Protein Alignment CG10274 and ZNF564

DIOPT Version :10

• Sequence 1: NP_001097525.1
• Gene: CG10274 / 38716
• FlyBaseID: FBgn0035690
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: NP_659413.1
• Gene: ZNF564 / 163050
• HGNCID: 31106
• Length: 553
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 146/554 - (26%)
• Similarity: 224/554 - (40%)
• Gaps: 131/554 - (23%)

  Fly   224 KAKAAVIKEEDQEFPTGSEEEDEDGEK-----SKSRRKRIPPGERHLHRIIDCHIC------HQK 277
            |.:..:::...:|..:.|:|.|:.||.     :.:..|:||.    :.|..:|.:|      |..
Human    57 KNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPT----IVRPCECSLCGKVFMHHSS 117

  Fly   278 FKKAIR---------YEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHIDHAHTELSEVHSC-- 331
            ..:.||         |:|:.:.     |::||  .|.|.|::....|.| :..||. .:.::|
Human   118 LSRHIRSHLGHKPYDYQEYGEK-----PYKCK--QCGKAFSSCQSFRRH-ERTHTG-EKPYACPE 173

  Fly   332 ------------------NVDG------CGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECE 372
                              ..||      |||.|.|..|...|.:...|       .:.|.|.||.
Human   174 CGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTG-------EKPYECQECA 231

  Fly   373 KVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQE 437
            |.|....:.::||.:|.| :.|:.|..|||.|...|..:.|...|.|.|.:.|..||....:...
Human   232 KAFISLPSFQRHMIRHTG-DGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTN 295

  Fly   438 WNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTH 502
            :.:|::.||.:..:||.:|..|......:..|.: .|...|.|.|..|||||..|...:.||.||
Human   296 FQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHER-THTGEKPYECNKCGKTFSSSSNVRTHERTH 359

  Fly   503 TGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETP------GEQFDNPPA 561
            ||||..|||.|||.|:...|:.:|:..|                 .|:.|      |..||.|
Human   360 TGEKPYECKECGKAFISLPSVRRHMIKH-----------------TGDGPYKCQVCGRAFDCP-- 405

  Fly   562 PPVEGISIEPIMSRNAADEL---LKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSW 623
                  |...|..|....|.   .:||.::..::       :|:....:..|.
Human   406 ------SSFQIHERTHTGEKPYECQVCGKAFISL-------KRIRKHMILHTG------------ 445

  Fly   624 SPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHT 688
                     :|.:.|..||:.|:...:::.|.: .|...|.:.|:.|.|.|..|.::|.||..||
Human   446 ---------DGPYKCQVCGKAFDCPSSVRTHER-THTGEKPYECKECGKAFNYASSIRIHERTHT 500

  Fly   689 GEKPFECKTCGTHFRQETALKRHQRTHENRPPVI 722
            ||||:|||.||..|...::.:||:|.|....|.:
Human   501 GEKPYECKQCGKTFSYSSSFQRHERAHNGDKPYV 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	9/24 (38%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		COG5048	394..729	CDD:227381	97/338 (29%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	4/20 (20%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	667..687	CDD:275368	8/19 (42%)
		C2H2 Zn finger	695..715	CDD:275368	8/19 (42%)
ZNF564	NP_659413.1	KRAB	3..44	CDD:460171
		C2H2 Zn finger	78..97	CDD:275368	4/18 (22%)
		COG5048	85..523	CDD:227381	134/513 (26%)
		C2H2 Zn finger	105..125	CDD:275368	5/19 (26%)
		C2H2 Zn finger	143..163	CDD:275368	7/22 (32%)
		C2H2 Zn finger	171..191	CDD:275368	1/19 (5%)
		C2H2 Zn finger	199..219	CDD:275368	7/19 (37%)
		C2H2 Zn finger	227..247	CDD:275368	7/19 (37%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	4/20 (20%)
		C2H2 Zn finger	339..359	CDD:275368	9/19 (47%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		C2H2 Zn finger	395..415	CDD:275368	7/27 (26%)
		C2H2 Zn finger	423..443	CDD:275368	3/26 (12%)
		C2H2 Zn finger	451..471	CDD:275368	5/20 (25%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)