DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and Oaz

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	153/744 - (20%)
Similarity:	228/744 - (30%)	Gaps:	259/744 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 QTNFDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEIIE---------------NEEDVFKMLESV 142
            |.::...|..||.|.:..|||.....:.|.:.:.|::.               :|||      :|
  Fly    75 QQSWPTADEPAAPAAVAKEEEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEED------AV 133

  Fly   143 EKEVEEVEMEMEQPFGRVSQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPK 207
            :.| |..::|::.....:|.|:.::......||:.:     .|:.....|...:...|.....|.
  Fly   134 DAE-EPEDLELDDELLSLSGDEDYDDEELQSLDSFY-----SDMYSTHTSSSYSPSISDGTMTPN 192

  Fly   208 S-------AAKRQEEESEESEETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKA 265
            |       .|..||:...|.:....:|.     :|.||.||:|......|.    |..||   :|
  Fly   193 SHHLIGAPTAAGQEDHPTEGKINGGADG-----EDLPKPKRLPHFHHHHHH----HYHHQ---QA 245

  Fly   266 IRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLL 330
            ::....::..|         :..:.|.|...|       |....|.....|.||..
  Fly   246 LKIANKLRKIN---------KEAKMGATAGGG-------ATGAASKFDKLTGEGIK--------- 285

  Fly   331 SFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHL 395
                      ......:.|..|||.|.....||.|:..| .|.|||.||.|.|.|........|.
  Fly   286 ----------SRGDGSYQCQFCEKTFPRLGYLKHHVQSH-AEHLPFKCEYCSKLFKHKRSRDRHK 339

  Fly   396 LRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEK--- 457
            ..|...:|:.||:|....:.......|:.||..:|.::|..|:...:...||.:|:: .|:|
  Fly   340 KLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQ-KHKKNAA 403

  Fly   458 -----------------------------------------------RKDF-------------- 461
                                                           |.||
  Fly   404 ILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTT 468

  Fly   462 --------ACQYCGKT--FG-----KSHACKIHERSHT---------GEKC-CECKICGKVFLFE 501
                    .|.||.|.  |.     .:|...:||:..|         ||.. ..|:.|...|...
  Fly   469 TATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNI 533

  Fly   502 KGLTKHLK-THEKR--------------------------DLPKTQGTNALMGDGASGSSTIAKP 539
            .||.:|:: ||..|                          ||||                  .||
  Fly   534 AGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPK------------------IKP 580

  Fly   540 ---SPHLRGRVERVDI-AQLAGTVANPI------------PS------------VNLPSWSPQVN 576
               ||....|....|: ..|:.....|:            ||            ..||.:....|
  Fly   581 DLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRN 645

  Fly   577 FTKK---EG-QHICPDCGKGFNHVSNMKLHYKVVHQKV--KDF-CCRFCPKRFAKKQYLRHH--- 631
            ..|.   || |.:||.||......|..:.|. |.|..:  .:| |...|.|.|||.:.|:.|
  Fly   646 HLKSHIAEGMQLVCPHCGMSLPEQSEFERHV-VGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLS 709

  Fly   632 EYIHTGEKPYECKVCGKHFRQEQVLKTHM 660
            |::.|..|   |.:|.:.......::.|:
  Fly   710 EHVLTLLK---CSLCSELCESRMAMQLHL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	8/51 (16%)
		C2H2 Zn finger	318..338	CDD:275368	2/19 (11%)
		COG5048	<347..512	CDD:227381	56/254 (22%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	8/26 (31%)
		C2H2 Zn finger	491..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	586..607	CDD:275368	7/20 (35%)
		C2H2 Zn finger	615..635	CDD:275368	8/22 (36%)
		zf-H2C2_2	627..652	CDD:290200	7/27 (26%)
		C2H2 Zn finger	643..663	CDD:275368	3/18 (17%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-H2C2_2	334..359	CDD:290200	6/24 (25%)
		COG5048	336..769	CDD:227381	84/423 (20%)
		zf-C2H2	348..370	CDD:278523	4/21 (19%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		C2H2 Zn finger	378..398	CDD:275368	5/20 (25%)
		C2H2 Zn finger	630..650	CDD:275368	4/19 (21%)
		C2H2 Zn finger	659..679	CDD:275368	7/20 (35%)
		C2H2 Zn finger	689..707	CDD:275368	7/17 (41%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930