DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and Plag1

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001008317.1	Gene:	Plag1 / 297804	RGDID:	1305286	Length:	499	Species:	Rattus norvegicus

Alignment Length:	267	Identity:	78/267 - (29%)
Similarity:	115/267 - (43%)	Gaps:	37/267 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 ETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286
            :.|...|:...|..|.||     .|....:...|.:|.:.|....:.:.|...|....|::||.:
  Rat     8 DLSEVRDTQKAPSGKRKR-----GESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQ 67

  Fly   287 SCRKGFTTANGLRVHV-EHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCT 350
            .|.|.|.:...|:.|: .|:..:|   |.|.|  |.|.|.|...|..|:   |..|..:..|.|.
  Rat    68 DCTKAFVSKYKLQRHMATHSPEKT---HKCNY--CEKMFHRKDHLKNHL---HTHDPNKETFKCE 124

  Fly   351 ECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTT 415
            ||.|.:......|:|:..|........|::|.:.|....||.:||..|||..:.     ||
  Rat   125 ECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSG-----GV---- 180

  Fly   416 RQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFG-KSHACKIH 479
                        ||||::|..|:...:.::.:..|: |||..||||.||||.:.|| |.|..:..
  Rat   181 ------------KEKKHQCEHCERRFYTRKDVRRHM-VVHTGRKDFLCQYCAQRFGRKDHLTRHM 232

  Fly   480 ERSHTGE 486
            ::||..|
  Rat   233 KKSHNQE 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	18/52 (35%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		COG5048	<347..512	CDD:227381	45/141 (32%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..455	CDD:275368	4/20 (20%)
		C2H2 Zn finger	463..483	CDD:275368	8/20 (40%)
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	586..607	CDD:275368
		C2H2 Zn finger	615..635	CDD:275368
		zf-H2C2_2	627..652	CDD:290200
		C2H2 Zn finger	643..663	CDD:275368
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		7/29 (24%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		20/80 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	4/19 (21%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		69/229 (30%)
		SFP1	<58..139	CDD:227516	27/88 (31%)
		C2H2 Zn finger	64..86	CDD:275368	7/21 (33%)
		zf-H2C2_2	79..103	CDD:404364	10/28 (36%)
		C2H2 Zn finger	94..114	CDD:275368	9/24 (38%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		C2H2 Zn finger	187..207	CDD:275368	4/20 (20%)
		C2H2 Zn finger	215..233	CDD:275368	8/17 (47%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..400
		Massively activates transcription. /evidence=ECO:0000250	384..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100