Protein Alignment CG7376 and shprh

DIOPT Version :10

• Sequence 1: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: XP_003200358.1
• Gene: shprh / 560526
• ZFINID: ZDB-GENE-110512-2
• Length: 1644
• Species: Danio rerio
• Alignment Length: 1516
• Identity: 401/1516 - (26%)
• Similarity: 628/1516 - (41%)
• Gaps: 441/1516 - (29%)

  Fly    93 EQVLPLFFKDFRGSLEFEVAQQEKEH-KRPLKTYVTTKLYDALYEKHR-----QTVHVEQERSLD 151
            ::::.||: ||   :..||.:.|:|. ...|:.....:|||.:...|:     |:.||:....:.
Zfish   219 QKLMELFY-DF---IIPEVMENEEEACDTDLERQNVEELYDHVRHLHQTEAAEQSFHVQHPALIP 279

  Fly   152 LPKRFQSQLRKYQQRTVSWMLGREQ-QITQVPANFIVLHAI--DGIT----RVFKHKY--CLQFY 207
            :       ||.||.:.|:|||.||: :.:..|..  .||.:  :.:|    ::|.:.|  ||
Zfish   280 I-------LRPYQSQAVNWMLRREKYKSSSSPEQ--RLHFLWREMVTICGKKLFYNPYTGCL--- 332

  Fly   208 PFEEEIPKISLP-PGGILADEMGLGKTVEFLAMLLMN---------------------------- 243
              ..|.|...:. ||||||||||||||||.||::|.|
Zfish   333 --IREFPLAGVDWPGGILADEMGLGKTVEVLALILCNTRQNLEHGVLTLPVGRSVNYFVPPPPLE 395

  Fly   244 --------PRPQDS-----------------------------------YRNDYWHQR------- 258
                    |||::.                                   |:.|....|
Zfish   396 RQRIIKHEPRPKEKIIYPAVREMLLTAIKEMKVGKGASINAIFAYLRTMYKYDTLKNRNHIKKIL 460

  Fly   259 ----------------------------------------------------------------- 258
                                                                             
Zfish   461 TKLISENIVEQIKGRGLAGSFKLGKNYKEKKKKPVTARTKSADQPAPRRTSRRVSAPDKDSSLTS 525

  Fly   259 -------------------LEEF-SD-------EVPLKRSRI----------------------- 273
                               .||. ||       |.||::..:
Zfish   526 YTTTASDSASEDSMNPPLLTEELKSDPDSLLDPENPLQKKPVDITDDKEIPDKPQLQITEDVHIE 590

  Fly   274 --------SKKDEV------------------FCICTK----KHGKRVQCTKCRRWQHEMCMTIS 308
                    :.|.||                  .|||.:    .:..||||..|..|||..|:...
Zfish   591 SNKPDLMQTSKPEVETPTRASVVPFNTPDYRFECICGELGLVDYKPRVQCLNCLLWQHAECVNYK 655

  Fly   309 EKS--DLPHLCPSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHI-SPSLKVLLYFGLH 370
            |::  ..|..||.|...:..     |.:|||:|:||::|..||.:||::|| :.||:||:|.|:.
Zfish   656 EENLETTPFYCPHCLVAMTP-----VSTGATLIISPSSICHQWVDEINRHIHTSSLRVLVYQGVK 715

  Fly   371 STFWVSPFDLAQYDVVLTDYTILRNEIYHT----TDFKSDRQMRHQQRYMRPNSPLLMVNWWRVC 431
            ...::.|..||:.|||:|.|.:||.|:.:.    ::.|..|:.|:|:|||...|||:.|.|||||
Zfish   716 RHGFIQPHILAEQDVVITTYDVLRTELNYVDIPHSNSKDGRRFRNQKRYMAIPSPLVAVEWWRVC 780

  Fly   432 LDEAQMVESSTSAAAEMVRMLPAINRWAVTGT-----IDELPPLLEFVGRPEVCRPPDAWQTVDK 491
            ||||||||.:|:.||||...|.::|||.|:||     :::|..|:.|:|             ||.
Zfish   781 LDEAQMVECTTAKAAEMALRLTSVNRWCVSGTPVQRGLEDLYGLVLFLG-------------VDP 832

  Fly   492 AF------QLNYK------CEPLLELLEHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYY 544
            .:      ||.|:      ..||..::...|||:.|..|..::.||||||.:|.|..|.||..:|
Zfish   833 YWVKYWWDQLLYRPYRHGNTAPLYNVIGQLLWRSAKKDVIDQIQIPPQTEEIHWLNFSPVERHFY 897

  Fly   545 REEHLKCHEQFLAAVAKHTRHNADNSSCLASISPQLLRIILKPFLRIRQTCSVPVVFNSNV---- 605
            ..:|..|.:..|..:    |..:|.|..|.|:..:.:..||.|.||:||.|..|.......
Zfish   898 HRQHEVCSQDALVKL----RKISDWSLKLGSLDRRTVTTILYPLLRLRQACCHPQAVRGEFLPLQ 958

  Fly   606 SSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYN 670
            .||  :..::||..|:.....||:...|....:.||||.|:.|:::|..|.:.|..:|: ::|.:
Zfish   959 KST--MTMEELLKSLQKKCRVECEEAHRQLVCALNGLAGIHIIRSEFVDAAEMYREVLR-SSEEH 1020

  Fly   671 EQNISVDSVLQIHAIYNLLQASSLAPAEHK--LTELEHKKYQAQMSRLEWKYLEDNTRVLESALS 733
            :..:..||:.::||.:||::   |..|.|.  ...|.....:.:..:|:..|:..    :.|.:|
Zfish  1021 KARLKTDSLQRLHATHNLME---LLSANHPGIPPTLRDDSLKEEAEQLKQHYMAK----VNSEVS 1078

  Fly   734 SYNENLEKVSE--LEKRFEGST-----LDLLATMVNHKTSLHDAIWNKVRDDFFRQNISVERLEN 791
            ..::||:.|.:  .|:|.:.:.     ||::...:.:  |:.|.:.::::::.   ..|.::..|
Zfish  1079 EAHQNLQPVLQHIKEQRRKVNLRSPWWLDVIQQAMQY--SMDDDLVSRIQNEL---TCSYKQQAN 1138

  Fly   792 VNSMA-------GMLYFMDIWHNKLQNLKSTLIAEFEFLKGVMQQACEAIKTGVLLSMEIINFIE 849
            ..|||       |:.:.:....:.|...:.|:....:.|:|...|                ..||
Zfish  1139 KLSMADKFRDARGLQFLLSTQMDDLMKSQKTVQDAVKKLEGPPSQ----------------QVIE 1187

  Fly   850 NVTVCHLTDILDANKDKPVK-PKKHRYCRLCLIRDSLNQFECLLFAKKL---------------- 897
            ..|:|||         :||: |..:  |..|...:....:|..||:..:
Zfish  1188 EATLCHL---------RPVRLPLNN--CVFCKADELFTDYESKLFSHTVKGQTAIFEEMIEDEEG 1241

  Fly   898 ---DEKATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYWI 959
               |...|.:.||...|.....:|:|.:|.:.::..|...||..|.:||....:...|...:||:
Zfish  1242 LVDDRLPTTSRGLWAASETERALKAILSFAKVRRLESGLIEEGNSFMELFESWKKEYKLLHEYWM 1306

  Fly   960 EVEYMVKAFDELEMC--KMRILLTDDPE------------EQSNYRILACQLDEQLQFNQYNLQT 1010
            .:...|.|.|||.|.  ::|:.|.|:|:            ||:..::|          |...:..
Zfish  1307 SLRDHVSAIDELGMATERLRVRLPDEPKPKVLHIIEPHEVEQNRIKLL----------NDRAVAK 1361

  Fly  1011 SQLNFTRLCGRLKYLKHLKEDSADK--------PCPICQTQDDVRYVMMVCGHFVCQHCLDSMRR 1067
            |||.  :..|:..||.:| |.|.||        |||||.......:.::.|||..|..|:..:..
Zfish  1362 SQLQ--KKLGQFLYLTNL-EKSQDKSTGGLNPEPCPICARPLGQEWAVLTCGHCFCNECIAIIVE 1423

  Fly  1068 K---NGRAGVTKCPLCRQDSPQL---YYSVRPGAHKS----IIGDFSTKISSVVELVLKIKGENE 1122
            :   ..|....||.:|||.:...   |.......|:.    :.|..|||:.:||.::.|::..:.
Zfish  1424 QYSIGNRRRAIKCAICRQTTSHAEISYVFTTQNNHQGQDIPVKGSHSTKVEAVVRVLKKVQMTDP 1488

  Fly  1123 QEKIIVFSQWQAILIEIARALSLNGIQFRNKCTNKDFDDFKNPLS------NVTCLLMPLSKGSK 1181
            ..|.:|||.||.:|..||:||..|.::|   ........|:..||      .:..||:||..||.
Zfish  1489 GAKSLVFSTWQGVLDIIAKALFDNNMEF---AQINGIHKFQENLSAFKYEEKINILLLPLHTGSN 1550

  Fly  1182 GLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSLITSAD--DT 1244
            |||:||||||.||||||||..|.|||||:||.||.:||.||||::..||||.:.:::.:|:  .:
Zfish  1551 GLNIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTFVHRFLIKSTIEERMQAMLKTAEKSHS 1615

  Fly  1245 TTLSTHWDLENMTLDSLKKLF 1265
            :|...|.:....|:..|..||
Zfish  1616 STSMKHSEASVFTVADLADLF 1636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	153/609 (25%)
		PHD_SF	281..320	CDD:473978	16/44 (36%)
		TPR	636..669	CDD:197478	10/32 (31%)
		RING_Ubox	1036..1082	CDD:473075	14/48 (29%)
		SF2_C_SNF	1104..1225	CDD:350180	60/126 (48%)
shprh	XP_003200358.1	HepA	<198..>365	CDD:440319	54/163 (33%)
		DEAD-like_helicase_N	281..>401	CDD:475120	40/126 (32%)
		Linker_histone	412..481	CDD:459846	3/68 (4%)
		PHD_SHPRH	623..669	CDD:277022	16/45 (36%)
		DEXQc_SHPRH	<665..866	CDD:350828	83/218 (38%)
		MukB	<965..>1173	CDD:442330	48/220 (22%)
		RING-HC_SHPRH-like	1390..1443	CDD:438231	16/52 (31%)
		SF2_C_SNF	1469..1594	CDD:350180	60/127 (47%)