DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and pita

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	169/863 - (19%)
Similarity:	294/863 - (34%)	Gaps:	247/863 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EAEAAQYSVHAVCRICLNR------LPENGGGAGSFDLFLIPGLAKKLCVCTSLAVEQSDGFPKC 62
            |...|..:...|||.||..      ..||.....:.:|.|      ::...|::.|...||.|..
  Fly     6 EVREAMLTEKRVCRFCLTEQKLASIFEENPRVKTTANLPL------QIMAITAIEVYAGDGMPGH 64

  Fly    63 LCAQCFSRLDDMHEFQKLCVDSVQKFQDMVARNVFCPPASAQMKNFDLLNVAGNEPELVGQDEED 127
            :|.:|           :|..:...:|:.|      |..|...::.:.|   .||.|..:   |:.
  Fly    65 ICLEC-----------RLLFEHCYRFKQM------CKRAETLLRQYPL---TGNWPSPL---EKP 106

  Fly   128 RINFDPLLDHKMEMIENEEDVFKMLEHVDKEAEQVEKEVKQDELDAADLMTIFAAESSEESEEDI 192
            |.        .|.|:.::    |:|....|.||..|...|        |:...|..||:...||:
  Fly   107 RA--------PMTMVASK----KLLVVPAKTAEPSETPKK--------LLNTMAKSSSQVIIEDV 151

  Fly   193 D--QDVDFEPNSSDGDDDVPL---AQRLR-DNSRMIPKAKAAVIKEE-----DQEFPTGSEEEDE 246
            .  :.....|.:..|...||.   |..|: ||::.:.......:.|:     ::|||
  Fly   152 QVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQELSMDDVQSMLEDMASELEKEFP-------- 208

  Fly   247 DGEKSKSRRKRIPPGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTA 311
                 ...:|..|...:.|:            |.:||    :.:.....|.:.::.|.:.....:
  Fly   209 -----DIPQKASPVKPKVLN------------KSSIR----ILNKGPAAPVEPRLATPKVKRDDS 252

  Fly   312 GGLRLHIDHAHTEL----------------SEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAA 360
            |.:.:..:...::|                ::|..|  ..|.::||..:||..| :..|  |::
  Fly   253 GNVAIVTEVLDSDLPLDDQDDPTKNAEKVATDVFPC--PDCERSFPLQQLLEIH-RLNH--TRS- 311

  Fly   361 APPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVC 425
               |.:.|..|||.|.....|.||.:.|.| |.||.|.||.|.|...:.|..|...|..:..::|
  Fly   312 ---RSFQCLLCEKSFFSKYDLAKHNFVHTG-ERPFKCAICSKAFTRKALLHRHERTHTDVPKFIC 372

  Fly   426 PYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFG 490
            .||.....:|||...|...|.:::.|:|.:|..:...||.|..| :.||.....:.||:|.::|.
  Fly   373 VYCEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERH-ETVHSTNLPFPCQHCERSFS 436

  Fly   491 KSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQ 555
            .:.....|.:.|.|::...||.|.|.::....|::||:||.:
  Fly   437 TASKLARHLVAHAGKRAYPCKYCHKSYMLSHHLSRHLRTHTQ----------------------- 478

  Fly   556 FDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSV 620

  Fly   479 ----------------------------------------------------------------- 478

  Fly   621 PSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEW 685
                      ..:...:|..|...::|..::..| .:|| ......|..|.|:.....::..|..
  Fly   479 ----------TSDASFVCSECKVSYSNYNDLLDH-ALIH-ATASLKCPMCRKQIEDIDSVESHMD 531

  Fly   686 IHTGEKPFECKTCGTHFRQETALKRH-QRTHENRPPVISPKFYAAREE--------LEEQERSKR 741
            .|...:...|:.|...|..:..|:|| :..|     |:..:.|....|        ::|:|....
  Fly   532 QHKQSERHACEFCDHIFLTQKCLQRHIEDDH-----VVEMEPYQNEFEDDGEGEGGVDEKEEHLD 591

  Fly   742 EAKRQADAKRRE-IAEAAKEQLSSLHKLESSD----------RSLHSYDEYQEAAAERAAASAEL 795
            :.:...:.|:.| :.|..::.......|:.||          |..:...:.|::..:..:..|:.
  Fly   592 DFEDMDNVKQEEFVTEYLEDDALYEDHLDDSDESFTPPPPKQRKTNPPKDAQQSVRQTRSRDAQR 656

  Fly   796 QAQQFEENEVKRLAEEER 813
            ..|:..:||.|...:.||
  Fly   657 ITQKTGKNEGKPHHKLER 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	18/80 (23%)
		C2H2 Zn finger	334..353	CDD:275368	6/18 (33%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		COG5048	394..729	CDD:227381	63/335 (19%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..474	CDD:275368	6/20 (30%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	667..687	CDD:275368	4/19 (21%)
		zf-H2C2_2	680..704	CDD:290200	5/23 (22%)
		C2H2 Zn finger	695..715	CDD:275368	6/20 (30%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	21/97 (22%)
		COG5048	<281..506	CDD:227381	69/334 (21%)
		C2H2 Zn finger	288..308	CDD:275368	7/22 (32%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	13/25 (52%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..388	CDD:275370	6/15 (40%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..506	CDD:275368	4/20 (20%)
		HARE-HTH	<566..625	CDD:294801	10/58 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930