DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and sem-4

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_491997.1	Gene:	sem-4 / 172435	WormBaseID:	WBGene00004773	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	141/743 - (18%)
Similarity:	232/743 - (31%)	Gaps:	245/743 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCVCTSL----------SVEQADGFPKNLCNVCFSK-------LNDLHDFQKQ------CVDSVQ 79
            |.:|..|          :.......|...|:..||.       :.|.|:.:::      |..:..
Worm    77 LSLCAQLGNSSSRNVSSTASTTSSCPIQSCSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFS 141

  Fly    80 KFQDLVASNAFACQTNFDVLDTSAAVADLPGEEEDNVHF-----DPLL----NSKIEIIE-NEED 134
            ..||:   ....||.......||...:.:|    .:|.|     .|.|    |..|...| .|||
Worm   142 NGQDI---REHKCQKTLASRSTSVPPSTIP----SSVCFLSTPTTPCLQFSINESIGTSEIREED 199

  Fly   135 VFKMLESVEKEVEEVEMEMEQPFGRVSQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRG 199
                 |..:.:||:.|....|.||.:.|                  .|||...:|..........
Worm   200 -----EEEDMDVEDGEHVANQLFGHLLQ------------------KSDDKSKMASLFNHAFPPF 241

  Fly   200 SKAKGKPKSAAKRQ----------------EEESEESEETSSSDDSD------GNPKDKPKRKRI 242
            :.....|.....||                :::.|...|.|:||:::      |:       |.:
Worm   242 AAFPNMPPPFLMRQPFDPRADVFAAGRHDNDDDWEALMEISTSDEAEKIRALVGD-------KAV 299

  Fly   243 PATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHT 307
            |.|:.::     |.:|.:........:.|.:.|....||:|.:  |::.|||...|:.|:....:
Worm   300 PTTDPNQ-----CILCRRVLSCKSALQMHYRTHTGERPFKCKI--CQRAFTTKGNLKTHMGVHRS 357

  Fly   308 ETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGE 372
            :.|      :.|...|.. |.|.:.|..: |::..|||       ..:...||:...........
Worm   358 KHS------FRGLPISLP-PQLAAMHQHQ-HQIAPPQR-------IHIHNPPTSAASAAAAVAQI 407

  Fly   373 ELPFACEICGKRFPINSVLRDHLLRH--------------------------------------- 398
            :....|.||.:||.....|..|:..|
Worm   408 QASQQCPICQQRFLNAGELAVHITEHRNSLTQPPRVMPTPTTTRVQTFPFVPFFTTPPSLNATDM 472

  Fly   399 -----------AGIKNHVCPYCGVG----KTTRQEWNK-----------------HILTHTKEKK 431
                       |.:||...|.....    |.||.:..|                 ..:..:.|.:
Worm   473 STQFNLANILSAQLKNDSSPNTDTSSVEEKITRDDPPKMASLSPSNSSDSSSSVRQDILESSEFE 537

  Fly   432 YECRQCDHASHNKQALANHVKVVHEK-----RKDFA-----------------CQYCGKTFGKSH 474
            .:.::.:.....:|.::......:|.     :|.:|                 |..|.|.|..|.
Worm   538 EKLKKLEEPPILEQQVSTTPNPKNENPLLAMQKMWAETEPPPPRQMPVLSKHQCGVCFKHFSSSS 602

  Fly   475 ACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKP 539
            |.:||.|:|||:|..:|.:||:.|.....|..|:.||..:..|..:|....  |.|  ||...||
Worm   603 ALQIHMRTHTGDKPFKCDMCGRAFTTRGNLKVHMGTHSWQQSPSRRGRRIF--DVA--SSVTEKP 663

  Fly   540 SPHLRGRVERVDIAQLAGTVANPI-PSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHY 603
                              .:.:|| |:...|..||....              |.|.:|.::: .
Worm   664 ------------------MLQSPILPTSGAPGASPLAML--------------GPNGLSGLEM-M 695

  Fly   604 KVVHQKVKDFCCRFCPKRFAKKQYLRHH 631
            .::.:.|...|.:.|......:|:|:.|
Worm   696 MMLWRTVCSVCQKVCQSPNELEQHLKEH 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	10/67 (15%)
		C2H2 Zn finger	255..275	CDD:275368	3/19 (16%)
		C2H2 Zn finger	283..335	CDD:275368	13/51 (25%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		COG5048	<347..512	CDD:227381	43/257 (17%)
		C2H2 Zn finger	349..369	CDD:275368	2/19 (11%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	5/40 (13%)
		C2H2 Zn finger	434..455	CDD:275368	1/20 (5%)
		C2H2 Zn finger	463..483	CDD:275368	9/19 (47%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..607	CDD:275368	3/20 (15%)
		C2H2 Zn finger	615..635	CDD:275368	4/17 (24%)
		zf-H2C2_2	627..652	CDD:290200	2/5 (40%)
		C2H2 Zn finger	643..663	CDD:275368
sem-4	NP_491997.1	C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		zf-H2C2_2	319..344	CDD:290200	7/26 (27%)
		C2H2 Zn finger	335..355	CDD:275368	7/21 (33%)
		lambda-1	553..>610	CDD:212564	11/56 (20%)
		zf-C2H2	589..611	CDD:278523	9/21 (43%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		zf-H2C2_2	603..628	CDD:290200	12/24 (50%)
		C2H2 Zn finger	619..639	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050