DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and znf990

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001032484.1	Gene:	znf990 / 641418	ZFINID:	ZDB-GENE-051113-232	Length:	646	Species:	Danio rerio

Alignment Length:	682	Identity:	166/682 - (24%)
Similarity:	248/682 - (36%)	Gaps:	187/682 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 KNFDLLNVAGNEPELVGQDEEDRINFDPLLDHKMEMIENEEDVFKMLE-------------HVDK 157
            :..||||......:|:.:.|...|..:..| :.:.||..:...|..|:             |:
Zfish    16 EQIDLLNENKEIEDLIKRGENHHIKTEESL-YSISMIRKDNPCFTCLQCANTFSCEENLNLHM-- 77

  Fly   158 EAEQVEKEVKQDELDAADLMTIFAAE-------SSEESEEDIDQ-DVDFEPNSSDGDDDVPLAQR 214
               ::.||||....|..|  .||..|       .:||:..:.|| |..|       .|...||..
Zfish    78 ---KIHKEVKPHNPDQCD--EIFTVEVTNNINVHAEETVYNCDQCDRTF-------TDKRNLAAH 130

  Fly   215 LRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSRRKRIPPGERHLHRIIDCHICHQKFK 279
            ::.:|                            |||.                 ..|.:|.:.|.
Zfish   131 MKFHS----------------------------GEKP-----------------FMCDLCGRSFL 150

  Fly   280 KAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDHAHTELSEVHSCNVDGCGKTFPRIR 344
            .|...::|.|.|:.:....|  ..|.|.|.|...|::|    ||..:.........|||.|..::
Zfish   151 YANTLKKHRKLHSAVKNHVC--SKCGKSFFTYSQLKIH----HTAHATEKPFKCSHCGKGFKSLQ 209

  Fly   345 LLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSA 409
                 .:::|.:..:...|  :.|.:|||.||...:|..||..|.| |.|:.|:.||:.|.....
Zfish   210 -----CQRIHEMIHSGEKP--HKCDQCEKTFRQRKSLNIHMRIHTG-EKPYTCDHCGRSFSRKET 266

  Fly   410 LKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVH 474
            |..||..|:|...|.|..||.|.....::..|:.||..|..|.|..|.....|:.:|..| :.:|
Zfish   267 LNSHLKTHSGNMLYTCAECGEGFNNTGDFTAHMKTHFGENPFLCDQCGKGFPNRTALKKH-QNIH 330

  Fly   475 EKIKNYACQYCGKTF---------------GKSHAC-------------KIHEMTHTGEKRCECK 511
            :.:|::.|..|||||               .:.|.|             |||...|||||...|.
Zfish   331 KGLKDHVCSKCGKTFLTNAILKAHERLHTTERPHKCSHCDKAFKLSQHLKIHVKIHTGEKPYSCD 395

  Fly   512 VCGKKFLYPKSLTKHLKTHEKR-----------VLRAIETYRQRQVEMGETPGEQFDNPPAPPVE 565
            .|||.|...:.|..|::.|.:.           ..|.:.....:.:..||...:|.
Zfish   396 PCGKSFRQKRDLDVHIEKHTEEKPHKCDQCGAGFARKLSLANHKNIHTGENTCDQC--------- 451

  Fly   566 GISIEPIMSRNAADELLKV-----------CAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVS 619
            |:|   ..::::.:..:|:           |..|.|         :|..||.
Zfish   452 GMS---FATKSSLENHMKIHTGEKPFTCDHCEASFA---------RRDSLAN------------- 491

  Fly   620 VPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHE 684
                  .:.....|..|.|..||:.|......|.|. :.|.:.:.:.|..|.|.|.|...||.|.
Zfish   492 ------HIKLHTGENLHKCDQCGKSFRRYDVFKAHL-LTHSRERIYKCNQCDKSFFKPSLLRDHR 549

  Fly   685 WIHTGEKPFECKTCGTHFRQETALKRHQRTHE 716
            .:||.|:|:.|..||..||.:||||.||:.|:
Zfish   550 KVHTDERPYVCYLCGRSFRYKTALKIHQKRHD 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	4/18 (22%)
		C2H2 Zn finger	368..388	CDD:275368	9/19 (47%)
		COG5048	394..729	CDD:227381	97/373 (26%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..474	CDD:275368	5/20 (25%)
		C2H2 Zn finger	482..502	CDD:275368	11/47 (23%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	667..687	CDD:275368	8/19 (42%)
		zf-H2C2_2	680..704	CDD:290200	11/23 (48%)
		C2H2 Zn finger	695..715	CDD:275368	11/19 (58%)
znf990	NP_001032484.1	C2H2 Zn finger	60..80	CDD:275368	2/24 (8%)
		COG5048	110..494	CDD:227381	109/490 (22%)
		C2H2 Zn finger	114..134	CDD:275368	7/26 (27%)
		C2H2 Zn finger	142..162	CDD:275368	6/19 (32%)
		C2H2 Zn finger	170..190	CDD:275368	9/25 (36%)
		C2H2 Zn finger	198..218	CDD:275368	5/24 (21%)
		C2H2 Zn finger	226..246	CDD:275368	9/19 (47%)
		zf-H2C2_2	238..263	CDD:290200	11/25 (44%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..330	CDD:275368	5/20 (25%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		COG5048	362..>646	CDD:227381	64/261 (25%)
		C2H2 Zn finger	366..386	CDD:275368	4/19 (21%)
		zf-H2C2_2	378..403	CDD:290200	13/24 (54%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..442	CDD:275368	1/19 (5%)
		C2H2 Zn finger	448..468	CDD:275368	4/31 (13%)
		zf-H2C2_2	460..485	CDD:290200	4/33 (12%)
		C2H2 Zn finger	476..496	CDD:275368	6/47 (13%)
		C2H2 Zn finger	504..524	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..552	CDD:275368	8/19 (42%)
		C2H2 Zn finger	560..580	CDD:275368	11/19 (58%)
		C2H2 Zn finger	588..608	CDD:275368
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000