Protein Alignment CG7376 and Mi-2

DIOPT Version :10

• Sequence 1: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 1489
• Identity: 259/1489 - (17%)
• Similarity: 453/1489 - (30%)
• Gaps: 579/1489 - (38%)

  Fly    11 DEVPPESPEDPTEFRYGKKRWVFK-------------------DNLVEHKEEILICIEKCQNART 56
            ||.....|||....:.||||...|                   .:.|:|.||:.. ....:..|.
  Fly    41 DEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEY-PSTSKRGRK 104

  Fly    57 RKLKFRSIRQESGSCILVLSHEQ--THVRAREIEMEVGEQVLPLF--FKDFRGSLEFEVAQQEKE 117
            ||.:.::.:::..:...:.|.|.  :......:|:|..|:.|...  :|.|            ..
  Fly   105 RKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAF------------MH 157

  Fly   118 HKRPL-----KTYVTTKLYDALYEKHRQ----TVHVEQE-------------RSL-----DLPKR 155
            |.||:     ......||...:..|.|:    ..|::||             ||:     :.|:.
  Fly   158 HVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRS 222

  Fly   156 FQSQLRKYQQRTVSWMLGREQQITQVPANFIVLHAIDGITRVFKHKYCLQFYPFEEEIPKISLPP 220
            .:|...:.........:..|::..:                             ||:.|:
  Fly   223 SRSSRNEKPDDIYEEAVEEEEEEEE-----------------------------EEKKPR----- 253

  Fly   221 GGILADEMGLGK-------TVEFLAMLLMNPRPQDS------------YRNDYWHQRLEEFSD-- 264
                ....|.||       .|..|.:.|:..|.:||            ..:|...:|:.:.||
  Fly   254 ----RKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDS 314

  Fly   265 ----EVPL----------------------------------KRSRISK------------KDEV 279
                |.|:                                  |::::.|            :.:.
  Fly   315 ADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQD 379

  Fly   280 FCICTKKHGKRVQCTKCRRWQHEMCM--TISEKSDLPHLCPSCWSELVKSGERLVESGATIIVSP 342
            :|...::.|:.:.|..|.|..|.:|:  .:.|..:....||.|.:          :.||.
  Fly   380 YCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEA----------DGGAA----- 429

  Fly   343 NAIKMQWFEEIHKHISPSLKVLLYFGLHSTFWVSPFDLAQYDVVLTDYTILRNEIYHTTDFKSDR 407
                                                                         :.:.
  Fly   430 -------------------------------------------------------------EEED 433

  Fly   408 QMRHQQRYMRPNSPLLMVNWWRVCLDEAQMV--ESSTSAAAEMVRMLPAINRWAVTGTIDELPPL 470
            ...||:             :.|||.|..:::  :|..|          |.:.:.:...:|.:|.
  Fly   434 DDEHQE-------------FCRVCKDGGELLCCDSCPS----------AYHTFCLNPPLDTIPD- 474

  Fly   471 LEFVGR---PEVCRPPDAWQTVDKAFQLNYKCEPLLELLEHSLWR-----------TCK------ 515
                |.   |....||           |..|.|.::      .||           |.|
  Fly   475 ----GDWRCPRCSCPP-----------LTGKAEKII------TWRWAQRSNDDGPSTSKGSKNSN 518

  Fly   516 SKVE------HELG------IPP-QTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTR--H 565
            |:|.      |.:.      :|. |.:|.|.|.:.:.:..|..||..|..|....|..::.|  .
  Fly   519 SRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQR 583

  Fly   566 NADNSSCLASISPQLL-----RIILKPFLRIRQTCSVPVVFNSNVS---STDYLHPQDLLARLKS 622
            :.|.....|:...::|     :..:||...|.|.     |.|...:   ||.||.....|...||
  Fly   584 HKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQR-----VINHRTARDGSTMYLVKWRELPYDKS 643

  Fly   623 NNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYN 687
            ..|.|        .....||.          |||.||..|..:......|:.|
  Fly   644 TWEEE--------GDDIQGLR----------QAIDYYQDLRAVCTSETTQSRS------------ 678

  Fly   688 LLQASSLAPAEHKLTELEHKKYQAQMSRLEWKYLEDNTRVLESALSSYNENLEK-VSELEKRFEG 751
                              .|..:.:.|:|:   :||:.   :..:..|....|| .::|:|::|
  Fly   679 ------------------KKSKKGRKSKLK---VEDDE---DRPVKHYTPPPEKPTTDLKKKYE- 718

  Fly   752 STLDLLATMVNHKTSLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTL 816
               |..|.:......||.                 .::|.:|      :....|...:    .|:
  Fly   719 ---DQPAFLEGTGMQLHP-----------------YQIEGIN------WLRYSWGQGI----DTI 753

  Fly   817 IAEFEFLKGVMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPKKHRYCR---- 877
            :|:               :.|:..:::.:.|:.::                   .|..:||
  Fly   754 LAD---------------EMGLGKTIQTVTFLYSL-------------------YKEGHCRGPFL 784

  Fly   878 ----LCLIRDSLNQFE-------CLLFAKKLDEKATVTEGLENPSMEISFIK-----SIFAFLRS 926
                |..:.:...:||       |:.:....|.:|.:.|.      |:||.:     |..:.||:
  Fly   785 VAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIREN------ELSFEEGAIRGSKVSRLRT 843

  Fly   927 KQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCK---------------- 975
                      .|.|..:|....:|:.........:::.|...||....|
  Fly   844 ----------TQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898

  Fly   976 MRILLTDDPEEQSNYRILACQLDEQLQF---NQYN-LQTSQLNFTRLCGRLKYLKHLKEDSADKP 1036
            .::|||..| .|:|..    :|...|.|   :::| ||..|..|..: .:.:.:|.|.|...  |
  Fly   899 YKLLLTGTP-LQNNLE----ELFHLLNFLSRDKFNDLQAFQGEFADV-SKEEQVKRLHEMLG--P 955

  Fly  1037 CPICQTQDDVRYVMMVCGHFVCQHCLDSMRRK-------------NGRAGVTKCPL--------- 1079
            ..:.:.:.||...|.....|:.:..|.:|::|             |.::|...|.|
  Fly   956 HMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKK 1020

  Fly  1080 -CRQDSPQLYYSVRPGAHKSIIGDFS----TKISSVVELVLK----IKGENEQEKIIVFSQWQAI 1135
             |  :.|.|:.|....|..:..|.:.    ||.:..:.|:.|    :|.:|  .::::|||...:
  Fly  1021 CC--NHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQN--HRVLIFSQMTKM 1081

  Fly  1136 LIEIARALSLNGIQFR---------NKCTNKDFDDFKNPLSNVTCLLMPLSKGSKGLNLIEATHV 1191
            | :|.... |.|.|::         .....:..|.|..|.:.....|:....|..|:||..|..|
  Fly  1082 L-DILEDF-LEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTV 1144

  Fly  1192 FLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSLITSADDTTTLSTH 1250
            .:.:...||.::.||..|.||.||.....::||:...::||.    :|.......:.||
  Fly  1145 IIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEER----VTQVAKRKMMLTH 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	54/441 (12%)
		PHD_SF	281..320	CDD:473978	10/40 (25%)
		TPR	636..669	CDD:197478	8/32 (25%)
		RING_Ubox	1036..1082	CDD:473075	13/68 (19%)
		SF2_C_SNF	1104..1225	CDD:350180	34/137 (25%)
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/64 (20%)
		TNG2	<282..422	CDD:227367	20/139 (14%)
		PHD1_CHD_II	380..422	CDD:277006	10/41 (24%)
		PHD2_CHD_II	440..482	CDD:277007	11/56 (20%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	15/75 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	21/76 (28%)
		PLN03142	720..>1234	CDD:215601	109/575 (19%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358