DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and Chd1

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	150/836 - (17%)
Similarity:	246/836 - (29%)	Gaps:	349/836 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 EHSLWR-----------TCKSKVEHEL-------------GIPPQ--TEVVHRLELSNVESLYYR 545
            |.:.||           .|:.:::|||             |..|.  ||..    |...:||.|.
  Fly   425 EQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEY----LCKWQSLPYA 485

  Fly   546 E-----------EHLKCHEQFLAAVAKHTRHNADNSSCLASISPQLLRIILKPFLRIRQTCSVPV 599
            |           :..:|.|||         ::.::|.|..|...::::...| |.||:   :.|.
  Fly   486 ESTWEDAALVLRKWQRCAEQF---------NDRESSKCTPSRHCRVIKYRPK-FSRIK---NQPE 537

  Fly   600 VFNSNVSSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLK 664
            ..:|.::..||  ..|.|..|           |.:|....:.:.|.........|.|.:
  Fly   538 FLSSGLTLRDY--QMDGLNWL-----------LHSWCKENSVILADEMGLGKTIQTICF------ 583

  Fly   665 LANEYNEQNISVDSVLQIHAIYN----LLQASSL----------APAEHKLTELEHKKYQAQMSR 715
                       :.|:.:||.:|.    ::..|::          ||..:.:|.|...|.:..:.:
  Fly   584 -----------LYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQ 637

  Fly   716 LEWKYLEDNTRVLESALSSYNENLEKVSELEKRFEGSTLDLLATMVN--HKTSLHDAIWNKVRDD 778
            .||::...........|::|...|:     :|:|.| ||...|.:|:  |:....|::..|...:
  Fly   638 YEWQFESSKRLKFNCILTTYEIVLK-----DKQFLG-TLQWAALLVDEAHRLKNDDSLLYKSLKE 696

  Fly   779 F---FRQNISVERLEN-VNSMAGMLYFM-----DIWHNKLQNLKSTLIAEFEFLKGVMQQACEAI 834
            |   .|..|:...|:| :..:..:|:|:     |.|.|            ||...|
  Fly   697 FDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWEN------------FEVQHG--------- 740

  Fly   835 KTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPKKHRYCRLCLIRDSLNQFECLLFAKKLDE 899
                                        |.:.....:.|:.....::|......|     |.|..
  Fly   741 ----------------------------NAEDKGYTRLHQQLEPYILRRVKKDVE-----KSLPA 772

  Fly   900 KATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYM 964
            |......:|..|::..:.|                                       ||    :
  Fly   773 KVEQILRVEMTSLQKQYYK---------------------------------------WI----L 794

  Fly   965 VKAFD------------------ELEMCKMRILLTDDPEEQSNYRILACQLDEQLQFNQYNLQTS 1011
            .|.||                  ||:.|.....|.    ..|.:.::..|.||.||
  Fly   795 TKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALI----RPSEFELMGLQQDEALQ--------- 846

  Fly  1012 QLNFTRLCGRLKYLKHLKEDSADKPCPICQTQDDVRYVMMVCGHFVCQHCLDSMRRKNGRAGVTK 1076
                |.|.|..|.:                                   .||.:
  Fly   847 ----TLLKGSGKLV-----------------------------------LLDKL----------- 861

  Fly  1077 CPLCRQDSPQLYYSVRPGAHKSIIGDFSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIAR 1141
              |||                                 ||..|    .::::|||...:|..:|.
  Fly   862 --LCR---------------------------------LKETG----HRVLIFSQMVRMLDVLAD 887

  Fly  1142 ALSLNGIQF-------RNKCTNKDFDDFKNPLSNVTCLLMPLSKGSKGLNLIEATHVFLVEPILN 1199
            .|......|       :.:...:..|.|....|...|.|:....|..|:||..|..|.:.:...|
  Fly   888 YLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWN 952

  Fly  1200 PGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILS----------LITSADDTT 1245
            |.::.||..|.||.|||....::|.:...::||.|:.          |:....|||
  Fly   953 PQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTT 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600	28/130 (22%)
		PHD_SF	281..320	CDD:304600
		TPR	636..669	CDD:197478	3/32 (9%)
		RING	1037..1083	CDD:238093	5/45 (11%)
		HepA	<1096..1238	CDD:223627	35/158 (22%)
		Helicase_C	1108..1214	CDD:278689	28/112 (25%)
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991
		Chromo	458..509	CDD:278797	13/63 (21%)
		SNF2_N	548..829	CDD:278600	65/413 (16%)
		DEXDc	564..709	CDD:238005	31/167 (19%)
		Helicase_C	852..967	CDD:278689	34/199 (17%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840