DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and Iswi

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	1222	Identity:	211/1222 - (17%)
Similarity:	376/1222 - (30%)	Gaps:	479/1222 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EIADEVPPESPEDPTEFRYGKKRWVFKDNLVEHKEEILICIEKCQNARTRKLKFRSIRQESGSCI 72
            |..:|...|:..|......|:|...| ||.:|..             |:|:..|...:.|
  Fly    10 EATEENSNETTSDAATSSSGEKEAEF-DNKIEAD-------------RSRRFDFLLKQTE----- 55

  Fly    73 LVLSHEQTHVRAREIEMEVGEQVLPLFFKDFRGSLEFEVAQQEKEHKRPLKTYVTTKLYDALYEK 137
             :.:|..|:                            ......|...||.|.....|..|....:
  Fly    56 -IFTHFMTN----------------------------SAKSPTKPKGRPKKIKDKDKEKDVADHR 91

  Fly   138 HRQTVHVEQERSLDL----------------PKRFQS-QLRKYQQRTVSWMLGREQQITQVPANF 185
            ||:|   |||...:|                |...:| ::|.||.|.::||:...:
  Fly    92 HRKT---EQEEDEELLAEDSATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYE--------- 144

  Fly   186 IVLHAIDGITRVFKHKYCLQFYPFEEEIPKISLPPGGILADEMGLGKTVEFLAMLLMNPRPQDSY 250
                  :||                          .||||||||||||::.:::|        .|
  Fly   145 ------NGI--------------------------NGILADEMGLGKTLQTISLL--------GY 169

  Fly   251 RNDYWHQRLEEFSDEVPLKRSRISKKDEVFCICTKKHGKRVQCTKCRRWQHEMCMTISEKSDLPH 315
                                              .||.|.
  Fly   170 ----------------------------------LKHFKN------------------------- 175

  Fly   316 LCPSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHISPSLKVLLYFG---LHSTFWVSP 377
                             ::|..|::.|.:....|..|..|. .|||:.:...|   ..:||....
  Fly   176 -----------------QAGPHIVIVPKSTLQNWVNEFKKW-CPSLRAVCLIGDQDTRNTFIRDV 222

  Fly   378 FDLAQYDVVLTDYTILRNEIYHTTDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESST 442
            ....::||.:|.|                      :..:|..|.....||..:.:|||..:::..
  Fly   223 LMPGEWDVCVTSY----------------------EMCIREKSVFKKFNWRYLVIDEAHRIKNEK 265

  Fly   443 SAAAEMVRMLPAINRWAVTGT-----IDELPPLLEFVGRPEVCRPP---DAWQTVDKAFQLNYKC 499
            |..:|::|.....||..:|||     :.||..||.|: .|:|....   |.|...:.....:...
  Fly   266 SKLSEILREFKTANRLLITGTPLQNNLHELWALLNFL-LPDVFNSSEDFDEWFNTNTCLGDDALI 329

  Fly   500 EPLLELLEHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLK-------------- 550
            ..|..:|:..|.|..|::||..|  .|:.|:...:.||.::..:|.:..||
  Fly   330 TRLHAVLKPFLLRRLKAEVEKRL--KPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKM 392

  Fly   551 CHEQFLAAVAKHTRH---------------------NADNSSCLASISPQL----LRIILKPFLR 590
            ..:..|..:.|.|.|                     |:...:.|..:.|:|    .|:::  |.:
  Fly   393 RLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLI--FSQ 455

  Fly   591 IRQTCSVPVVFNSNVSSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKND---- 651
            :.:...:         ..||.|         ..|.|.|:.:.:|.....|.....:.:.|.
  Fly   456 MTRMLDI---------LEDYCH---------WRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFL 502

  Fly   652 FPQAIKYYNLLLKLA---------NEYNEQNISVDSVLQIHAI--------YNLLQASSLAPAEH 699
            |..:.:...|.:.||         :::|.| :.:.::.:.|.|        :.|:..|::   |.
  Fly   503 FMLSTRAGGLGINLATADVVIIYDSDWNPQ-MDLQAMDRAHRIGQKKQVRVFRLITESTV---EE 563

  Fly   700 KLTELEHKKYQAQMSRLEWKYLEDNTRVLESALSSYNENLEKV--------SELEKRFEGSTLDL 756
            |:.|....|.:.....::...|.||    .|...:.:|.|..:        |..|.......:|:
  Fly   564 KIVERAEVKLRLDKMVIQGGRLVDN----RSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDV 624

  Fly   757 LATMVNHKTSLHDAIWNKVRDDFFRQ----------NISVERLE--------NVNSMAGML---- 799
            :......||:...|..:.:.:...|.          ..||.:.|        .:|::...:
  Fly   625 ILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPK 689

  Fly   800 ------YFMDIWHNKLQNL------------KSTLIAEFEFLKGVMQQACEAIKTGVLLSMEIIN 846
                  |.:|.:..:...:            |..::.:|:|....:.:         ||..||..
  Fly   690 RERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFE---------LLDQEIYY 745

  Fly   847 FIENV--TVCHLTDI-LDANKDKPVKPKKHRYCRLCLIRDSLNQFECLLFAKKLDEKATVTEGLE 908
            |.:.|  .|...|:: .||.|   |:.::.|                     |:||...:||. |
  Fly   746 FRKTVGYKVPKNTELGSDATK---VQREEQR---------------------KIDEAEPLTEE-E 785

  Fly   909 NPSMEISFIKSIFAFLRSKQDFSEW---------------KEECQSKLELLSCLQDLVKFQIKYW 958
            ....|....:...|:  :|:||:::               .::.:.|..     ::::::...:|
  Fly   786 IQEKENLLSQGFTAW--TKRDFNQFIKANEKYGRDDIDNIAKDVEGKTP-----EEVIEYNAVFW 843

  Fly   959 ------IEVEYMV-----------------KAFDELEMCKMR-----ILLTDDPEEQSNY----- 990
                  .::|.::                 ||.|: :|.:.|     :.|.....:..||
  Fly   844 ERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQ-KMSRYRAPFHQLRLQYGNNKGKNYTEIED 907

  Fly   991 RILACQLDE--------------------QLQFNQYNLQTSQLNFTRLCGRL 1022
            |.|.|.|.:                    |.:|:.:....:.|...|.|..|
  Fly   908 RFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTL 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600	82/429 (19%)
		PHD_SF	281..320	CDD:304600	3/38 (8%)
		TPR	636..669	CDD:197478	6/45 (13%)
		RING	1037..1083	CDD:238093
		HepA	<1096..1238	CDD:223627
		Helicase_C	1108..1214	CDD:278689
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	11/84 (13%)
		SNF2_N	131..411	CDD:278600	83/430 (19%)
		DEXDc	148..287	CDD:238005	47/245 (19%)
		HELICc	422..553	CDD:238034	23/151 (15%)
		HAND	697..796	CDD:286232	24/132 (18%)
		SANT	797..838	CDD:197842	5/47 (11%)
		SANT	799..838	CDD:238096	5/45 (11%)
		SLIDE	853..965	CDD:286233	19/108 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930