DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10274 and PLAG1

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001108106.1	Gene:	PLAG1 / 5324	HGNCID:	9045	Length:	500	Species:	Homo sapiens

Alignment Length:	363	Identity:	83/363 - (22%)
Similarity:	119/363 - (32%)	Gaps:	146/363 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 KKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPC--NICGKRFVINSALKDH 413
            |:..|.||   |.:::||..|:|.|.....||.|.|.|.| |.|:.|  ..|.|.||
Human    22 KRKRGETK---PRKNFPCQLCDKAFNSVEKLKVHSYSHTG-ERPYKCIQQDCTKAFV-------- 74

  Fly   414 LMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIK 478
                                ::.:...|:.||:.||..||:.||...|.|..|.||:.......:
Human    75 --------------------SKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKE 119

  Fly   479 NYACQYCGKTFGKSHACKIHEMTH---TGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIET 540
            .:.|:.|||.:......|.|...|   :|:  ..||||.:.|.....|.:|||:|
Human   120 TFKCEECGKNYNTKLGFKRHLALHAATSGD--LTCKVCLQTFESTGVLLEHLKSH---------- 172

  Fly   541 YRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLA 605
                   .|::.|            |:
Human   173 -------AGKSSG------------GV-------------------------------------- 180

  Fly   606 QLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFC 670
                                      ||.||.|..|.:.|....:::|| .::|...|||.|::|
Human   181 --------------------------KEKKHQCEHCDRRFYTRKDVRRH-MVVHTGRKDFLCQYC 218

  Fly   671 PKRFAKAQTL-RHHEWIHTGE------------KPFEC 695
            .:||.:...| ||.:..|..|            .||.|
Human   219 AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTC 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	1/1 (100%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		COG5048	394..729	CDD:227381	66/320 (21%)
		C2H2 Zn finger	397..417	CDD:275368	5/21 (24%)
		C2H2 Zn finger	425..445	CDD:275368	1/19 (5%)
		C2H2 Zn finger	453..474	CDD:275368	8/20 (40%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	667..687	CDD:275368	7/20 (35%)
		zf-H2C2_2	680..704	CDD:290200	8/29 (28%)
		C2H2 Zn finger	695..715	CDD:275368	1/1 (100%)
PLAG1	NP_001108106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		4/10 (40%)
		Interaction with KPNA2. /evidence=ECO:0000269\|PubMed:11882654	2..84		24/93 (26%)
		Nuclear localization signal	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	8/19 (42%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		72/325 (22%)
		SFP1	<58..139	CDD:227516	27/109 (25%)
		C2H2 Zn finger	64..86	CDD:275368	6/49 (12%)
		zf-H2C2_2	79..103	CDD:404364	9/23 (39%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		C2H2 Zn finger	187..207	CDD:275368	5/20 (25%)
		C2H2 Zn finger	215..233	CDD:275368	7/17 (41%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500		3/14 (21%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010