DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and CG11247

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	142/694 - (20%)
Similarity:	220/694 - (31%)	Gaps:	241/694 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 KEAEQVEKEVKQDELDAADLMTIFAAESSEESEEDIDQDVDFEPNSSDGDDDVPLAQRLRDNSRM 221
            :....|.||      ||..|:|            |....:...|.:.:......||.:.|.:|
  Fly     3 RSRRSVSKE------DAVSLLT------------DSGISLSSPPAARESSPGPTLAIKRRKSS-- 47

  Fly   222 IPKAKAAVIKEEDQEFPTGSEEEDEDG-----EKSKSRRKRIPPGERHLHRIIDCHICHQ---KF 278
            :...:.|.:.||:.:   |.|::.:|.     :..||.||..|...:|       |:|.|   :|
  Fly    48 LASLRDACVDEEEDD---GGEQDSKDDDYVQPQLKKSARKGEPVKRKH-------HVCSQCSKEF 102

  Fly   279 KKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDHAHTELSEVHSCNVDGCGKTFPRI 343
            ......:.||..|:|..|.:||  .|.|.:..|..|:.||..||.
  Fly   103 GGKTDLQRHMLIHSDERPHKCK--DCGKSYRQAVNLKNHITTAHE-------------------- 145

  Fly   344 RLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINS 408
                 |.|:             :.|::|.|.|.....|:.||..|.| |.|:||::|.|:|....
  Fly   146 -----HRKQ-------------FVCSQCPKSFALKERLRLHMRLHSG-EKPYPCDLCDKKFARGG 191

  Fly   409 ALKDHLMRH--AGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIK 471
            .|:.|::.|  ..|:.:.|..|....:|......|:..|.|..:.:|.|||:...|:.:|..||.
  Fly   192 QLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHIN 256

  Fly   472 IVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLR 536
            ..|.|:..:.|:.|.|..........|...||..|...|:||...|........|::.|
  Fly   257 QEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMH------ 315

  Fly   537 AIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQR 601
                       .||.|
  Fly   316 -----------TGERP------------------------------------------------- 320

  Fly   602 VDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFA 666
                                                                           :.
  Fly   321 ---------------------------------------------------------------YQ 322

  Fly   667 CRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTH--FRQETALKRH-QRTHENRPPVISP---K 725
            ||.|.:.||.:..|:.|...|||||||.|:.|...  |.|...||.| ::.|:.:.|.:..   .
  Fly   323 CRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHD 387

  Fly   726 FYAAREELEEQERSKREAKRQADAKRREIAEAAKEQLSSLHKLESSDRSLHSYDEYQEAAAERAA 790
            |:..:.||  |...:..||...|..:..             ..:|.|..:.|...:..|...:..
  Fly   388 FFKIKVEL--QSHVEHCAKCPVDGDKPS-------------GNQSEDAQILSVLRFNMAVVLKKI 437

  Fly   791 ASAELQAQQFEENEVKRLAEEERRKVQEAAYEQLQLLQHQQEVD 834
            :||:         ::::|. .|:|.:.......|:|.|.|...|
  Fly   438 SSAQ---------KLRQLG-YEKRLIDNVIIASLKLAQRQSHDD 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	2/18 (11%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		COG5048	394..729	CDD:227381	66/342 (19%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	8/20 (40%)
		C2H2 Zn finger	482..502	CDD:275368	4/19 (21%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	0/20 (0%)
		C2H2 Zn finger	667..687	CDD:275368	7/19 (37%)
		zf-H2C2_2	680..704	CDD:290200	12/25 (48%)
		C2H2 Zn finger	695..715	CDD:275368	7/22 (32%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/206 (25%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	9/26 (35%)
		C2H2 Zn finger	123..144	CDD:275368	8/22 (36%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/24 (50%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/305 (18%)
		C2H2 Zn finger	210..230	CDD:275370	4/19 (21%)
		C2H2 Zn finger	238..260	CDD:275371	8/21 (38%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	9/151 (6%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930