DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and Marcal1

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	124/669 - (18%)
Similarity:	230/669 - (34%)	Gaps:	222/669 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 NEYNEQNISVDS-------VLQIHAI-YNLLQASSLAPAEHKL---TELEHKKYQAQMSRLEWKY 720
            ||.|:..:|:.|       ||..::| .||...|:     |:.   |...|::.......:..|.
  Fly   123 NERNKPTLSLSSDKEKPVAVLLGNSITCNLYLIST-----HRFAAQTSGYHEQLVTVFKNMPTKC 182

  Fly   721 LEDNTRVLESALSSYNENLEKVSELEK--RFEG---STLDLLA-TMVNHKTSLHDAIWNKVRDDF 779
            .:..||:....||.|.......::|:.  ...|   ..|||.. ..|..:.|:..:|..|:.|..
  Fly   183 YDGQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQL 247

  Fly   780 --FRQN---ISVERLENV------------NSMAGMLYFMDIWHNKLQNLKSTLIAEFEFLKGVM 827
              |:|:   .::.:...:            .::|...||.|.|         .|:
  Fly   248 MPFQQDGVCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDW---------PLL---------- 293

  Fly   828 QQACEAIKTGVLLSMEIINFIENVTVCHLTDILDAN--------------------KDKPVKPK- 871
              .|....|....:..|::.:..|.: |...:|:.|                    :||.::.|
  Fly   294 --VCTTASTRDSWAKHIMDLLPKVPI-HYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKF 355

  Fly   872 -------KHRYCRLCLIRDSLNQFECLLFAKKLDEKA------TVTEGLENPSMEI--------- 914
                   .|      .:::|  :.:|...||:|.::|      :.|..|..| :|:
  Fly   356 GFIIFDESH------TLKNS--KAKCTTTAKRLTDQAKRVVLLSGTPALSRP-LELFTQLQMIDG 411

  Fly   915 ---SFIKSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKM 976
               :|::....:...||....|....||.||           ::|..:.::||      |...|:
  Fly   412 KFMNFMEFTTRYCDGKQSTFGWDANGQSNLE-----------ELKVILHLKYM------LRRTKV 459

  Fly   977 RILLTDDPE--EQSNYRILACQLDEQLQFNQYNLQTSQLNFTRLCGRLKYLKHLKE--DSADKPC 1037
            .:|    |:  |::...::   ||..|.:.  |.:|                  ||  |:.:|
  Fly   460 EVL----PQLAEKNRETVV---LDPALVWT--NAET------------------KETLDAFNK-- 495

  Fly  1038 PICQTQDDVRYVMMVCGHFVCQHCLDSMRRKNGRAGVTKCPLCRQDSPQLYYSVRPGAHKSIIGD 1102
                                      .::...|||         .:...|.:..|....|
  Fly   496 --------------------------ELKTAKGRA---------TEEILLRFYARTAEVK----- 520

  Fly  1103 FSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIARALS--------LNGIQFRNKCTNKDF 1159
             :..:.:.::.::|     ||:|.|:|:..:.::..|:..||        ::| |.|:...:...
  Fly   521 -TRAVCAYLKTLVK-----EQKKFIIFAHHRVMMDAISDFLSGLKVHYIRIDG-QTRSDHRSDSV 578

  Fly  1160 DDFKNPLSNVTCLLMPLSKGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKVHRF 1224
            |.|:.. |:....|:.|...:.|:.|..|..:...|...||....||..|.||.||.:|......
  Fly   579 DTFQKK-SSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYL 642

  Fly  1225 IVNETIEENILSLITSADD 1243
            |.:.|.::.|.:::.:..:
  Fly   643 IAHNTADDIIWNMLKNKQE 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600
		PHD_SF	281..320	CDD:304600
		TPR	636..669	CDD:197478	1/1 (100%)
		RING	1037..1083	CDD:238093	3/45 (7%)
		HepA	<1096..1238	CDD:223627	35/149 (23%)
		Helicase_C	1108..1214	CDD:278689	28/113 (25%)
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	9/54 (17%)
		DEXDc	239..420	CDD:214692	33/211 (16%)
		DEXDc	265..394	CDD:238005	23/158 (15%)
		Helicase_C	518..632	CDD:278689	29/126 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930