Protein Alignment CG7376 and CHD7

DIOPT Version :10

• Sequence 1: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Alignment Length: 1197
• Identity: 205/1197 - (17%)
• Similarity: 369/1197 - (30%)
• Gaps: 506/1197 - (42%)

  Fly    11 DEVPPESP-----EDP------TEFRYGKKRWV----FK-----------------DNLVEHKEE 43
            |:.||.||     |||      :..:..:||:.    ||                 .|..:.:::
Human   728 DKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQ 792

  Fly    44 ILI-----CIEKCQNARTRKLKFRSIRQESGSCILVLSHEQTHVRAREI-----------EMEVG 92
            ..:     .:||..::|:.|.     ::|||..:.:   |:.:|:.:..           ::|..
Human   793 ESVDAEGPVVEKIMSSRSVKK-----QKESGEEVEI---EEFYVKYKNFSYLHCQWASIEDLEKD 849

  Fly    93 EQVLPLF--FKDFRGSLEF--------------------EVAQQEKEHKRPLKTYVT-------- 127
            :::....  ||..:|..:|                    :.|:...:...|:..|:.
Human   850 KRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYE 914

  Fly   128 ------------TKL--YDALYEKHRQTVHVEQERSLDLPK-------RFQSQLRKYQQRTVSWM 171
                        .|:  ::.|..:..:|..||:..:.|..|       :..::||:||...|:|:
Human   915 DSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWL 979

  Fly   172 LGREQQITQVPANFIVLHAIDGITRVFKHKYCLQFYPFEEEIPKISLPPGGILADEMGLGKTVEF 236
            |          .|:            :..:.|                   |||||||||||::.
Human   980 L----------FNW------------YNMRNC-------------------ILADEMGLGKTIQS 1003

  Fly   237 LAMLLMNPRPQDSYRNDYWHQRLEEFSDEVPLKRSRISKKDEVFCICTKKHGKRVQCTKCRRWQH 301
            :..|.                       |:.||..                             |
Human  1004 ITFLY-----------------------EIYLKGI-----------------------------H 1016

  Fly   302 EMCMTISEKSDLPHLCPSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHISPSLKVLLY 366
            ...:.|:..|.:|:     |....::                     |.|         |.|::|
Human  1017 GPFLVIAPLSTIPN-----WEREFRT---------------------WTE---------LNVVVY 1046

  Fly   367 FG---------LHSTFWVSPFD------------LAQYDVVLTDYTILRNEIYHTTDFKSDRQMR 410
            .|         |:..::..|..            :..::::|||...|||
Human  1047 HGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRN--------------- 1096

  Fly   411 HQQRYMRPNSPLLMVNWWRVCLDEAQMVESSTSAAAEMVRMLPAINRWAVTG-----TIDELPPL 470
                          :.|..|.:|||..:::......|.::|:...::..:||     |::||..|
Human  1097 --------------IPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSL 1147

  Fly   471 LEFVGRPEVCRPPDAWQTVDKAFQLNY-------KCEPLLELLEHSLWRTCKSKVEHELGIPPQT 528
            |.|:   |..|.|.     :..|...:       :.:.|..:|:..:.|..|..||..|.  |:.
Human  1148 LHFL---EPSRFPS-----ETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLA--PKE 1202

  Fly   529 EVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNSSCLASISPQLLRIILKPFLRIRQ 593
            |.:..:||:|::..||| ..|:.:..||:......  |..|              :|...:.:|:
Human  1203 ETIIEVELTNIQKKYYR-AILEKNFTFLSKGGGQA--NVPN--------------LLNTMMELRK 1250

  Fly   594 TCSVPVVFNSNVSSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKY 658
            .|:.|.:.|.        ..:.:|...|..:..|
Human  1251 CCNHPYLING--------AEEKILEEFKETHNAE------------------------------- 1276

  Fly   659 YNLLLKLANEYNEQNISVDSVLQ--IHAIYNLLQASSLAPAEHKLTELEHK-KYQAQMSR----L 716
                            |.|..||  |.|...|:....|.|   ||....|: ...:||.|    |
Human  1277 ----------------SPDFQLQAMIQAAGKLVLIDKLLP---KLKAGGHRVLIFSQMVRCLDIL 1322

  Fly   717 EWKYLEDNTRVLESALSSYNENLEK--VSELEKRFEGSTLDLLATM-----VNHKTS----LHDA 770
            | .||.......|........||.:  :....|......:.||.|.     :|...:    :.|:
Human  1323 E-DYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDS 1386

  Fly   771 IWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTLIAEFEFLKGVMQQACEAIK 835
            .||...|  .:......|:....|:  .:|              .||....:.:.:..:|  ::|
Human  1387 DWNPQND--LQAQARCHRIGQSKSV--KIY--------------RLITRNSYEREMFDKA--SLK 1431

  Fly   836 TG----VLLSM----EIINFIENVTVCHLTDILDANKDKPVKPKKHRYCRLCLIRDSLNQFECLL 892
            .|    ||.||    ...|.::.::...:.|:|          :|..|..|....|..::| |
Human  1432 LGLDKAVLQSMSGRENATNGVQQLSKKEIEDLL----------RKGAYGALMDEEDEGSKF-C-- 1483

  Fly   893 FAKKLDE---KATVTEGLENPSMEISFIKSIFAFLRSKQDFS--------EWKEECQSKLELLSC 946
             .:.:|:   :.|.|..:|:.....:|.|:.|....::.|.|        :|.::.:..::.|:.
Human  1484 -EEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNG 1547

  Fly   947 LQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTDDPEEQSNYRIL-ACQLDEQLQFNQYNLQT 1010
            ..:||                             .|.|..:...|:. |.:.||.::|:.
Human  1548 RNNLV-----------------------------IDTPRVRKQTRLYSAVKEDELMEFSD----- 1578

  Fly  1011 SQLNFTRLCGRLKYLKHLKEDSADKPC 1037
                             |:.||.:|||
Human  1579 -----------------LESDSEEKPC 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	64/385 (17%)
		PHD_SF	281..320	CDD:473978	4/38 (11%)
		TPR	636..669	CDD:197478	0/32 (0%)
		RING_Ubox	1036..1082	CDD:473075	2/2 (100%)
		SF2_C_SNF	1104..1225	CDD:350180
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	11/72 (15%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	4/56 (7%)
		PLN03142	967..>1566	CDD:215601	158/904 (17%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800