DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and CG7386

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	378/774 - (48%)
Similarity:	501/774 - (64%)	Gaps:	117/774 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QYSVHAVCRICLNRLPENGGGAGSFDLFLIPGLAKKLCVCTSLAVEQSDGFPKCLCAQCFSRLDD 73
            :|||.::|..||..|..   ||| .|||::|.|.:||..|||...:|:||||:.||.|||::|:|
  Fly     4 KYSVQSLCLTCLVHLKH---GAG-HDLFVVPDLFQKLRACTSFDADQNDGFPRNLCTQCFTKLND 64

  Fly    74 MHEFQKLCVDSVQKFQDMVA--RNVFCPPASAQMKNFDLLNVAGNEPELVGQDEEDRINFDPLLD 136
            :|:|::||.:|:::.::|:.  ||:       .|..|:.:......||    ..|:..:|||||:
  Fly    65 LHDFRELCAESIKRLKEMMTSQRNM-------PMGVFESIADDSEAPE----RPEEPASFDPLLN 118

  Fly   137 HKMEMIENEEDVFKMLEHVDKEAEQVEKEVKQDELDAADLMTIFAAESSEESEEDIDQDVDFEPN 201
            :|:|||:|||||||:||.||||.|:                     .|.::|||      .|...
  Fly   119 NKLEMIDNEEDVFKLLEKVDKELEE---------------------HSRDQSEE------HFSSA 156

  Fly   202 SSDGDDDVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSRRKRIPPGERHLH 266
            ..:|                        ::||.:|    ||..:.|.|::..:| ||...:|.|.
  Fly   157 EHNG------------------------LEEEKKE----SEGFNSDDEQAMGQR-RIANDKRKLF 192

  Fly   267 RIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDHAHTELSEVHSC 331
            |::.|.||.|||||..::|||||||||||||||:.|:|||||||||.||||:|:||::..:...|
  Fly   193 RLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPC 257

  Fly   332 NVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFP 396
            .|:||...|.|:||||.|:||:|...:..||..:..|.||..|||||:|:|||||.|.|:|||:|
  Fly   258 TVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYP 322

  Fly   397 CNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASH 461
            |.||||.|.||||||:||:||||||||||.||||.|||||||:.|||.|||..:|||.||::|:|
  Fly   323 CTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATH 387

  Fly   462 NKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKH 526
            .|:.|.:|:|||||||:|:|||||||||||::|||||||.||||||||||||.||||:.:||..|
  Fly   388 TKRVLESHVKIVHEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNH 452

  Fly   527 LKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVAT 591
            ||.|||.|.||:|||:|.||. |:....|.|                    :.:||||.|||||:
  Fly   453 LKIHEKSVERALETYKQVQVN-GDASDTQVD--------------------SHQLLKVYAESVAS 496

  Fly   592 IPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYK 656
            |||:||||::||:|.||||||||         :.::.|.:|||.::||.|.|||.:|||||||||
  Fly   497 IPKNPRRVEQVDVALLAGTAVNP---------TDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYK 552

  Fly   657 IIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETALKRHQRTHENRPPV 721
            .:|||||||.||||.:|||.:|:::.|||||||||||||||||..|||..||.|||:.|:.:|
  Fly   553 SVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVAALIRHQKVHDEKP-- 615

  Fly   722 ISPKFYAAREELEEQERSKREAKRQADAKRREIAEAAKEQLSSLHKLESSDRSLHSYDE 780
                   |:...|..:|     |::.:|.|:|||:.||::|..|....:.::...:|::
  Fly   616 -------AKPLGERNDR-----KQKVEALRQEIAKVAKKELKDLKNQLALEKQQDTYEK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	34/74 (46%)
		C2H2 Zn finger	334..353	CDD:275368	10/18 (56%)
		C2H2 Zn finger	368..388	CDD:275368	14/19 (74%)
		COG5048	394..729	CDD:227381	203/334 (61%)
		C2H2 Zn finger	397..417	CDD:275368	14/19 (74%)
		C2H2 Zn finger	425..445	CDD:275368	15/19 (79%)
		C2H2 Zn finger	453..474	CDD:275368	10/20 (50%)
		C2H2 Zn finger	482..502	CDD:275368	17/19 (89%)
		C2H2 Zn finger	510..530	CDD:275368	13/19 (68%)
		C2H2 Zn finger	638..659	CDD:275368	15/20 (75%)
		C2H2 Zn finger	667..687	CDD:275368	11/19 (58%)
		zf-H2C2_2	680..704	CDD:290200	18/23 (78%)
		C2H2 Zn finger	695..715	CDD:275368	13/19 (68%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	34/74 (46%)
		C2H2 Zn finger	197..217	CDD:275368	13/19 (68%)
		C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		C2H2 Zn finger	351..371	CDD:275368	15/19 (79%)
		C2H2 Zn finger	379..400	CDD:275368	10/20 (50%)
		C2H2 Zn finger	408..428	CDD:275368	17/19 (89%)
		C2H2 Zn finger	436..456	CDD:275368	13/19 (68%)
		C2H2 Zn finger	534..555	CDD:275368	15/20 (75%)
		C2H2 Zn finger	563..583	CDD:275368	11/19 (58%)
		zf-H2C2_2	575..600	CDD:290200	18/24 (75%)
		C2H2 Zn finger	591..611	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449735
Domainoid	1	1.000	97	1.000	Domainoid score	I7185
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77239
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.990