DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and Etl1

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	897	Identity:	172/897 - (19%)
Similarity:	308/897 - (34%)	Gaps:	282/897 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 GIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNSSCLASISPQLLRIILKP 587
            |...||....:|||:..|.          .|:::||               |.|||....:.::.
  Fly    63 GNDSQTPKKTKLELTVKEK----------EERYMAA---------------AKISPHFDTMAIQE 102

  Fly   588 FLRIRQTCSVPVVFNSNVSSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDF 652
            .|. |....|       .:|..||...   .:.|.:|....|::|:..:   ||::...|..||.
  Fly   103 SLS-RTNWDV-------AASVRYLREN---CKPKGHNGPLAKSKLKPRS---NGISGGNFSDNDH 153

  Fly   653 -------PQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYNLLQASSLAPAEHKLTELEHKKYQ 710
                   ....:.|:      ::.::..:|.....|...::..:..:|       |.||:..|..
  Fly   154 SDDDDVKQSKDQVYD------SDDSDSEMSTKMTGQRKKVFQFMNEAS-------LIELQSVKTL 205

  Fly   711 AQMSRL---------EWKYLEDNTRVLESALSSYNENLEKVSELEKRFEGSTLDLLATMVNHKTS 766
            ::...|         :|              |...:.||.:     |..|..|:....::|.:.:
  Fly   206 SEKKALAIIDVRPFSDW--------------SDLRQKLESI-----RMSGDLLNYAQELINKQNT 251

  Fly   767 LHDAIWNKVRDDFFRQNISVERLEN-VNSMAGMLYFMDIWHNKLQNLKSTLIAEFEFLKGVMQQA 830
            : .||.:|.       |..|.|||. :::.||::....:..:.|| |....|....:|..:.:|.
  Fly   252 V-AAILSKC-------NNMVSRLEKAISNGAGIVEQPKLLSSGLQ-LADYQIIGLNWLTVMHKQE 307

  Fly   831 CEAI---KTGVLLSMEIINFI----EN--VTVCHLTDILDANKDKPVKPKKHRYCRLCLIRDSLN 886
            ...|   :.|:..::::|.|:    ||  ....||..:..:..|. .:.:..|:|
  Fly   308 MNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDN-WEAEISRWC---------- 361

  Fly   887 QFECLLFAKKLDEKATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLV 951
                         ...|.|.......|...::..||    |..|:.:.....:...:.|..::..
  Fly   362 -------------PELVVEKYHGSQDERRRMRGRFA----KDGFTGFDVLLTTYHIVGSTPEERK 409

  Fly   952 KFQIKYWIEVEYMVKAFDELEMCK----------------MRILLTDDPEEQSNYRI--LAC--- 995
            .|::   .:::|::  |||..|.|                ||||||..|.:.:...:  |.|
  Fly   410 MFRV---CKLDYVI--FDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVM 469

  Fly   996 -----------------------QLDEQLQFNQYNLQ-TSQLNFTRLCGRLK--YLKHL-KEDSA 1033
                                   ..||..||.:..:| ..::....:..|||  .||:| |:.|.
  Fly   470 PKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSL 534

  Fly  1034 DKPCP----------------------ICQTQDDVRYVMMVCGHFVCQHCL-------------- 1062
            .:..|                      :|.:.:.....:|:....:..|.|
  Fly   535 VEKVPMSSQQKIYYHELVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGF 599

  Fly  1063 -------DSMRRKNGR------AGVTKCPLCRQDSPQLYYSVRPGAHKSIIGDFSTKISSVVELV 1114
                   .|.::.|.:      |.::...:.:..:...:|.|:  ...::|.| |.|...:..|:
  Fly   600 SKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVK--IPDNLICD-SGKFLYLDTLL 661

  Fly  1115 LKIKGENEQEKIIVFSQWQAILIEIARALSLNGIQF------------RNKCTNKDFDDFKNPLS 1167
            .|:|.|.  .::::|||:..:|..:...|.:....|            ::..|:.:.||
  Fly   662 PKLKAEG--HRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDD------ 718

  Fly  1168 NVTCLLMPLSKGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEE 1232
            ::...|:....|..|:||..|....:.:...||.:::||..|.||.||:||..::|.|...||||
  Fly   719 SIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEE 783

  Fly  1233 NILSL----------ITSADD-------------TTTLSTHWDLENMTLDSL 1261
            .||..          |||.:.             ||.|....|.|....:||
  Fly   784 GILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600	17/77 (22%)
		PHD_SF	281..320	CDD:304600
		TPR	636..669	CDD:197478	6/39 (15%)
		RING	1037..1083	CDD:238093	8/94 (9%)
		HepA	<1096..1238	CDD:223627	42/163 (26%)
		Helicase_C	1108..1214	CDD:278689	26/117 (22%)
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	56/327 (17%)
		DEXDc	308..453	CDD:238005	32/177 (18%)
		Helicase_C	651..765	CDD:278689	28/121 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840