DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10274 and Plag1

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_064353.2	Gene:	Plag1 / 56711	MGIID:	1891916	Length:	499	Species:	Mus musculus

Alignment Length:	390	Identity:	86/390 - (22%)
Similarity:	126/390 - (32%)	Gaps:	159/390 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 ELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHMYKH 388
            :||||........|             |:..|.:|   |.:::||..|:|.|.....||.|.:.|
Mouse     8 DLSEVRDTQKAPSG-------------KRKRGESK---PRKNFPCQLCDKAFNSVEKLKVHSFSH 56

  Fly   389 DGKELPFPC--NICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKF 451
            .| |.|:.|  ..|.|.||                            ::.:...|:.||:.||..
Mouse    57 TG-ERPYKCTHQDCTKAFV----------------------------SKYKLQRHMATHSPEKTH 92

  Fly   452 KCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTH---TGEKRCECKVC 513
            ||:.||...|.|..|.||:.......:.:.|:.|||::......|.|...|   :|:  ..||||
Mouse    93 KCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGD--LTCKVC 155

  Fly   514 GKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAA 578
            .:.|.....|.:|||:|                 .|::.|            |:
Mouse   156 LQNFESTGVLLEHLKSH-----------------AGKSSG------------GV----------- 180

  Fly   579 DELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQ 643
                                                                 ||.||.|..|.:
Mouse   181 -----------------------------------------------------KEKKHQCEHCER 192

  Fly   644 GFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTL-RHHEWIHTGE------------KPFEC 695
            .|....:::|| .::|...|||.|::|.:||.:...| ||.:..|..|            .||.|
Mouse   193 RFYTRKDVRRH-MVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTC 256

Fly 696 695
Mouse 257 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	2/18 (11%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		COG5048	394..729	CDD:227381	66/320 (21%)
		C2H2 Zn finger	397..417	CDD:275368	5/21 (24%)
		C2H2 Zn finger	425..445	CDD:275368	1/19 (5%)
		C2H2 Zn finger	453..474	CDD:275368	8/20 (40%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	667..687	CDD:275368	7/20 (35%)
		zf-H2C2_2	680..704	CDD:290200	8/29 (28%)
		C2H2 Zn finger	695..715	CDD:275368	1/1 (100%)
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/40 (23%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		27/120 (23%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	7/19 (37%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		71/325 (22%)
		SFP1	<58..139	CDD:227516	27/109 (25%)
		C2H2 Zn finger	64..86	CDD:275368	6/49 (12%)
		zf-H2C2_2	79..103	CDD:404364	9/23 (39%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		C2H2 Zn finger	187..207	CDD:275368	5/20 (25%)
		C2H2 Zn finger	215..233	CDD:275368	7/17 (41%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		3/14 (21%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..400
		Massively activates transcription. /evidence=ECO:0000250	384..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100