DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and CG10274

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	502/872 - (57%)
Similarity:	609/872 - (69%)	Gaps:	114/872 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EESQYSIHTVCRTCLSTVDD----SAAYDLFRVPGLAKKLCVCTSLSVEQADGFPKNLCNVCFSK 63
            |.:|||:|.|||.||:.:.:    :.::|||.:|||||||||||||:|||:|||||.||..|||:
  Fly     6 EAAQYSVHAVCRICLNRLPENGGGAGSFDLFLIPGLAKKLCVCTSLAVEQSDGFPKCLCAQCFSR 70

  Fly    64 LNDLHDFQKQCVDSVQKFQDLVASNAF-----ACQTNFDVLDTSAAVADLPG-EEEDNVHFDPLL 122
            |:|:|:|||.||||||||||:||.|.|     |...|||:|:.:....:|.| :|||.::|||||
  Fly    71 LDDMHEFQKLCVDSVQKFQDMVARNVFCPPASAQMKNFDLLNVAGNEPELVGQDEEDRINFDPLL 135

  Fly   123 NSKIEIIENEEDVFKMLESVEKEVEEVEMEMEQP----------FGRVSQDDSFESGNDNDLDAD 177
            :.|:|:||||||||||||.|:||.|:||.|::|.          |...|.::|.|   |.|.|.|
  Fly   136 DHKMEMIENEEDVFKMLEHVDKEAEQVEKEVKQDELDAADLMTIFAAESSEESEE---DIDQDVD 197

  Fly   178 FQISS---DDDIPLAQRSRRGATRGSKAKGKPKSAAKRQEEESEESEETSSSDDSDGNPKDKPKR 239
            |:.:|   |||:|||||.|      ..::..||:.|...:||.:|....|..:|.||. |.|.:|
  Fly   198 FEPNSSDGDDDVPLAQRLR------DNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGE-KSKSRR 255

  Fly   240 KRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEH 304
            ||||..||..||:|||||||||||||||||||||||||||||||.||:||||||||.|||:|::|
  Fly   256 KRIPPGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDH 320

  Fly   305 AHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVH---KVDTPQRDFPCTECEKVFRCPTALKKHM 366
            ||||.|.:|.|..:||.|:|.|..||:||||::|   |...|.||:||||||||||||.||||||
  Fly   321 AHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHM 385

  Fly   367 YKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKK 431
            |||.|:||||.|.||||||.|||.|:|||:|||||||:||||||||||||||||.||||||:|||
  Fly   386 YKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKK 450

  Fly   432 YECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGK 496
            ::|..|:|||||||:||||:|:||||.|::|||||||||||||||||||.:|||||.||||:|||
  Fly   451 FKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGK 515

  Fly   497 VFLFEKGLTKHLKTHEKRDL--------------------------PKTQG-----------TNA 524
            .||:.|.|||||||||||.|                          |..:|           .:.
  Fly   516 KFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADE 580

  Fly   525 LMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDC 589
            |:...|...:||.| .|.   ||:|||:||||||..||||||::||||||||||||||:||||.|
  Fly   581 LLKVCAESVATIPK-DPR---RVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGC 641

  Fly   590 GKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQ 654
            |:|||::.|||.|||::|:|||||.||||||||||.|.|||||:|||||||:|||.||.|||||.
  Fly   642 GQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQET 706

  Fly   655 VLKTHMKVHD-KPP-----------------RPPGKPKEPAGPK-AESSTAVKRQQPK------- 693
            .||.|.:.|: :||                 |...:.|..|..| .|.:.|.|.|...
  Fly   707 ALKRHQRTHENRPPVISPKFYAAREELEEQERSKREAKRQADAKRREIAEAAKEQLSSLHKLESS 771

  Fly   694 -----NFEQYQDPAAERAAATAELLAYQIEENEAKRKAEAELRKIQEAAFEQLNKLQ------KQ 747
                 ::::||:.|||||||:|||.|.|.||||.||.||.|.||:||||:|||..||      |.
  Fly   772 DRSLHSYDEYQEAAAERAAASAELQAQQFEENEVKRLAEEERRKVQEAAYEQLQLLQHQQEVDKA 836

  Fly   748 SNTYDGFYAQKAEAEGTSVDALKLDHV 774
            .::|||:|||||.|:||::||||:|||
  Fly   837 QSSYDGYYAQKAHADGTTLDALKIDHV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	48/74 (65%)
		C2H2 Zn finger	255..275	CDD:275368	19/19 (100%)
		C2H2 Zn finger	283..335	CDD:275368	32/51 (63%)
		C2H2 Zn finger	318..338	CDD:275368	11/19 (58%)
		COG5048	<347..512	CDD:227381	132/164 (80%)
		C2H2 Zn finger	349..369	CDD:275368	18/19 (95%)
		C2H2 Zn finger	378..398	CDD:275368	14/19 (74%)
		C2H2 Zn finger	406..426	CDD:275368	18/19 (95%)
		C2H2 Zn finger	434..455	CDD:275368	14/20 (70%)
		C2H2 Zn finger	463..483	CDD:275368	18/19 (95%)
		C2H2 Zn finger	491..511	CDD:275368	14/19 (74%)
		C2H2 Zn finger	586..607	CDD:275368	13/20 (65%)
		C2H2 Zn finger	615..635	CDD:275368	16/19 (84%)
		zf-H2C2_2	627..652	CDD:290200	19/24 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	48/74 (65%)
		C2H2 Zn finger	334..353	CDD:275368	11/18 (61%)
		C2H2 Zn finger	368..388	CDD:275368	18/19 (95%)
		COG5048	394..729	CDD:227381	212/338 (63%)
		C2H2 Zn finger	397..417	CDD:275368	14/19 (74%)
		C2H2 Zn finger	425..445	CDD:275368	18/19 (95%)
		C2H2 Zn finger	453..474	CDD:275368	14/20 (70%)
		C2H2 Zn finger	482..502	CDD:275368	18/19 (95%)
		C2H2 Zn finger	510..530	CDD:275368	14/19 (74%)
		C2H2 Zn finger	638..659	CDD:275368	13/20 (65%)
		C2H2 Zn finger	667..687	CDD:275368	16/19 (84%)
		zf-H2C2_2	680..704	CDD:290200	19/23 (83%)
		C2H2 Zn finger	695..715	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449738
Domainoid	1	1.000	44	1.000	Domainoid score	I12262
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77239
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.990