DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and zgc:174268

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017208296.1	Gene:	zgc:174268 / 100001296	ZFINID:	ZDB-GENE-080219-18	Length:	623	Species:	Danio rerio

Alignment Length:	435	Identity:	139/435 - (31%)
Similarity:	202/435 - (46%)	Gaps:	57/435 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 DKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLR 299
            :|..|| |........:|..|..|.:.|.......:||:.|....|:.||  .|.|.||.::.|.
Zfish    43 EKSSRK-IHMMSHTGKKLSTCTQCGKSFTGPSHLNKHMRIHTGEKPYTCT--QCGKSFTQSSNLN 104

  Fly   300 VHVE-HAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALK 363
            .|:: |:..:   :..||:  |.|||.....|:.|: |:|   |.::.|.||:|.:.|...::|.
Zfish   105 EHMKIHSGEK---LFTCTW--CGKSFTLSSYLNKHL-RIH---TGEKPFTCTQCGRSFIRFSSLN 160

  Fly   364 KHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTK 428
            :||..||||. ||.|..|||.|...|.|..|:|.|.|.|.|.|..||.|..|....|:|:|.||.
Zfish   161 QHMVIHTGER-PFTCTQCGKSFTQLSNLNKHMLIHTGEKPHTCTQCGKGFRTSSHLNQHMLIHTG 224

  Fly   429 EKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKI 493
            |:|::|.||.........|..|:: ||.|.|.::|..||::|.......:|::.|||.:...|..
Zfish   225 ERKHKCDQCGKTFRRGPLLKAHLR-VHTKEKPYSCSVCGRSFAAQSNLSLHQKIHTGVREFVCFG 288

  Fly   494 CGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGT 558
            |||.|:....|.:|.:.|              .|:.....|...:...||    |.:.|.:...|
Zfish   289 CGKTFMTAGLLKRHQRIH--------------TGEKPYTCSHCDRRFSHL----ETLKIHERIHT 335

  Fly   559 VANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFA 623
            ...|                     :.|..|||.|:|:..:|.|.: :|...|.:.|..|.|.|.
Zfish   336 GEKP---------------------YACSHCGKTFSHLETLKAHER-IHTGEKPYRCSHCGKTFR 378

  Fly   624 KKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVH--DKP 666
            :.|.|:.|:.|||||||:.|..||:.|.:..:|..|||:|  :||
Zfish   379 QMQTLKAHKRIHTGEKPFSCTQCGQSFTRSSILNEHMKIHTGEKP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	17/52 (33%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	<347..512	CDD:227381	63/164 (38%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	8/20 (40%)
		C2H2 Zn finger	615..635	CDD:275368	7/19 (37%)
		zf-H2C2_2	627..652	CDD:290200	13/24 (54%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
zgc:174268	XP_017208296.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000