DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and plag1

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001034903.1	Gene:	plag1 / 561450	ZFINID:	ZDB-GENE-060302-2	Length:	393	Species:	Danio rerio

Alignment Length:	351	Identity:	80/351 - (22%)
Similarity:	134/351 - (38%)	Gaps:	81/351 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 RKRIPPGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHID 319
            |||...|:  :.:...|.:|.:.|....:.:.|...|....|:.|....|.|.|.:...|..|:
Zfish    19 RKRREEGK--VRKNFSCQLCEKAFNSLEKLKVHSYSHTGERPYHCTHTDCTKAFVSKYKLLRHM- 80

  Fly   320 HAHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKH 384
             |.....:.|.|:.  |.|.|.|...|..|: ..|...|.|     :.||||:|.:...:..::|
Zfish    81 -ATHSPEKTHKCSY--CEKMFHRKDHLKNHL-HTHDPNKEA-----FSCTECDKSYNTKLGFRRH 136

  Fly   385 MYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEK 449
            ...|..:.....|.:|.:.:.....|.:||..||            ||:.         |.|:||
Zfish   137 QALHAAQRGDLTCQVCLQSYPSTPLLLEHLRGHA------------GKSA---------TATKEK 180

  Fly   450 KFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCG 514
            :.:|..||...:.::.:..|: :||...|::.||||.:.||:    |.|
Zfish   181 RHQCDQCERRFYTRKDVRRHL-VVHTGRKDFLCQYCAQRFGR----KDH---------------- 224

  Fly   515 KKFLYPKSLTKHL-KTHEKRVLRAIETYRQRQVEMGETPGEQFDNP-------------PAPPVE 565
                    ||:|: |:|...:||.    :...|::.|:.......|             |.||:.
Zfish   225 --------LTRHVKKSHAHELLRV----KAEPVDLMESQSLPTSGPLTLRYPLAHASYSPPPPLR 277

  Fly   566 GISIEPIMSRNAADELLKVCAESVAT 591
            . .:|..:....|::..|:.:.:..|
Zfish   278 A-ELESYLLELQAEDTPKLSSSTTVT 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	6/18 (33%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		COG5048	394..729	CDD:227381	45/212 (21%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	2/19 (11%)
		C2H2 Zn finger	453..474	CDD:275368	4/20 (20%)
		C2H2 Zn finger	482..502	CDD:275368	8/19 (42%)
		C2H2 Zn finger	510..530	CDD:275368	4/20 (20%)
		C2H2 Zn finger	638..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	680..704	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
plag1	NP_001034903.1	COG5048	29..>99	CDD:227381	17/73 (23%)
		C2H2 Zn finger	33..53	CDD:275368	4/19 (21%)
		C2H2 Zn finger	61..83	CDD:275368	7/23 (30%)
		zf-H2C2_2	76..100	CDD:290200	8/27 (30%)
		C2H2 Zn finger	91..111	CDD:275368	7/22 (32%)
		C2H2 Zn finger	120..140	CDD:275368	6/19 (32%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		C2H2 Zn finger	184..204	CDD:275368	4/20 (20%)
		C2H2 Zn finger	212..230	CDD:275368	11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100