DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10274 and znf-782

DIOPT Version :9

Sequence 1:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	643	Identity:	131/643 - (20%)
Similarity:	207/643 - (32%)	Gaps:	237/643 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 KEAEQVEKEVKQDELDAADLMTIFAAESSEESEEDIDQDVDFEPNSSDGDDDVPLAQRLRDNSRM 221
            |:.|:.|.|..:|||              .|.||:.|::::...||              |::..
Worm    22 KDPEEEEFEEYEDEL--------------LEEEEEFDEELEELENS--------------DSASS 58

  Fly   222 IPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSRRKRIP-------------PGERHLHRIIDCHI 273
            :..|.:          |.||...:.....|...:.:.|             |.:||:     |.:
Worm    59 LVSAGS----------PHGSSSSNGSHGSSPPLQVQSPSQGSGSSGSPTGQPEKRHI-----CTV 108

  Fly   274 CHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDHAHTELSEVHSCNVDGCGK 338
            |.:.|......|.|.:.|....|:.|  ..|:|.|.....|::| :..||. ...:.|..  |.|
Worm   109 CGKGFSYFSILESHKRSHTGEKPYNC--HFCQKTFAQKATLQVH-ERTHTG-ERPYKCRY--CEK 167

  Fly   339 TFPRIRLLTFHMKKMH-GITKAAAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGK 402
            ||.:....|.|.|..| ||       |:|.|.:|:|:...|.||..|...|..|  .|.|:.|.|
Worm   168 TFAQYGTKTVHEKSAHLGI-------RNYKCPKCDKLLSSPSALYTHKKTHGDK--TFRCDFCPK 223

  Fly   403 RFVINSALKDHL--MRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQS 465
            .|.:.:.||.|:  :.....:.:||.||..|.........|:.|||.|:.
Worm   224 TFALKNYLKLHVKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGERP--------------- 273

  Fly   466 LANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTH 530
                          |.|::|.|.|......:.||.|||||:...|:.|.:.|:....||.|..||
Worm   274 --------------YVCKFCPKAFASQGNLQSHERTHTGERPYSCQFCQRTFIQKSQLTAHESTH 324

  Fly   531 EKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKD 595
                      ..|:.                      |:.|               :|..
Worm   325 ----------LTQKH----------------------SVNP---------------DSTT----- 337

  Fly   596 PRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHE 660
                  .|:..:||:..:                                             |:
Worm   338 ------ADILPVAGSVTD---------------------------------------------HQ 351

  Fly   661 KVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETALKRHQ---RTHENRPPVI 722
            .|.::.|.||.|::..|.:|..|...||.:..:.|..||..:.|:.:|..||   ...:||....
Worm   352 MVGNYECTFCNKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQKISLNIHQDQCEAFKNRLKTT 416

  Fly   723 SPKF----------------------------YAAREELEEQERSKREAKRQADAKRR 752
            ..:|                            ..||.:|.:|:...:.:..::|.:.:
Worm   417 DSQFSHNCDGCGKSFVQRIALQIHVDSCEPHKNLARLKLSQQQNQNQNSDSESDTEMK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	7/18 (39%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		COG5048	394..729	CDD:227381	66/367 (18%)
		C2H2 Zn finger	397..417	CDD:275368	7/21 (33%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..474	CDD:275368	0/20 (0%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	0/20 (0%)
		C2H2 Zn finger	667..687	CDD:275368	7/19 (37%)
		zf-H2C2_2	680..704	CDD:290200	7/23 (30%)
		C2H2 Zn finger	695..715	CDD:275368	7/22 (32%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	5/19 (26%)
		zf-H2C2_2	119..143	CDD:290200	8/25 (32%)
		C2H2 Zn finger	134..154	CDD:275368	6/22 (27%)
		zf-H2C2_2	147..171	CDD:290200	9/27 (33%)
		C2H2 Zn finger	162..180	CDD:275368	7/19 (37%)
		COG5048	<187..404	CDD:227381	73/350 (21%)
		C2H2 Zn finger	191..211	CDD:275370	7/19 (37%)
		C2H2 Zn finger	218..239	CDD:275368	7/20 (35%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..285	CDD:290200	10/53 (19%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		zf-H2C2_2	288..313	CDD:290200	10/24 (42%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..403	CDD:275368	5/16 (31%)
		C2H2 Zn finger	424..441	CDD:275368	0/16 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000