DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and CG2120

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	319	Identity:	84/319 - (26%)
Similarity:	123/319 - (38%)	Gaps:	84/319 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 TECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKT 414
            |:..|..|.||. |:|  :.||::  ..|:||.:||.....||.|.:.|...|.|||..||.|..
  Fly    78 TDMCKPKRTPTT-KRH--RTTGKD--HTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFR 137

  Fly   415 TRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIH 479
            ...:...|.:|||.|:.::                             |..|||.|..::...:|
  Fly   138 QLNKLRIHAVTHTAERPHK-----------------------------CDICGKGFRYANYLTVH 173

  Fly   480 ERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSP-HL 543
            .|.|||||...|      ...:..|:.| ..|.:|...|.:  :|...|          |.| |.
  Fly   174 RRLHTGEKPYPC------LATDCHLSFH-SIHARRIHTKLR--HAAQTD----------PDPEHP 219

  Fly   544 RGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQ 608
            ....|:.|.:.|:.|                           ||.|.:.......:.:|.| .|.
  Fly   220 LAEQEQRDTSALSFT---------------------------CPVCSRVLTDQCYLSIHLK-RHY 256

  Fly   609 KVKDFCC--RFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDK 665
            ..:||.|  ..|.|||.....|:||:..||.::|:.|.:|...|.::...|.|:|||::
  Fly   257 NQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..335	CDD:275368
		C2H2 Zn finger	318..338	CDD:275368
		COG5048	<347..512	CDD:227381	45/161 (28%)
		C2H2 Zn finger	349..369	CDD:275368	7/18 (39%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..455	CDD:275368	0/20 (0%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	3/19 (16%)
		C2H2 Zn finger	586..607	CDD:275368	5/20 (25%)
		C2H2 Zn finger	615..635	CDD:275368	8/21 (38%)
		zf-H2C2_2	627..652	CDD:290200	9/24 (38%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	113..138	CDD:290200	11/24 (46%)
		C2H2 Zn finger	129..149	CDD:275368	5/19 (26%)
		zf-H2C2_2	142..166	CDD:290200	10/52 (19%)
		COG5048	151..>264	CDD:227381	36/188 (19%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	5/27 (19%)
		C2H2 Zn finger	235..255	CDD:275368	5/20 (25%)
		C2H2 Zn finger	263..285	CDD:275368	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930