DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10274 and LOC563292

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_021332054.1	Gene:	LOC563292 / 563292	-ID:	-	Length:	749	Species:	Danio rerio

Alignment Length:	774	Identity:	182/774 - (23%)
Similarity:	267/774 - (34%)	Gaps:	257/774 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SVQKF-----------QDMVARNVFCPPASAQMKNFDLLNVAGNEPE-------------LVGQD 124
            |||.|           :|:||..|.|...........::::.|.|.|             :.|::
Zfish    54 SVQGFSSDELVIQDAVEDVVAEYVHCDDDEGVAVETCVMSLEGEEEEDGVAMAEMTEDVLVEGRE 118

  Fly   125 EEDRINFDPLLDHKMEMIENEEDVFKML----EHVDKEAEQVEKEVKQDELDAADLMT--IFAAE 183
            :|.  :.|...|:.|..:   :|..||:    :.|..|....::||::|| |..:::.  ||.|:
Zfish   119 QEH--DSDSCGDYLMISL---DDAGKMVSGDGDEVTVEGAIDDQEVEKDE-DGQEVIKVYIFKAD 177

  Fly   184 SSEESEEDIDQDVDFEPNS----------------------------------SD---------G 205
            |   .|:|:.:.||...|.                                  ||         |
Zfish   178 S---GEDDLGETVDLGENETVALAEPVVRPLREKIYMSVGDGHHTQTDGGSKLSDEVYMEVVVGG 239

  Fly   206 DDDVPLAQRLRDNSRM----IPKAKAAVIKEEDQ--EFPTGS-------EEEDE----DGEKSKS 253
            ::.|| ..|..|::.:    :|.|.||.....|:  |...|:       :|.|.    :.:..|:
Zfish   240 EEPVP-HDRPYDSTALSKDFMPVAWAAAYAGADEGCENRNGAASALLHIDESDALDKLNRQHGKN 303

  Fly   254 RRKRIP----------PGERHLHRIIDCHICHQKFKKAIRYEEHMK-HHNDLL------------ 295
            ||:..|          |..:.| .:..|.:|.:|||.....:.|.: ||.|:|
Zfish   304 RRRAEPRQVQTAIIIGPYGQPL-TVYPCMLCGKKFKSRGFLKRHTRNHHQDVLTRKKYQCTDCDF 367

  Fly   296 ---------------------PFQCKVETCRKGFTTAGGLRLH-IDHAHTE-------------- 324
                                 ||:|  |||.|.|.....|..| :.|.|.|
Zfish   368 TTNKKASLHNHMEVHALSNKAPFEC--ETCGKEFHQQAALFSHRLQHHHREQKTPTAIASPLPPA 430

  Fly   325 -LSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYP--CTECEKVFRCPMALKKHMY 386
             .::.|.|..  |........||..|:..:|.        :.:|  |.||.|.||.|..|||||.
Zfish   431 TANKTHKCKF--CDYETAEQGLLNRHLLAVHS--------KSFPHICVECGKGFRHPSELKKHMR 485

  Fly   387 KHDGKELPFPCNICGKRFVINSALKDHL-MRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKK 450
            .|.| |.|:.|..|..:...:|.||.|: .:|:....:.|..||......:|...|..||...:.
Zfish   486 THTG-EKPYSCMYCDYKSADSSNLKTHVKTKHSRELPFRCERCGQTFAEEEELTQHATTHDDARG 549

  Fly   451 FKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGK 515
            .:|..|:|.|.|...|..||..||.|...:.|..|.|.|.:....|.|..:|..:|..:|:.|..
Zfish   550 HQCSHCDHRSSNSSDLKRHIISVHTKDYPHKCAVCAKGFHRPSELKKHSASHKAKKMHQCRHCNF 614

  Fly   516 KFLYPKSLTKH-LKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPP-----APPVEGISIEPIMS 574
            |...|..|::| |..|.|              |..:|..:|...||     |||.|
Zfish   615 KISDPFVLSRHILSVHTK--------------EPQQTAQQQQQTPPTSPQQAPPTE--------- 656

  Fly   575 RNAADELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEG----- 634
                               |.|...:.:..||||..||                  ||.|
Zfish   657 -------------------KSPAPKRTIGAAQLAAPAV------------------KKAGGAKGQ 684

  Fly   635 ----KHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAK-----AQTLRHHE 684
                .:.|..|.....:....|||...||.|.....|::|.|.|.:     ...:|||:
Zfish   685 RERRVYQCQYCDYSTGDASGFKRHVISIHTKDYPHRCQYCSKGFRRPSEKNQHIMRHHK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	4/16 (25%)
		C2H2 Zn finger	334..353	CDD:275368	4/18 (22%)
		C2H2 Zn finger	368..388	CDD:275368	12/19 (63%)
		COG5048	394..729	CDD:227381	78/312 (25%)
		C2H2 Zn finger	397..417	CDD:275368	6/20 (30%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..474	CDD:275368	8/20 (40%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	7/20 (35%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	667..687	CDD:275368	7/23 (30%)
		zf-H2C2_2	680..704	CDD:290200	3/5 (60%)
		C2H2 Zn finger	695..715	CDD:275368
LOC563292	XP_021332054.1	Zfx_Zfy_act	43..313	CDD:309717	56/268 (21%)
		ROS_MUCR	<330..360	CDD:327679	10/29 (34%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		C2H2 Zn finger	392..412	CDD:275368	8/21 (38%)
		C2H2 Zn finger	438..459	CDD:275368	5/22 (23%)
		COG5048	463..>518	CDD:227381	24/55 (44%)
		C2H2 Zn finger	467..487	CDD:275368	12/19 (63%)
		C2H2 Zn finger	495..516	CDD:275368	6/20 (30%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		C2H2 Zn finger	581..601	CDD:275368	6/19 (32%)
		C2H2 Zn finger	609..626	CDD:275368	5/16 (31%)
		C2H2 Zn finger	692..713	CDD:275370	5/20 (25%)
		C2H2 Zn finger	721..741	CDD:275370	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910