DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10274 and CG2202

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	150/736 - (20%)
Similarity:	233/736 - (31%)	Gaps:	268/736 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VCRICLNRLPENGGGAGSFDLFLI---------PGLAKKLCVCTSLAVEQSDGFPKCLCAQCFSR 70
            |||:||..:...|      :|..|         ..||:.|..||....|::||.|..:|:.|...
  Fly    45 VCRVCLKDVSLEG------ELHFIFNETPVEQDANLARILDECTLHQCERNDGMPPHMCSSCVEA 103

  Fly    71 LDDMHEFQK---------------------------------------LCVD------SVQKFQD 90
            ..:.:.|::                                       :|.|      .::..::
  Fly   104 ARNAYRFKRHAERSYCSLVALLGRSPQLKARGAEAASQTDQVALLPCEMCHDQFLNSLELRLHRN 168

  Fly    91 MVARNV-------------------FC-------------------------------------- 98
            .|.|..                   ||
  Fly   169 QVHRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQTARLQCAHCQRTFSRRDH 233

  Fly    99 --------------------PPASAQMKNFD----------LLNVAGNEPELVGQ---------- 123
                                |||.....|.|          |||...||.|:||:
  Fly   234 LLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPIS 298

  Fly   124 -DEED-------------RINFDPLLDHKMEMIENEEDVFKML---------EHVDKEAE-QVEK 164
             :|:|             .|..:|.|:      ..|.|:...|         |..:.:|| .:::
  Fly   299 SNEDDGEEANGANQTLWLHIKPEPCLE------AEEVDLAMQLKLEKKRRRREKAEAQAETSIDR 357

  Fly   165 EVKQDEL-------------------DAA-----DLMTI-------------FAAESSEESEEDI 192
            .||.:.:                   |.|     |.|.:             |...:.::|:.|.
  Fly   358 TVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLDD 422

  Fly   193 DQDVDFEPNSSDGDD-DVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSRRK 256
            |.|.|.|.::.|.|| :..|.|...|..:.:.|||:                    |.:.:.|.|
  Fly   423 DDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKS--------------------GRRRRRRNK 467

  Fly   257 RIP-PGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDH 320
            ..| |..|       |.:|.:.|.:......|...|.:..|..|  ..|.|.|..:..|:.|:..
  Fly   468 DEPNPDNR-------CEVCQRTFSRHCHLLRHKLSHLEKKPHNC--PHCPKAFARSDHLKAHVQS 523

  Fly   321 AHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMH---GI---TKAAAPPRDYPCTECEKVFRCPM 379
            .|:  ::.|.|::  |...|.|:..|..|....|   |:   ::......::.|..|.|.|....
  Fly   524 LHS--NKEHKCSL--CEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKT 584

  Fly   380 ALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILT 444
            .|:||...|  .:..:.|..|.:.|...:.|::|...|.|.:|::|..||...........|:..
  Fly   585 YLRKHTLLH--TDFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRR 647

  Fly   445 HTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCE 509
            |..||.:||..|..|......|..|.: .|...|...|..|||:|.:::...||..|||||:..:
  Fly   648 HNGEKPYKCRFCVKAFPRATDLKVHER-YHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYK 711

  Fly   510 CKVCGKKFLYPKSLTKHLKTH 530
            |..|.|.|.....|..|::.|
  Fly   712 CDQCPKSFTQSNDLKAHIRRH 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	22/128 (17%)
		C2H2 Zn finger	334..353	CDD:275368	5/18 (28%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		COG5048	394..729	CDD:227381	42/137 (31%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	5/20 (25%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	680..704	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	20/81 (25%)
		C2H2 Zn finger	150..171	CDD:275368	2/20 (10%)
		C2H2 Zn finger	192..213	CDD:275370	2/20 (10%)
		C2H2 Zn finger	221..239	CDD:275370	0/17 (0%)
		COG5048	<443..730	CDD:227381	82/322 (25%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		zf-H2C2_2	488..513	CDD:290200	7/26 (27%)
		C2H2 Zn finger	504..525	CDD:275368	6/22 (27%)
		C2H2 Zn finger	532..548	CDD:275368	5/17 (29%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..637	CDD:290200	8/23 (35%)
		C2H2 Zn finger	628..648	CDD:275368	4/19 (21%)
		zf-H2C2_2	640..663	CDD:290200	7/22 (32%)
		C2H2 Zn finger	656..676	CDD:275368	5/20 (25%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	11/24 (46%)
		C2H2 Zn finger	712..732	CDD:275368	6/19 (32%)
		C2H2 Zn finger	739..755	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100