  ||...||:.|.....:|              |.|::..|
  Fly     2 ASVFDESHEPGLSIAYIIYKCTGWQVEKHDPLSNTIC--------------KSCLEDAQ------ 46

  Fly    86 ASNAFACQTNFDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEIIENEEDVFKMLESVEKEVEEVE 150
              ||      ||:::|         .|..:..:..|.:.:.|..||:.      ....:|||..|
  Fly    47 --NA------FDIIET---------YERSHQFYRFLKDVREEESENDG------SGCSEEVEAAE 88

  Fly   151 MEMEQPFGRVSQD--DSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKSAAKRQ 213
            .::        ||  |..:|||:.|:       ::.||              |||.||..:...
  Fly    89 RDL--------QDGADDVDSGNEPDI-------NECDI--------------KAKEKPGFSCSH- 123

  Fly   214 EEESEESEETSSSDDSDGNPKDKPKRKRIPATERDR--HRLIDCHICHQKFKKAIRYEEHMKHHN 276
                              .||....:..:....|..  .|...|.:|.:.|..:...:.||:.|.
  Fly   124 ------------------CPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHT 170

  Fly   277 DLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVD 341
            ...||||:  .|.:.||..:.|:.|:: .|....::. |.|  |.|.|...::|..|:    ...
  Fly   171 GERPFQCS--HCPRSFTAGHHLKAHIQ-MHERRGSLR-CPY--CQKCFLTSLILKQHL----ATH 225

  Fly   342 TPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGI----- 401
            |.:..|.|::|.|.|:....|..||..|  :|..|.|..|.|.|.:::.|:.||.|:|..
  Fly   226 TDETQFKCSQCSKSFQVEHELWMHMRVH--QERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSK 288

  Fly   402 ----------KNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHE 456
                      |...|..|....|.|...:.|:.:|||.|......| .:|.:|.|.:|      .
  Fly   289 ASAHKTLGHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPC-KSSGSKPAHSN------A 346

  Fly   457 KRKDFACQYCGKTFGKSHACKIHERSHTGE 486
            :||.|.|..|.:||.:..|...|.::|||:
  Fly   347 QRKPFKCSSCPRTFSRKSALLTHLQTHTGK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	13/61 (21%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	14/51 (27%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		COG5048	<347..512	CDD:227381	47/155 (30%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	586..607	CDD:275368
		C2H2 Zn finger	615..635	CDD:275368
		zf-H2C2_2	627..652	CDD:290200
		C2H2 Zn finger	643..663	CDD:275368
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	19/97 (20%)
		COG5048	<119..241	CDD:227381	32/150 (21%)
		C2H2 Zn finger	121..141	CDD:275368	3/38 (8%)
		zf-H2C2_2	133..158	CDD:290200	5/24 (21%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		zf-H2C2_2	162..185	CDD:290200	8/24 (33%)
		C2H2 Zn finger	177..197	CDD:275368	6/22 (27%)
		C2H2 Zn finger	205..225	CDD:275368	7/25 (28%)
		zf-C2H2_8	206..286	CDD:292531	27/87 (31%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	9/36 (25%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930