Protein Alignment CG7376 and HLTF

DIOPT Version :10

• Sequence 1: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: XP_011511393.1
• Gene: HLTF / 6596
• HGNCID: 11099
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 1214
• Identity: 212/1214 - (17%)
• Similarity: 367/1214 - (30%)
• Gaps: 557/1214 - (45%)

  Fly   131 YDALYEKHRQ---TVHVEQERSLDLPKRFQSQLRKYQQRTVSWMLGREQQITQVP----ANFIVL 188
            :|.|:|..::   |..:|...:::.|      |..:|::.::||:.||......|    .|.:..
Human   214 FDKLFEDLKEDDKTHEMEPAEAIETP------LLPHQKQALAWMVSRENSKELPPFWEQRNDLYY 272

  Fly   189 HAIDGITRVFKHKYCLQFYPFEEEIPKISLPPGGILADEMGLGKTVEFLAMLLMN-----PRPQD 248
            :.|...:              |::.|:  ...||||||:||||||:..:|::|.|     |.|.:
Human   273 NTITNFS--------------EKDRPE--NVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIE 321

  Fly   249 SYRNDYWHQ--------------RLEEFSDEVPLKRSRISKKDEVFCICTKKHGKRVQCTKCRRW 299
            ..:.:...:              ...|.:|.:....||.|::..:..|..|...:..:.:..|..
Human   322 RVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPK 386

  Fly   300 QHEMCMTISEKSD--------LPH------------------------------LC------PSC 320
            :.:..:...|.||        ||.                              .|      |:.
Human   387 RRKTAVQYIESSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTT 451

  Fly   321 WSELVKSGERLVESG----------ATIIVSPNAIKMQWFEEIHKHISPSLKVLLYFGLHSTFWV 375
            ..:::|.|...||..          .|:|:.|.::...|.::..:||...        :|..|:|
Human   452 KKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSD--------VHLNFYV 508

  Fly   376 --------SPFDLAQYDVVLTDYTILRNEIYHTTDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCL 432
                    .|..|::.|:|||.|.||.:: |.|   |.|             |||..:.|.||.|
Human   509 YYGPDRIREPALLSKQDIVLTTYNILTHD-YGT---KGD-------------SPLHSIRWLRVIL 556

  Fly   433 DEAQMVESSTSAAAEMVRMLPAINRWAVTGT-----IDELPPLLEFVG-RPEVCRPPDAW-QTVD 490
            ||...:.:..:...:.|..|.:..||.:|||     :.:|..||.|:. :|.:.|  :.| :|:.
Human   557 DEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDR--EWWHRTIQ 619

  Fly   491 KAFQLNYK--CEPLLELLEH-SLWRTCKSKVEHE--LGIPPQTEVVHRLELSNVESLYYREEHLK 550
            :...:..:  ...|..|::: :|.||..||::.:  |.:|.:...:..:.||:.|...|:    .
Human   620 RPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQ----S 680

  Fly   551 CHEQFLAAVAKH------TRHNADNSSCLASISPQLLRIILKPFLRIRQTCSVPVVFNSNVSSTD 609
            ...:..|.:.::      ..|.||               :|...||:||.|
Human   681 VKNEGRATIGRYFNEGTVLAHYAD---------------VLGLLLRLRQIC-------------- 716

  Fly   610 YLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNI 674
                              |.|.|.|.|.|.||.:| :.:.||.|:.::
Human   717 ------------------CHTYLLTNAVSSNGPSA-FSLGNDTPEELR----------------- 745

  Fly   675 SVDSVLQIHAIYNLLQASSLAPAEHKLTELEHKKYQAQMSRLEWKYLEDNTRVLESALSSYNENL 739
                                            ||.               .|.::..|||.::
Human   746 --------------------------------KKL---------------IRKMKLILSSGSD-- 761

  Fly   740 EKVSELEKRFEGSTLDLLATMVNHKTSLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDI 804
                                                                             
Human   762 ----------------------------------------------------------------- 761

  Fly   805 WHNKLQNLKSTLIAEFEFLKGVMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVK 869
                                                        |...:|     ||:.....:.
Human   762 --------------------------------------------EECAIC-----LDSLTVPVIT 777

  Fly   870 PKKHRYCRLCLIRDSLNQFECLLFAKKLDEKATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWK 934
            ...|.:|:.|                       :.:.::|
Human   778 HCAHVFCKPC-----------------------ICQVIQN------------------------- 794

  Fly   935 EECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTDDPEEQSNYRILACQLDE 999
            |:..:|..|  |..|:.:                |.|..|        .|||.:.        |.
Human   795 EQPHAKCPL--CRNDIHE----------------DNLLEC--------PPEELAR--------DS 825

  Fly  1000 QLQFNQYNLQTSQLNFTRLCGRLKYLKHLKEDSADKPCPICQTQDDVRYVMMVCGHFVCQHCLDS 1064
            :.:.:.....:|::|                                          ...|.|..
Human   826 EKKSDMEWTSSSKIN------------------------------------------ALMHALTD 848

  Fly  1065 MRRKNGRAGVTKCPLCRQDSPQLYYSVRPGAHKSIIGDFSTKISSVVELVLKIKGENEQEKIIVF 1129
            :|:||                       |.....::..|:|.: |::|:.||..|       .||
Human   849 LRKKN-----------------------PNIKSLVVSQFTTFL-SLIEIPLKASG-------FVF 882

  Fly  1130 SQWQAILIEIARALSLNGIQFRNKCTNKDFDDFKN-PLSNVTCLLMPLSKGSKGLNLIEATHVFL 1193
            ::....:.:..|..|:       :|       |:| ...:.|.:|:.|..|..||||..|:.|||
Human   883 TRLDGSMAQKKRVESI-------QC-------FQNTEAGSPTIMLLSLKAGGVGLNLSAASRVFL 933

  Fly  1194 VEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSL 1237
            ::|..||..|.|...|.||.|||:...:.:|||.:::|||:|.:
Human   934 MDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKI 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	96/447 (21%)
		PHD_SF	281..320	CDD:473978	10/82 (12%)
		TPR	636..669	CDD:197478	8/32 (25%)
		RING_Ubox	1036..1082	CDD:473075	5/45 (11%)
		SF2_C_SNF	1104..1225	CDD:350180	36/121 (30%)
HLTF	XP_011511393.1	HIRAN	60..153	CDD:400928
		DEXHc_HLTF1_SMARC3	240..644	CDD:350829	96/446 (22%)
		DEAD-like_helicase_N	283..>357	CDD:475120	20/75 (27%)
		HepA	<472..990	CDD:440319	159/934 (17%)
		RING-HC_HLTF	759..813	CDD:438172	14/235 (6%)