DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and CG7386

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	346/776 - (44%)
Similarity:	457/776 - (58%)	Gaps:	143/776 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESQYSIHTVCRTCLSTVDDSAAYDLFRVPGLAKKLCVCTSLSVEQADGFPKNLCNVCFSKLNDLH 68
            |.:||:.::|.|||..:...|.:|||.||.|.:||..|||...:|.||||:|||..||:||||||
  Fly     2 ELKYSVQSLCLTCLVHLKHGAGHDLFVVPDLFQKLRACTSFDADQNDGFPRNLCTQCFTKLNDLH 66

  Fly    69 DFQKQCVDSVQKFQDLVASNAFACQTN--FDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEIIEN 131
            ||::.|.:|:::.::::.|     |.|  ..|.::.|..::.|...|:...||||||:|:|:|:|
  Fly    67 DFRELCAESIKRLKEMMTS-----QRNMPMGVFESIADDSEAPERPEEPASFDPLLNNKLEMIDN 126

  Fly   132 EEDVFKMLESVEKEVEEVEMEMEQPFGRVSQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGA 196
            ||||||:||.|:||:||        ..|...::.|.|...|.|
  Fly   127 EEDVFKLLEKVDKELEE--------HSRDQSEEHFSSAEHNGL---------------------- 161

  Fly   197 TRGSKAKGKPKSAAKRQEEESEESEETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQK 261
                             |||.:|||..:|.|:      ....::||...:|...||:.|.||.||
  Fly   162 -----------------EEEKKESEGFNSDDE------QAMGQRRIANDKRKLFRLMSCSICQQK 203

  Fly   262 FKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFAR 326
            |||..::|||||||||||||||..||||||||||..||:||::||::.....|||.|||...|:|
  Fly   204 FKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSR 268

  Fly   327 PVLLSFHMKRVH---KVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPIN 388
            ..||:.|:|:||   :|..|:.:..|.||..|||||.|:|||||.|||||||:.|.||||.|.||
  Fly   269 LRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYIN 333

  Fly   389 SVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKV 453
            |.|::||||||||||:||.||||.|||||||:||||.||:..:::||.||:|:|.|:.|.:|||:
  Fly   334 SALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKI 398

  Fly   454 VHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKR---- 514
            ||||.::||||||||||||::||||||.:|||||.||||:|.|.||..:.|..|||.|||.
  Fly   399 VHEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERA 463

  Fly   515 -----------DLPKTQ-GTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVN 567
                       |...|| .::.|:...|...::|.| :|.   |||:||:|.||||..||
  Fly   464 LETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPK-NPR---RVEQVDVALLAGTAVNP----- 519

  Fly   568 LPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHE 632
                :.::.|.:|||.::||.|.:||..:.|||.|||.||:|||||.||||.:|||..|.::.||
  Fly   520 ----TDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHE 580

  Fly   633 YIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPGKPKEPAGPKAESSTAVKRQQPKNFEQ 697
            :|||||||:|||.||..|||...|..|.||||:      ||.:|.|
  Fly   581 WIHTGEKPFECKTCGNRFRQVAALIRHQKVHDE------KPAKPLG------------------- 620

  Fly   698 YQDPAAERAAATAELLAYQIEENEAKRKAEAELRKIQEAAFEQLN------KLQKQSNTYD 752
                                |.|:.|:|.||..::|.:.|.::|.      .|:||.:||:
  Fly   621 --------------------ERNDRKQKVEALRQEIAKVAKKELKDLKNQLALEKQQDTYE 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	36/70 (51%)
		C2H2 Zn finger	255..275	CDD:275368	13/19 (68%)
		C2H2 Zn finger	283..335	CDD:275368	28/51 (55%)
		C2H2 Zn finger	318..338	CDD:275368	9/19 (47%)
		COG5048	<347..512	CDD:227381	110/164 (67%)
		C2H2 Zn finger	349..369	CDD:275368	14/19 (74%)
		C2H2 Zn finger	378..398	CDD:275368	13/19 (68%)
		C2H2 Zn finger	406..426	CDD:275368	16/19 (84%)
		C2H2 Zn finger	434..455	CDD:275368	11/20 (55%)
		C2H2 Zn finger	463..483	CDD:275368	16/19 (84%)
		C2H2 Zn finger	491..511	CDD:275368	10/19 (53%)
		C2H2 Zn finger	586..607	CDD:275368	11/20 (55%)
		C2H2 Zn finger	615..635	CDD:275368	10/19 (53%)
		zf-H2C2_2	627..652	CDD:290200	15/24 (63%)
		C2H2 Zn finger	643..663	CDD:275368	10/19 (53%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	36/70 (51%)
		C2H2 Zn finger	197..217	CDD:275368	13/19 (68%)
		C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	323..343	CDD:275368	13/19 (68%)
		C2H2 Zn finger	351..371	CDD:275368	16/19 (84%)
		C2H2 Zn finger	379..400	CDD:275368	11/20 (55%)
		C2H2 Zn finger	408..428	CDD:275368	16/19 (84%)
		C2H2 Zn finger	436..456	CDD:275368	10/19 (53%)
		C2H2 Zn finger	534..555	CDD:275368	11/20 (55%)
		C2H2 Zn finger	563..583	CDD:275368	10/19 (53%)
		zf-H2C2_2	575..600	CDD:290200	15/24 (63%)
		C2H2 Zn finger	591..611	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77239
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990