DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and plag1

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002934153.1	Gene:	plag1 / 100488503	XenbaseID:	XB-GENE-868443	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	118/519 - (22%)
Similarity:	182/519 - (35%)	Gaps:	122/519 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 ETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286
            :.|...|:...|..|.||     .|....:...|.:|.:.|....:.:.|...|....|::||.:
Frog     8 DLSEIRDTQTVPSGKRKR-----GETKPRKNFPCQLCEKAFNSVEKLKVHSYTHTGERPYKCTQQ 67

  Fly   287 SCRKGFTTANGLRVHV-EHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCT 350
            .|.|.|.:...|..|: .|:..:|   |.|.|  |.|.|.|...|..|:   |..|..:..|.|.
Frog    68 DCTKAFVSKYKLLRHMATHSPEKT---HKCNY--CEKMFHRKDHLKNHL---HTHDPNKEAFKCE 124

  Fly   351 ECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTT 415
            ||.|.:......|:|:..|........|::|.:.|....||.:||..|||..:     .||
Frog   125 ECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTVVLLEHLKTHAGKSS-----SGV---- 180

  Fly   416 RQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFG-KSHACKIH 479
                        ||||::|..||...:.::.:..|: |||..||||.||||.:.|| |.|..:..
Frog   181 ------------KEKKHQCEHCDRRFYTRKDVRRHM-VVHTGRKDFLCQYCAQRFGRKDHLTRHM 232

  Fly   480 ERSHTGEK--------------CCECKICGKVF---------LFEKGLTKHLK------------ 509
            ::||..|.              .|...|..::.         |..|..|..|:
Frog   233 KKSHNQELLKVKTEPMDLLDHFTCGVPIKDELLPVMSLSSSELTSKPFTNSLQLNLYNTQIQSMQ 297

  Fly   510 ----THE------------KRDLPKTQGTNALMGDGASGSSTIAKPSPH----LRGRVERVDIAQ 554
                ||:            ..|:.....::.|.......|::.|...|.    |:|.:|...:..
Frog   298 SSATTHQMVAPTLSLGMPCPIDMDPVHSSHHLSLKYPLNSTSYAVSMPEKEQPLKGEIESYLMEL 362

  Fly   555 LAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCP 619
            .:|.   |..|.:.||.|.::....:.|     ....|.:.||..|....:..           |
Frog   363 QSGM---PPSSQDSPSSSSKLGMNPQVG-----PLDDGSDGVSLSKSSVSISE-----------P 408

  Fly   620 KRFAKKQYLRHHEYIHTGEKPYECKV----CGKHFRQEQVLKTHMKVHDKPPRPPGKPKEPAGP 679
            ...:...:.:...:|.....||....    .|..:..|:       .|...|:.|.:|::|..|
Frog   409 LNASSLDFNQLFNFIPANGPPYNVPASVGNLGMGYSSEE-------AHSSMPQLPPQPQDPQDP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	18/52 (35%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		COG5048	<347..512	CDD:227381	53/204 (26%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	8/20 (40%)
		C2H2 Zn finger	491..511	CDD:275368	5/44 (11%)
		C2H2 Zn finger	586..607	CDD:275368	4/20 (20%)
		C2H2 Zn finger	615..635	CDD:275368	1/19 (5%)
		zf-H2C2_2	627..652	CDD:290200	4/28 (14%)
		C2H2 Zn finger	643..663	CDD:275368	2/23 (9%)
plag1	XP_002934153.1	C2H2 Zn finger	36..56	CDD:275368	4/19 (21%)
		SFP1	<58..139	CDD:227516	27/88 (31%)
		C2H2 Zn finger	64..86	CDD:275368	7/21 (33%)
		C2H2 Zn finger	94..114	CDD:275368	9/24 (38%)
		COG5236	<121..>236	CDD:227561	43/136 (32%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		C2H2 Zn finger	187..207	CDD:275368	5/20 (25%)
		C2H2 Zn finger	215..233	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100