DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10274 and Plag1

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001008317.1	Gene:	Plag1 / 297804	RGDID:	1305286	Length:	499	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	84/363 - (23%)
Similarity:	130/363 - (35%)	Gaps:	118/363 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 GSEEEDEDGEKSKS-RRKRIPPGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVET 303
            |...|..|.:|:.| :|||   ||....:...|.:|.:.|....:.:.|...|....|::|..:.
  Rat     7 GDLSEVRDTQKAPSGKRKR---GESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQD 68

  Fly   304 CRKGFTTAGGLRLHIDHAHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPC 368
            |.|.|.:...|:.|:        ..||                               |.:.:.|
  Rat    69 CTKAFVSKYKLQRHM--------ATHS-------------------------------PEKTHKC 94

  Fly   369 TECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIK-NYVCPYCGVGK 432
            ..|||:|.....||.|::.||..:..|.|..|||.:......|.||..||... :..|..|
  Rat    95 NYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVC---- 155

  Fly   433 TTRQEWNT------HILTH-------TQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQY 484
              .|.:.:      |:.:|       .:|||.:|..||...:.::.:..|: :||...|::.|||
  Rat   156 --LQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHM-VVHTGRKDFLCQY 217

  Fly   485 CGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMG 549
            |.:.||:    |.|                        ||:|:|....:.|..::|
  Rat   218 CAQRFGR----KDH------------------------LTRHMKKSHNQELLKVKT--------- 245

  Fly   550 ETPGEQFDNPPAPPVEGISIEPI---MSRNAADELLKV 584
                        .||:  .::|.   ||....||||.|
  Rat   246 ------------EPVD--FLDPFTCNMSVPIKDELLPV 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	0/18 (0%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		COG5048	394..729	CDD:227381	49/208 (24%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	4/25 (16%)
		C2H2 Zn finger	453..474	CDD:275368	4/20 (20%)
		C2H2 Zn finger	482..502	CDD:275368	8/19 (42%)
		C2H2 Zn finger	510..530	CDD:275368	4/19 (21%)
		C2H2 Zn finger	638..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	680..704	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		10/28 (36%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		22/87 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	4/19 (21%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		61/274 (22%)
		SFP1	<58..139	CDD:227516	26/119 (22%)
		C2H2 Zn finger	64..86	CDD:275368	6/29 (21%)
		zf-H2C2_2	79..103	CDD:404364	10/62 (16%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	4/25 (16%)
		C2H2 Zn finger	187..207	CDD:275368	4/20 (20%)
		C2H2 Zn finger	215..233	CDD:275368	11/45 (24%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		11/50 (22%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..400
		Massively activates transcription. /evidence=ECO:0000250	384..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100