DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10274 and ZNF280A

DIOPT Version :9

Sequence 1:NP_001097525.1 Gene:CG10274 / 38716 FlyBaseID:FBgn0035690 Length:863 Species:Drosophila melanogaster
Sequence 2:NP_542778.2 Gene:ZNF280A / 129025 HGNCID:18597 Length:542 Species:Homo sapiens


Alignment Length:352 Identity:69/352 - (19%)
Similarity:104/352 - (29%) Gaps:121/352 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 NSSDGDDDVPLAQRLRDNSRMIPKAKAAVIKEED-----QEFPTGSEEEDEDGEKSKSRRKRIPP 260
            |.:|.:.....|..:.|.|.:..:.|....|:|:     .:|..|  :...||:.          
Human   238 NLTDPERASESALAMTDISSLASQNKTFDPKKENPIVLLSDFYYG--QHKGDGQP---------- 290

  Fly   261 GERHLHRIIDCHICHQKFKKAIRYEEHMKHH-------NDLLPFQCKVETCRKGFTTAGGLRLHI 318
             |:..|....|..| .|..|.|::..|||||       ||........:.|.:.|.|...|:.||
Human   291 -EQKTHTTFKCLSC-VKVLKNIKFMNHMKHHLEFEKQRNDSWEDHTTCQHCHRQFPTPFQLQCHI 353

  Fly   319 DHAHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECEKVFRCPMALKK 383
            |..|..:.....|.:                                     ||..|.....|.:
Human   354 DSVHIAMGPSAVCKI-------------------------------------CELSFETDQVLLQ 381

  Fly   384 HMYKHDGK-ELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQ 447
            ||..|... |:|:.|.:|..|   :|...|                                   
Human   382 HMKDHHKPGEMPYVCQVCHYR---SSVFAD----------------------------------- 408

  Fly   448 EKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKV 512
                              :..|.:..||..||..|.:|.|.|..:.....|...|:..:..:|..
Human   409 ------------------VETHFRTCHENTKNLLCLFCLKLFKTAIPYMNHCWRHSRRRVLQCSK 455

  Fly   513 CGKKFLYPKSLTKHLKTHEKRVLRAIE 539
            |..:||..|...:| ||.:.:..:..|
Human   456 CRLQFLTLKEEIEH-KTKDHQTFKKPE 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10274NP_001097525.1 zf-AD 15..90 CDD:214871
C2H2 Zn finger 334..353 CDD:275368 0/18 (0%)
C2H2 Zn finger 368..388 CDD:275368 6/19 (32%)
COG5048 394..729 CDD:227381 26/146 (18%)
C2H2 Zn finger 397..417 CDD:275368 5/19 (26%)
C2H2 Zn finger 425..445 CDD:275368 0/19 (0%)
C2H2 Zn finger 453..474 CDD:275368 1/20 (5%)
C2H2 Zn finger 482..502 CDD:275368 5/19 (26%)
C2H2 Zn finger 510..530 CDD:275368 7/19 (37%)
C2H2 Zn finger 638..659 CDD:275368
C2H2 Zn finger 667..687 CDD:275368
zf-H2C2_2 680..704 CDD:290200
C2H2 Zn finger 695..715 CDD:275368
ZNF280ANP_542778.2 DUF4195 47..217 CDD:316361
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 105..185
C2H2 Zn finger 336..357 CDD:275368 7/20 (35%)
C2H2 Zn finger 366..386 CDD:275368 7/56 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10859
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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