DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and znf-782

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	133/560 - (23%)
Similarity:	211/560 - (37%)	Gaps:	148/560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 DNVHF-DPLLNSKIEIIENEEDVFKMLESVEKEVEEVEMEMEQPFGRVSQDDSFESGNDNDLDAD 177
            |::|. ||           ||:.|   |..|.|:.|.|.|.::....:...||          |.
Worm    17 DDIHMKDP-----------EEEEF---EEYEDELLEEEEEFDEELEELENSDS----------AS 57

  Fly   178 FQISSDDDIPLAQRSRRGATRGSKAKGKPKSAAKRQEEESEESEETSSSDDSDGNPKDKPKRKRI 242
            ..:|:            |:..||.:......::...:.:|     .|....|.|:|..:|:::.|
Worm    58 SLVSA------------GSPHGSSSSNGSHGSSPPLQVQS-----PSQGSGSSGSPTGQPEKRHI 105

  Fly   243 PATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHT 307
                        |.:|.:.|......|.|.:.|....|:.|  ..|:|.|.....|:|| |..||
Worm   106 ------------CTVCGKGFSYFSILESHKRSHTGEKPYNC--HFCQKTFAQKATLQVH-ERTHT 155

  Fly   308 ETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGE 372
             ....:.|.|  |.|:||:....:.|.|..|   ...|::.|.:|:|:...|:||..|  |.|..
Worm   156 -GERPYKCRY--CEKTFAQYGTKTVHEKSAH---LGIRNYKCPKCDKLLSSPSALYTH--KKTHG 212

  Fly   373 ELPFACEICGKRFPINSVLRDHL--LRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECR 435
            :..|.|:.|.|.|.:.:.|:.|:  :.....:.|||.||..|.........|:.|||.|:.|
Worm   213 DKTFRCDFCPKTFALKNYLKLHVKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGERPY--- 274

  Fly   436 QCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLF 500
                                      .|::|.|.|......:.|||:||||:...|:.|.:.|:.
Worm   275 --------------------------VCKFCPKAFASQGNLQSHERTHTGERPYSCQFCQRTFIQ 313

  Fly   501 EKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPS 565
            :..||.|..||    |.:....|.        .||.|             ||..:||:|.:
Worm   314 KSQLTAHESTH----LTQKHSVNP--------DSTTA-------------DILPVAGSVTD---- 349

  Fly   566 VNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRH 630
                        .:..|.:.|..|.|.:.:.|::.:|.: .|.:...:.|..|.|.:::|..|..
Worm   350 ------------HQMVGNYECTFCNKKYPYASSLYIHMR-KHTEKSAYSCDGCGKPYSQKISLNI 401

  Fly   631 HE--------YIHTGEKPY--ECKVCGKHFRQEQVLKTHM 660
            |:        .:.|.:..:  .|..|||.|.|...|:.|:
Worm   402 HQDQCEAFKNRLKTTDSQFSHNCDGCGKSFVQRIALQIHV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	17/51 (33%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		COG5048	<347..512	CDD:227381	46/166 (28%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..455	CDD:275368	0/20 (0%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..607	CDD:275368	5/20 (25%)
		C2H2 Zn finger	615..635	CDD:275368	6/27 (22%)
		zf-H2C2_2	627..652	CDD:290200	8/34 (24%)
		C2H2 Zn finger	643..663	CDD:275368	8/18 (44%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	5/19 (26%)
		zf-H2C2_2	119..143	CDD:290200	8/25 (32%)
		C2H2 Zn finger	134..154	CDD:275368	8/22 (36%)
		zf-H2C2_2	147..171	CDD:290200	11/27 (41%)
		C2H2 Zn finger	162..180	CDD:275368	7/19 (37%)
		COG5048	<187..404	CDD:227381	71/289 (25%)
		C2H2 Zn finger	191..211	CDD:275370	8/21 (38%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..285	CDD:290200	10/53 (19%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	10/24 (42%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..403	CDD:275368	5/16 (31%)
		C2H2 Zn finger	424..441	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910