DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and CG4049

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_611885.3	Gene:	CG4049 / 37860	FlyBaseID:	FBgn0034976	Length:	1669	Species:	Drosophila melanogaster

Alignment Length:	1470	Identity:	263/1470 - (17%)
Similarity:	432/1470 - (29%)	Gaps:	651/1470 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGVVLCEIADEVPPESPE------DPTE---------------FRYGKKRWVFKDNLVE----H 40
            |:|.:      |||.:.||      .|.|               ..||.||   |::..|    :
  Fly   128 MEGTM------EVPVKMPEYCPETSQPVEPDRVINPLAEVAKNTVPYGHKR---KNSAGEDQAAN 183

  Fly    41 KEEILICIEKCQNARTRKLKFRSIRQESG--SCILVLSHEQTHVRA---------REIEME-VGE 93
            |:..:...|:.:|:..|| ..|.:..|:.  :..|....|::...|         |||:.: |.:
  Fly   184 KKLSMAAAEEKKNSHLRK-NIRDVMNENNLDTTTLAAQREESERLARVAGQQKSMREIQKQVVHK 247

  Fly    94 QVLPLFFKDFRGSLEFEVAQQEKEHKRPL---------KTYVTT--------KLYDALYE----K 137
            |:..:...|....:|........||..|:         .|:..:        .:.|.|::    :
  Fly   248 QIFRILQLDESEGIESCAVANPVEHHPPVDFPEEEIASDTFDDSNSSSLSGGSIEDVLHKGASVQ 312

  Fly   138 HRQTVHV------------EQERSLDLPKRFQSQLRKYQQRTVSWMLGREQQITQVP-------- 182
            ..:.|.:            |:|...|     ...|.:....|.|.|  ..:.|..||
  Fly   313 PSEVVTIDDSSDDDCILLSEEEEEED-----DEDLNESDDATNSGM--HVKDIYNVPDENGQVVV 370

  Fly   183 -----------------ANFIVLHAIDGITRVFKH------KYCLQFYPFEEEIPKISLPPGGIL 224
                             |..|..|.|.|:..::.:      :|            ..|...|.||
  Fly   371 NMAHPEGEETLYLAPQIAKVIKPHQIGGVRFLYDNIIESTRRY------------NKSSGFGCIL 423

  Fly   225 ADEMGLGKTVEFLAMLLMNPRPQDSYRNDYWHQRLEEFSDEVPLKRSRISKKDEVFCICTKKH-- 287
            |..||||||::.::                                         ||....:|
  Fly   424 AHSMGLGKTLQVVS-----------------------------------------FCDIFLRHTS 447

  Fly   288 GKRVQC----TKCRRWQHEMCMTISEKSDLPHLCPSCWSELVKSGERLVESGATIIVSPNAIKMQ 348
            .|.|.|    ...:.|..|..|.|...|...::.|..:...|.:.::
  Fly   448 AKTVLCVMPINTLQNWLSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQ------------------ 494

  Fly   349 WFEEIHKHISPSLKVLLYFGLHSTFWVSPFDLAQYD--VVLTDYTILR---NEIYHT-------- 400
                  |.::...||:|.       ||       :|  |:|..|.:.|   .::..|
  Fly   495 ------KTLTARAKVILN-------WV-------HDGGVLLIGYELFRLLALKLVKTRKRKGSVI 539

  Fly   401 ----TDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESSTSAAAEMVRMLPAINRWAVT 461
                .|..||......:..::|...|:      :| ||...:::|.:..:..::.:....|..:|
  Fly   540 RPDGMDSSSDLMNLVYEALVKPGPDLV------IC-DEGHRIKNSHAGISLALKEIRTRRRIVLT 597

  Fly   462 G------------TIDELPPLLEFVG-RPEVC----RPPDAWQTVDKAFQ----LNYKCEPLLEL 505
            |            .:|.:.|  .::| |.|.|    ||....|.||....    :.|:...|..|
  Fly   598 GYPLQNNLLEYWCMVDFVRP--NYLGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSL 660

  Fly   506 LEHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNS 570
            |...:.|  :|....:|.:|.:.|.|..::::..:.        |.::.|:..|
  Fly   661 LLGFVQR--RSHTVLQLTLPQKYEYVILVKMTAFQR--------KLYDTFMTDV----------- 704

  Fly   571 SCLASISPQLLRIILKPFLRIRQTCSVPVVFNSNVSSTDYLHPQDLLARLKSNNENECKTELRTW 635
                                                                         :||.
  Fly   705 -------------------------------------------------------------VRTK 708

  Fly   636 ASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYNLLQASSLAPAEHK 700
            |               ||..:|.:.:..|:   :|..::          :||.|
  Fly   709 A---------------FPNPLKAFAVCCKI---WNHPDV----------LYNFL----------- 734

  Fly   701 LTELEHKKYQAQMSRLEWKYLEDNTRVLESALS-----SYNENLEKVSELEKRFEGS-------- 752
                  ||.:..:.      ||.:..|.:.|.:     |.:.:|...|.|||:..||
  Fly   735 ------KKCETDLD------LEIDEEVTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIE 787

  Fly   753 --------TL-------DLLATMVNHKTSLHDAIWNKVRDDFFRQNISVERLENVN-----SMAG 797
                    ||       ||.|..:|...|.:|                 |:.|.:|     |...
  Fly   788 TFSKAENQTLFNIPASSDLNAKYLNKSPSFYD-----------------EKPEPLNYGSFGSEGK 835

  Fly   798 MLYFMDIWHNKLQNLKSTLIAE---FEFLKGV---MQQACEAIKTGVLLSMEIINFIENVTVCHL 856
            ..|:||          |:::.:   .|.:|..   |....|:| ||   |.||::
  Fly   836 NNYWMD----------SSILPKPGCVEVIKQTDTNMSSNFESI-TG---SSEIVD---------- 876

  Fly   857 TDILDANKDKPVKPKKHRYCRLCLIRDSLNQFECLLFAKKLDEKATVTEGLENPSMEISFIKSIF 921
               ||.|:.|.|:......|       |.||.:....|.|..|....  |.:| |..::..:...
  Fly   877 ---LDTNEIKTVETTIQAPC-------SNNQLDNGCNAGKPSEWNAA--GSKN-SSGVAAAEPFK 928

  Fly   922 AFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTDDPEE 986
            ..|:|||...|:  .|       |...||:|..:..                     |:::.|:.
  Fly   929 KLLKSKQRNEEF--SC-------SWAVDLMKNYVSG---------------------LISNSPKM 963

  Fly   987 QSNYRILACQLDEQLQFNQYNLQTSQ----LNFTRLCGRLKYLKHLKEDSADKPCPICQTQDDVR 1047
            :    |..|.|.|.|......|..||    ||...:     |||.                   .
  Fly   964 E----IFFCILKESLNLGDRILLFSQSLLTLNLLEV-----YLKS-------------------S 1000

  Fly  1048 YVMMVCGHFVCQHCLDSMRRKNGRAGVTKCPLCRQDSPQLYYSVRPGAHKSIIGDFSTKISSVVE 1112
            ||                                           ||:::     ..||.||...
  Fly  1001 YV-------------------------------------------PGSNQ-----LWTKNSSYFR 1017

  Fly  1113 LVLKIKGENEQEKIIVFSQWQAILIEIARALSLNGIQFRNKCTNKDFDDFKNPLSNVTCLLMPLS 1177
            |......: |:|:::                                ::| |..|||...|:...
  Fly  1018 LDGSTSSQ-ERERLV--------------------------------NEF-NANSNVKLFLISTR 1048

  Fly  1178 KGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENIL------- 1235
            .||.|:||..|..|.:.:...||..:.||:.||:|:||.:|..|:|.:::..:|:.|.
  Fly  1049 AGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQIKKQ 1113

  Fly  1236 ------------SLITSADDTTTLSTHWDLENMTLDSLKK 1263
                        ....|..|.|.|...:|.:..|::.:.|
  Fly  1114 GMSDRIVDECNPEAHLSMKDITNLCQDYDSDEDTVEEVNK 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600	71/423 (17%)
		PHD_SF	281..320	CDD:304600	11/44 (25%)
		TPR	636..669	CDD:197478	5/32 (16%)
		RING	1037..1083	CDD:238093	2/45 (4%)
		HepA	<1096..1238	CDD:223627	34/160 (21%)
		Helicase_C	1108..1214	CDD:278689	25/105 (24%)
CG4049	NP_611885.3	SNF2_N	394..730	CDD:278600	84/545 (15%)
		DEXDc	420..598	CDD:238005	45/263 (17%)
		HELICc	958..1093	CDD:238034	48/244 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930