DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and D19A

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	851	Identity:	564/851 - (66%)
Similarity:	642/851 - (75%)	Gaps:	83/851 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNEESQYSIHTVCRTCLSTVDDSAAYDLFRVPGLAKKLCVCTSLSVEQADGFPKNLCNVCFSKLN 65
            |||..|||||::||.||:.:.:.|||||:.||||:||||.||||||||.||||||||.:|::|||
  Fly     1 MNEGRQYSIHSLCRICLNHLQNDAAYDLYLVPGLSKKLCFCTSLSVEQNDGFPKNLCTLCYTKLN 65

  Fly    66 DLHDFQKQCVDSVQKFQDLVASNAFACQTNFDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEIIE 130
            :||||||||||||||||||||||.||||::|||.|.:.||.|.|.||||:|::|||||.|:|:||
  Fly    66 ELHDFQKQCVDSVQKFQDLVASNVFACQSSFDVFDPNVAVQDYPAEEEDHVNYDPLLNHKMELIE 130

  Fly   131 NEEDVFKMLESVEKEVEEVEMEM---EQPFGRVS-----QDDSFESGNDNDLDADFQ-ISSDDDI 186
            ||||||||||.|:||.||||.|.   |...|.||     .|.|.|||||||.|.||: .||||||
  Fly   131 NEEDVFKMLEHVDKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDI 195

  Fly   187 PLAQRSRRGATRGS---------------KAKGKPKSAAKRQEEESEESEETSSSDDS-DGNPK- 234
            |||||.|..|| ||               :.:|:||.......||.|.|:.:|.|||| ||..:
  Fly   196 PLAQRMRGPAT-GSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGTSRG 259

  Fly   235 DKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLR 299
            |||||||||..||..||:|||||||||||||||||||||:|||||||||.||:|:||||||||||
  Fly   260 DKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLR 324

  Fly   300 VHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVH---KVDTPQRDFPCTECEKVFRCPTA 361
            :|::|||||.|.:|.|..|||.|:|.|..||:||||:||   |...|.||||||||:.|||||||
  Fly   325 IHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRCPTA 389

  Fly   362 LKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTH 426
            ||||||||||||||:.|.||||||.|||.|||||:||||||||||||||||||||||||.|||||
  Fly   390 LKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTH 454

  Fly   427 TKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCEC 491
            |||||::||||||||||||||:|||||||||||||||||||||||||||||:|||||||||||||
  Fly   455 TKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSHTGEKCCEC 519

  Fly   492 KICGKVFLFEKGLTKHLKTHEKRDLPKT---------------------QGTNALMGDG------ 529
            |||||:||.||.||||||||||||||..                     |....:..||
  Fly   520 KICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQMQTDGLVPMDP 584

  Fly   530 ----------ASGSSTIA-KPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQ 583
                      |.|..|.| .|.|....||:||||:|||||..||||||::|||||||||||||||
  Fly   585 NQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQ 649

  Fly   584 HICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGK 648
            ||||.||:|||::.|||||||::|:|||||.||||||||:|.|.|||||:|||||||:|||:|||
  Fly   650 HICPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGK 714

  Fly   649 HFRQEQVLKTHMKVHDKPPR----PPGKPKEPAGPKAESSTAVKRQQPKNFEQYQDPAAERAAAT 709
            |||||..||.|:|.|:||.|    ....|.:....|.|...     :|:||:||||||.||||||
  Fly   715 HFRQETALKKHIKTHEKPNRRHVPERSAPTQITFRKLEPDA-----EPRNFDQYQDPAVERAAAT 774

  Fly   710 AELLAYQIEENEAKRKAEAELRKIQEAAFEQLNKLQKQ------SNTYDGFYAQKAEAEGTSVDA 768
            |||||:|:||||||||||.|.:||..||.|||.|||:|      :.:|||:|||||::||||:||
  Fly   775 AELLAHQLEENEAKRKAEIERQKIAAAACEQLTKLQQQQEIIKATTSYDGYYAQKAQSEGTSLDA 839

  Fly   769 LKLDHV 774
            ||:|||
  Fly   840 LKIDHV 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	52/70 (74%)
		C2H2 Zn finger	255..275	CDD:275368	19/19 (100%)
		C2H2 Zn finger	283..335	CDD:275368	33/51 (65%)
		C2H2 Zn finger	318..338	CDD:275368	12/19 (63%)
		COG5048	<347..512	CDD:227381	148/164 (90%)
		C2H2 Zn finger	349..369	CDD:275368	17/19 (89%)
		C2H2 Zn finger	378..398	CDD:275368	15/19 (79%)
		C2H2 Zn finger	406..426	CDD:275368	18/19 (95%)
		C2H2 Zn finger	434..455	CDD:275368	19/20 (95%)
		C2H2 Zn finger	463..483	CDD:275368	18/19 (95%)
		C2H2 Zn finger	491..511	CDD:275368	16/19 (84%)
		C2H2 Zn finger	586..607	CDD:275368	14/20 (70%)
		C2H2 Zn finger	615..635	CDD:275368	15/19 (79%)
		zf-H2C2_2	627..652	CDD:290200	20/24 (83%)
		C2H2 Zn finger	643..663	CDD:275368	14/19 (74%)
D19A	NP_477304.1	zf-AD	12..83	CDD:214871	52/70 (74%)
		C2H2 Zn finger	343..362	CDD:275368	12/18 (67%)
		C2H2 Zn finger	377..397	CDD:275368	17/19 (89%)
		zf-H2C2_2	389..414	CDD:290200	21/24 (88%)
		C2H2 Zn finger	406..426	CDD:275368	15/19 (79%)
		C2H2 Zn finger	434..454	CDD:275368	18/19 (95%)
		C2H2 Zn finger	462..483	CDD:275368	19/20 (95%)
		C2H2 Zn finger	491..511	CDD:275368	18/19 (95%)
		C2H2 Zn finger	519..539	CDD:275368	16/19 (84%)
		C2H2 Zn finger	652..673	CDD:275368	14/20 (70%)
		C2H2 Zn finger	681..701	CDD:275368	15/19 (79%)
		zf-H2C2_2	694..718	CDD:290200	20/23 (87%)
		C2H2 Zn finger	709..729	CDD:275368	14/19 (74%)
		tolA_full	724..>814	CDD:274303	52/94 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449734
Domainoid	1	1.000	59	1.000	Domainoid score	I17733
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77239
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.990