DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and crol

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	631	Identity:	168/631 - (26%)
Similarity:	235/631 - (37%)	Gaps:	168/631 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 LIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCT 316
            :..|.:|...|......|.|||.|:...||.||:  |:|.|.....|..|. .:||..:... |.
  Fly   276 MFTCIVCFNVFANNTSLERHMKRHSTDKPFACTI--CQKTFARKEHLDNHF-RSHTGETPFR-CQ 336

  Fly   317 YEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVF-------------------RCPTAL 362
            |  |.|:|.|...:..|::: |..:||.|   |..|:|.|                   :|....
  Fly   337 Y--CAKTFTRKEHMVNHVRK-HTGETPHR---CDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCG 395

  Fly   363 KK---------HMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQE 418
            ||         ||..|| .|.||.||||||.|.......:|:|.|.|...|.|.:|....|.::.
  Fly   396 KKYTRKEHLANHMRSHT-NETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEH 459

  Fly   419 WNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSH 483
            ...|:..||.|..:.|..|......|:.|.||:: .|.....|.|.||.|.|.:......|.|.|
  Fly   460 LLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIR-QHTGETPFKCTYCTKAFTRKDHMVNHVRQH 523

  Fly   484 TGEKCCECKICGKVFLFEKGLTKHLKTH-----------EKRDLPKTQGTNAL---MGDGASGSS 534
            |||...:|..|.|.|..::.||.|::.|           :|....|...||.:   .||
  Fly   524 TGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGD------ 582

  Fly   535 TIAKPSPH-------LRGRVERVDIAQLAGTVANP--IPSVNLPSWSPQVNFTKKEGQHI----- 585
                 |||       ...|.|.::......:..||  ....|.|       ||:||  |:
  Fly   583 -----SPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKP-------FTRKE--HLINHMS 633

  Fly   586 ----------CPDCGKGFNHVSNMKLHYKVVHQKVKD----FCCRFCPKRFAKKQYLRHHEYIHT 636
                      |..|||.|....|:..|.: .|.|.::    |.|..|||.|..|.:|..|...|:
  Fly   634 RCHTGDRPFTCETCGKSFPLKGNLLFHQR-SHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHS 697

  Fly   637 GEKPYECKVCGKHFRQEQVLKTHMKVHDKP---PRPP--GKPKEPAG--------------PKAE 682
            ||||:.|.:|.|.|.:...||.|||::...   |.||  ..|:.|||              |...
  Fly   698 GEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHS 762

  Fly   683 SST-------------------------------------AVKRQQPKNFEQYQDPAAERAAATA 710
            ::|                                     |..:||.:..:.....||::.||.|
  Fly   763 ATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAA 827

  Fly   711 ELLAYQIEENEAKRKAEAELRKI-----QEAAF----EQLNKLQKQ 747
            .....|..:.:|....:...:::     |:||.    :|..:||:|
  Fly   828 AAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQ 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..335	CDD:275368	16/51 (31%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		COG5048	<347..512	CDD:227381	60/203 (30%)
		C2H2 Zn finger	349..369	CDD:275368	9/47 (19%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	7/20 (35%)
		C2H2 Zn finger	615..635	CDD:275368	8/19 (42%)
		zf-H2C2_2	627..652	CDD:290200	11/24 (46%)
		C2H2 Zn finger	643..663	CDD:275368	9/19 (47%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		COG5048	300..723	CDD:227381	133/455 (29%)
		C2H2 Zn finger	307..327	CDD:275368	7/22 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/22 (32%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	6/20 (30%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	4/19 (21%)
		C2H2 Zn finger	587..607	CDD:275368	2/19 (11%)
		C2H2 Zn finger	615..636	CDD:275368	7/29 (24%)
		C2H2 Zn finger	644..664	CDD:275368	7/20 (35%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840