DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and zbtb41

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_001922702.4	Gene:	zbtb41 / 573743	ZFINID:	ZDB-GENE-130530-649	Length:	889	Species:	Danio rerio

Alignment Length:	879	Identity:	190/879 - (21%)
Similarity:	305/879 - (34%)	Gaps:	271/879 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VEQSDGFPKCL-CAQCFSRLDDMHEFQKLCVDSVQKF----------QDMVARNVFCPPASAQMK 106
            ::.|.| .||| |::.|:       ::|...:.:.|.          |.:|:.:|.....||:.:
Zfish   172 IQTSSG-TKCLFCSRTFN-------YKKSLENHLAKTHSTGCHNEEEQTVVSTSVVTIRRSARQR 228

  Fly   107 NFDLLNVAGNEPELVGQDEEDR--INFDP---LLDHKMEMIENEEDVFKMLEHVDKEAEQVEKEV 166
            ..        ..:...||.|:.  ::..|   :.:|.....|.||:..:..|  :.|.||:::
Zfish   229 RV--------PAKFKSQDSENECVVSAKPNQKIANHNSVTYEEEEEDNESKE--ENENEQIQQ-- 281

  Fly   167 KQDELDAADLMTIFAAESSEESEEDIDQDVDFEPNSSDGDDDVPLAQRLRDNSRMIPKAKAAVIK 231
                            ||.:|.:|  :..|..|..:::.:|              ..|.|.|.:.
Zfish   282 ----------------ESWKEGQE--ETFVALEVEAAEYED--------------CEKPKEACVS 314

  Fly   232 EEDQEF-PTGSEEEDEDGEKSKSRRKRIPPGERH--LH----RIIDCHICHQKFKKAIRYEEHMK 289
            |..:|. |..|...:|..:|::......|.|...  :|    :.:.|..|.:.|.:..:||.|.:
Zfish   315 EAQKETEPAFSHALEEHNQKTEVSSHIFPEGLAPVVIHSTNKKSLKCPKCDKIFDRKGKYESHTR 379

  Fly   290 HHNDLLPFQCKVETCRKGFTTAGGL--------------------------------------RL 316
            .|....||||.:  |.:.::|...|                                      |.
Zfish   380 VHTGEKPFQCDI--CLQCYSTKSNLTVHKKKHDSGTPVQRKEHKCPFCNKLHASKKTLSRHVKRF 442

  Fly   317 HIDHAHTEL-----SEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFR 376
            |.||....|     |||..|::  |.|:|.|...|..|| .:|      :..:.:.|..|:..|:
Zfish   443 HPDHLQEFLTQKKKSEVWKCDI--CHKSFSRRPHLEEHM-ILH------SQDKPFKCAYCDDYFK 498

  Fly   377 CPMALKKHMYK-HDGKELPFPCNICGKRFVINSALKDHL-MRHAGIKNYVCPYCGVGKTTRQEWN 439
            ...|..||..| |.|   ||||:|||::|......|.|: ..|.|.:.:.|..||.....|....
Zfish   499 SRFARLKHQEKFHLG---PFPCDICGRQFNDTGNRKRHIECTHGGKRKWTCFLCGKSVRERTTLR 560

  Fly   440 THILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTG 504
            .|:..|:.||...|.||..:..:..|...|:::.||. |.|.|:.|||||.:....|.|:..|||
Zfish   561 EHLRIHSGEKPHLCSICGQSFRHGSSYRLHLRVHHED-KRYECEECGKTFIRHDHLKKHKKIHTG 624

  Fly   505 EKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISI 569
            ||..:|:.|||.|.....||.|.|:                :.:||...:::
Zfish   625 EKAHQCEECGKCFRRADHLTVHYKS----------------IHLGEKIWQRY------------- 660

  Fly   570 EPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEG 634
                                                                          |..
Zfish   661 --------------------------------------------------------------KAV 663

  Fly   635 KHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCG 699
            .|.|..|.:.|....|:..|:: .|...|...|..|.:.|:..:||..|..||:..:||.|..|.
Zfish   664 VHQCQVCKKEFRGKTNLMSHFR-THSGEKPHKCVICNQTFSIKKTLTKHMVIHSDVRPFNCPHCS 727

  Fly   700 THFRQETALKRH-QRTH--------ENRPPVISPKFYAAREELEEQERSKREAKRQADAKRREIA 755
            ..|:::..||.| ...|        :|:|  .||     ..:|.:...|.:.:|...:|.:..:.
Zfish   728 ATFKRKDKLKYHVDHVHSVRLLDQQQNQP--ASP-----ANKLIDPSLSNKNSKPCQNASKTVLQ 785

  Fly   756 EAAKE-----QLSSLHKLESSDRSLHSYDEYQEAAAERAAASAELQAQQFEEN-------EVKRL 808
            ..|.:     .|..:...|.:|.::|        ........|..|.||..::       |...|
Zfish   786 SVAADVCVPVTLIPVQMTEEADLAVH--------GVPHGILPALSQPQQSYQSATDLVFLEKYTL 842

  Fly   809 AEEERRKVQEAAYEQLQLLQHQQEVDKAQSSYDG 842
            ..:....|.....||:        :|..:.||.|
Zfish   843 TPQPTNIVHPVRVEQM--------LDPREQSYLG 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	9/47 (19%)
		C2H2 Zn finger	334..353	CDD:275368	7/18 (39%)
		C2H2 Zn finger	368..388	CDD:275368	7/20 (35%)
		COG5048	394..729	CDD:227381	83/344 (24%)
		C2H2 Zn finger	397..417	CDD:275368	7/20 (35%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..474	CDD:275368	5/20 (25%)
		C2H2 Zn finger	482..502	CDD:275368	8/19 (42%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	667..687	CDD:275368	6/19 (32%)
		zf-H2C2_2	680..704	CDD:290200	9/23 (39%)
		C2H2 Zn finger	695..715	CDD:275368	6/20 (30%)
zbtb41	XP_001922702.4	BTB	50..149	CDD:279045
		BTB	62..145	CDD:197585
		C2H2 Zn finger	361..381	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	4/21 (19%)
		C2H2 Zn finger	422..440	CDD:275368	0/17 (0%)
		COG5048	458..774	CDD:227381	105/427 (25%)
		C2H2 Zn finger	462..482	CDD:275368	8/22 (36%)
		C2H2 Zn finger	490..507	CDD:275368	5/16 (31%)
		C2H2 Zn finger	517..538	CDD:275368	7/20 (35%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		zf-H2C2_2	559..583	CDD:290200	7/23 (30%)
		C2H2 Zn finger	574..594	CDD:275368	5/19 (26%)
		zf-C2H2	600..622	CDD:278523	9/21 (43%)
		C2H2 Zn finger	602..622	CDD:275368	8/19 (42%)
		zf-H2C2_2	614..639	CDD:290200	12/24 (50%)
		C2H2 Zn finger	630..651	CDD:275368	9/36 (25%)
		C2H2 Zn finger	667..684	CDD:275368	4/16 (25%)
		zf-H2C2_2	679..703	CDD:290200	6/24 (25%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
		C2H2 Zn finger	723..740	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910