DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and CG11906

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_611402.2	Gene:	CG11906 / 37209	FlyBaseID:	FBgn0034425	Length:	634	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	123/691 - (17%)
Similarity:	214/691 - (30%)	Gaps:	215/691 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 DFEPNSSDGDDDVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSRRKRIPPG 261
            |.||:|::|:..|.     .||            :::..|...|:|.|.|..:
  Fly     8 DPEPSSTNGNCSVE-----HDN------------RQDQDENHVGAEREAEAND------------ 43

  Fly   262 ERHLHRIIDCHICHQKFKKAI-----------RYEEHMKHHNDLLPFQCK---VE-TCRKGFTTA 311
                   .:|.:|......|:           |.....|.|.|::....|   || .|:
  Fly    44 -------ANCTVCGAAKASALLDLRSNHVMQRRLSRDWKIHADVIRSTLKAICVECVCK------ 95

  Fly   312 GGLRLHIDHAHTELSEVHSCNVDGCGKT-------------FPRI---RLLTFHMKKMHGITKAA 360
              |.:|.:...:.:..:......| |:|             .|.|   .:.|..::....:..:.
  Fly    96 --LNMHSEVTRSLMQRMQRLQRSG-GETTKVTTTTTSPSQHSPPIADAEVSTTLIESQEEVAHSG 157

  Fly   361 APPRDYPCTECEKVFRCPMALKKHMYKHDGKELP------------FPCNICGKRFVINSALKDH 413
            ...|........:|:     |.:..|....||..            ..|:.||:.:........|
  Fly   158 QSVRSRSSCSVLEVY-----LAQQPYSPSAKETEEKHAEGWKWRTRLECHECGRAYFRRDYYAQH 217

  Fly   414 LMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIK 478
            |.|           |  .||.|::        .:..:.||.:...||:::::.:..|:    ..:
  Fly   218 LRR-----------C--SKTRRKQ--------PRPSRVKCRVLNEASYDEEAPSRAIR----SSR 257

  Fly   479 NYACQYCGKTFGKSHACKIHE-MTHTGEKRCECKVCGKKF--LYPKSLTKHLKTHEKRVLRAIET 540
            .|.|::|...|....:.:.|| |.|  ::|..|.:|..:.  .|...:...:...::..|..:|
  Fly   258 IYYCRHCDAEFETLISKRQHERMKH--QQRYPCDLCEAQLDTKYEWEMHHTICQAKQEALAIVE- 319

  Fly   541 YRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLA 605
                |.|.|:|               :....:....:.....:.|:|:......|.......| .
  Fly   320 ----QQEAGQT---------------VMTSRVPRACSMRSRSRACSEAWDRYDMDEEEEDEED-E 364

  Fly   606 QLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMK----------------RH 654
            ::...............::.::|||   |..|........|:.||:.                :.
  Fly   365 EIESGGEELEEGEEDAMYARRMNFT---GDWIVNHSRSNSNSAGNLSLLYGDYGMVETHMTTDKE 426

  Fly   655 YKI-------IHEKVKDFACRFCPKRFAKAQTL----RHHEWIHTGEKPFECKTCGTHFRQETAL 708
            |.:       ...::|.|.| |.|....:..||    :|....|.....|.|..||..|..:..|
  Fly   427 YDLYLLDLLKTQVRLKSFTC-FTPDCGYQTDTLVALMKHDYMEHWKMSWFYCHKCGDVFTSKVFL 490

  Fly   709 KRHQRTHENRPPVISPKFYAAREELEEQERSKR----------------------EAKRQADAKR 751
            ..|... :||...|..|   .|||.|.|.:..|                      |||..|..|:
  Fly   491 DYHMHL-QNRGLYICHK---CREEFELQHQLDRHFQLHRKGINYHCNFCRLEFLSEAKLLAHCKK 551

  Fly   752 REIAEAAKEQ----------LSSLHKLESSD--RSLHSYDE 780
              :..:..::          :.:.|...|||  |.:.||:|
  Fly   552 --LGHSPNDEPLISIDRSLSIVNCHVPRSSDYSRIVKSYEE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	6/34 (18%)
		C2H2 Zn finger	368..388	CDD:275368	3/19 (16%)
		COG5048	394..729	CDD:227381	66/376 (18%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	4/20 (20%)
		C2H2 Zn finger	482..502	CDD:275368	6/20 (30%)
		C2H2 Zn finger	510..530	CDD:275368	3/21 (14%)
		C2H2 Zn finger	638..659	CDD:275368	4/43 (9%)
		C2H2 Zn finger	667..687	CDD:275368	6/23 (26%)
		zf-H2C2_2	680..704	CDD:290200	8/27 (30%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
CG11906	NP_611402.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100