DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7376 and Shprh

DIOPT Version :9

Sequence 1:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_001100940.1	Gene:	Shprh / 308282	RGDID:	1310342	Length:	1701	Species:	Rattus norvegicus

Alignment Length:	1678	Identity:	418/1678 - (24%)
Similarity:	672/1678 - (40%)	Gaps:	537/1678 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KDNLVEHKEEILICIEKCQNARTRKLKFRSIRQESGSCILVLSHEQTHVRAREIEMEVGEQVL-- 96
            :::||||..|           ||    |..:..||.|.:|:..|.:    ...:|.|  |.||
  Rat   117 EESLVEHFSE-----------RT----FTLMSSESSSQLLIYVHSE----CNNVEKE--ENVLKG 160

  Fly    97 --PLFFKDFRGSLEF------EVAQQEKE-----HKRPLKTY----------------------- 125
              .::.|..|....|      ::|..:|.     ::||..|:
  Rat   161 PASIYGKGIRVESSFSSDMLQDLAWLQKRRGIKLYQRPEGTHTIKVRIYLLEAGLTRLDFMSDAG 225

  Fly   126 ------------VTTKLY------------------------DALYEKHRQTVHVEQERSLDLPK 154
                        |..|||                        |.||:..::| |.::.:|:.:..
  Rat   226 SRMKKFNQLLKRVMGKLYSLSIPDVLEEDEEESESEPEGQDIDELYQFVKRT-HQQEAKSVQVDV 289

  Fly   155 RFQS---QLRKYQQRTVSWMLGREQQITQVPANFIVLHAI-------DGITRVFKHKY--CLQFY 207
            :..:   .||.||:..|:||| :::|....||: ..||.:       ||: .::.:.|  |: ..
  Rat   290 QHPALIPVLRPYQREAVNWML-QQEQFRSTPAD-NSLHFLWREIVTPDGL-NLYYNPYTGCI-IR 350

  Fly   208 PFEEEIPKISLPPGGILADEMGLGKTVEFLAMLLMNPR--------------------------- 245
            .|....|::.   |||||||||||||||.||::|.:.|
  Rat   351 DFPHAGPQLL---GGILADEMGLGKTVEVLALILTHTRQDVRQDALTLPEGKVVNYFIPTHCPRG 412

  Fly   246 -------------PQD------------------------------------------------- 248
                         |::
  Rat   413 KVKSREIQNTECEPKEKVHCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSTFRYDVQRNRSLLK 477

  Fly   249 ----------------------------SYRNDYWH----------QRLE--------------- 260
                                        :|:.|.:.          |::|
  Rat   478 RMLKCLIFEGLVKQIKGRGFSGTFTLGKNYKEDVFDKTKKQAVGSPQKIEKELRKSVNKDTDSEY 542

  Fly   261 -------------EFSDEVP------LKRSRISKKDEVF-------------------------- 280
                         :..|:.|      .::||..||..|.
  Rat   543 MPSDIYDDDNDNDDDDDDDPYYYYCKARKSRKLKKKPVLLTKKEKGQPVNLDSQVEAPAAGDCAS 607

  Fly   281 ---------------------------------------------------CICTK--KHGK--R 290
                                                               |||.:  :.|:  |
  Rat   608 ADAHVSESTCVSENRQIQDAEDCVESPSPAAMELAQSNTASFCETPDYRFECICGEFDQIGRKPR 672

  Fly   291 VQCTKCRRWQHEMCMTISEKS--DLPHLCPSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEI 353
            |||.||..|||..|:...||:  ..|..||.|...:     ..|.:.||:|:||::|..||.:||
  Rat   673 VQCLKCHLWQHAKCVNYEEKNLKVKPFYCPHCLVAM-----EPVSTRATLIISPSSICHQWVDEI 732

  Fly   354 HKHI-SPSLKVLLYFGLHSTFWVSPFDLAQYDVVLTDYTILRNEIYHT----TDFKSDRQMRHQQ 413
            ::|: |.||:||:|.|:....::.|..||:.|:|:..|.:||:|:.:.    ::.:..|::|:|:
  Rat   733 NRHVRSSSLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELNYVDIPHSNSEDGRRLRNQK 797

  Fly   414 RYMRPNSPLLMVNWWRVCLDEAQMVESSTSAAAEMVRMLPAINRWAVTGT-----IDELPPLLEF 473
            |||...|||:.|.|||:|||||||||..|..||||.:.|..||||.|:||     :::|..|:.|
  Rat   798 RYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCVSGTPVQRGLEDLFGLVVF 862

  Fly   474 VGRPEVCRPPDAWQTVDKAFQLNY----KCEP--LLELLEHSLWRTCKSKVEHELGIPPQTEVVH 532
            :|....|  ...|.     .:|.|    |..|  |...:...:||:.|..|..::.||||||.:|
  Rat   863 LGIEPYC--VKHWW-----IRLLYHPYCKKNPQHLYSFIAKIMWRSAKKDVIDQIQIPPQTEEMH 920

  Fly   533 RLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNSSCLASISPQLLRIILKPFLRIRQTCSV 597
            .|..|.||..:|..:|..|.:.   ||.| .|..:|.:..|:|:..:.:..||.|.||:||.|..
  Rat   921 WLHFSPVERHFYHRQHEVCCQD---AVVK-LRKISDWALKLSSLDRRTVSSILYPLLRLRQACCH 981

  Fly   598 PVVFNSNV----SSTDYLHPQDLLARLKSNNENECKTELRTWASSYNGLAAIYFIK--------- 649
            |.......    .||  :..::||..|:.....||:...|....:.||||.|:.||
  Rat   982 PQAVRGEFLPLQKST--MTMEELLTSLQKKCGTECEEAHRQLVCALNGLAGIHIIKGRRAQYRAA 1044

  Fly   650 -----------NDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYNLLQASSLAPAEHK--L 701
                       :::..|.:.|..:|: ::|.::..:..||:.::||.:||::   |..|:|.  .
  Rat  1045 LALPPPECVILSEYALAAELYREVLR-SSEEHKGKLKTDSLQRLHATHNLME---LLVAKHPGIP 1105

  Fly   702 TELEHKKYQAQMSRLEWKYLED-NTRVLES--ALSSYNENLEKVSELEKRFEGST---LDLLATM 760
            ..|...:.:.:..:|...|:.. ||.|.|:  ||....::   :.||:::....:   |:::...
  Rat  1106 PTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALQPVQQS---IRELQRKVHSGSPWWLNVVHRA 1167

  Fly   761 VNHKT--SLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTLIAEFEFL 823
            :.:..  .|...:.|::..::..|...:...|......|           ||.|.:|.:.|....
  Rat  1168 MEYAVDEELVQRVRNEISSNYKHQTDKLSMSEKFRDCRG-----------LQFLLTTQMEELHKF 1221

  Fly   824 KGVMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPKKHRYCRLCLIRDSLNQF 888
            :.::::|.:.::...  |.::   ||:.|||||         :|.:...: .|..|...:...::
  Rat  1222 QKLVREAVKKLEKPP--SRDV---IESATVCHL---------RPARLPLN-CCVFCKADELFTEY 1271

  Fly   889 ECLLFAKKL-------------------DEKATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWK 934
            |..||:..:                   |...|.|.||...|.....:|:|.:|.||.:...|:.
  Rat  1272 ESKLFSNTVKGQTAIFEEMIEDEEGLVDDRVPTTTRGLWAVSETERSMKAILSFARSHRFDVEYI 1336

  Fly   935 EECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTDDPEEQSN---YRILACQ 996
            :|....::|....:...|...:||:.:...|.|.|||.|...|:.:....|.:.|   :.|:...
  Rat  1337 DEGSVSMDLFEAWKKEYKLLHEYWMTLRNRVSAVDELAMATERLRVRHPKEPKPNPPVHHIIEPH 1401

  Fly   997 LDEQLQFNQYN---LQTSQLNFTRLCGRLKYLKHLKEDSADK--------PCPICQTQDDVRYVM 1050
            ..||.:....|   :.||||.  :..|:|.||.:| |.|.||        |||||..|...::.:
  Rat  1402 EVEQNRIKLVNDKAVATSQLQ--KKLGQLLYLTNL-EKSQDKTSGGINPEPCPICARQLGKQWAV 1463

  Fly  1051 MVCGHFVCQHC----LDSMRRKNGRAGVTKCPLCRQDSPQLYYSVRPGAHKSII----------- 1100
            :.|||..|..|    ::.....:.|:.: ||.:|||.:          :||.:.
  Rat  1464 LTCGHCFCNECTSIIIEQYSVGSHRSSI-KCAICRQTT----------SHKEVSYVFTSEKANQE 1517

  Fly  1101 ------GDFSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIARALSLNGIQF----RNKCT 1155
                  |..|||:.:||..::||:.::...|.:|||.||.:|..|::||:.|.:.|    |.|..
  Rat  1518 DDIPVKGSHSTKVEAVVRTLMKIQLKDPGAKALVFSTWQDVLDIISKALTDNNMGFTQISRIKTF 1582

  Fly  1156 NKDFDDFK-NPLSNVTCLLMPLSKGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPT 1219
            .::...|| :|..|:  ||:||..||.||.:||||||.||||||||..|.|||||:||.||.:||
  Rat  1583 QENLSAFKYDPQINI--LLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPT 1645

  Fly  1220 KVHRFIVNETIEENILSLITSADDTTTLST--HWDLENMTLDSLKKLFILKEE 1270
            .||||::..||||.:.:::.:|:.:.|.|:  |.:...:|:..|..||..:.|
  Rat  1646 IVHRFLIKATIEERMQAMLKTAERSHTSSSGKHSEASALTVADLADLFTKESE 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600	159/639 (25%)
		PHD_SF	281..320	CDD:304600	19/44 (43%)
		TPR	636..669	CDD:197478	10/52 (19%)
		RING	1037..1083	CDD:238093	15/49 (31%)
		HepA	<1096..1238	CDD:223627	70/163 (43%)
		Helicase_C	1108..1214	CDD:278689	52/110 (47%)
Shprh	NP_001100940.1	Linker_histone	433..504	CDD:278939	0/70 (0%)
		PHD_SHPRH	658..704	CDD:277022	19/45 (42%)
		SNF2_N	714..985	CDD:278600	107/281 (38%)
		HepA	<1341..1696	CDD:223627	125/370 (34%)
		RING	1450..1500	CDD:238093	16/50 (32%)
		Helicase_C	1531..1640	CDD:278689	52/110 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2149
eggNOG	1	0.900	-	-		E2759_KOG0298
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6489
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1568
OMA	1	1.010	-	-		QHG49298
OrthoDB	1	1.010	-	-		D110877at33208
OrthoFinder	1	1.000	-	-		FOG0004218
OrthoInspector	1	1.000	-	-		oto97998
orthoMCL	1	0.900	-	-		OOG6_104134
Panther	1	1.100	-	-	LDO	PTHR45865
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2964
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840