DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7376 and Shprh

DIOPT Version :9

Sequence 1:NP_001261471.1 Gene:CG7376 / 38715 FlyBaseID:FBgn0035689 Length:1270 Species:Drosophila melanogaster
Sequence 2:NP_001071175.1 Gene:Shprh / 268281 MGIID:1917581 Length:1674 Species:Mus musculus


Alignment Length:1695 Identity:429/1695 - (25%)
Similarity:687/1695 - (40%) Gaps:506/1695 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 CEIADEVPPES------------------PEDPTE-----------FRYGKKRWVF--------- 33
            |.|.||.||||                  .|:.|.           :|.......|         
Mouse    52 CIIIDEGPPESALHRDKKRRSETVSVLEATEEETRLSVTLNVTVSPYRVDNSWKAFLGDFALQLL 116

  Fly    34 -KDNLVEH-------------KEEILICI-EKCQNARTRK--------LKFRSIRQESGSCILVL 75
             |::||||             ..:.||.: .:|:|...::        :..:.||.||.....:|
Mouse   117 PKESLVEHFSERTFTLSPSESSSQFLIYVHSECKNVEKQENVLEGSAGVCSKGIRVESSFSSDML 181

  Fly    76 SHEQTHVRAREIEM----------EVGEQVLP-----LFFKDFRGSLEFEVAQQEKEHKRPLKTY 125
            .......:.|.|::          :||..:|.     |.|....||...:..|..|.....|..:
Mouse   182 QDLAWLQKRRGIKLYQRPDGTHTIKVGIYILEAGLTRLDFMSDAGSRMKKFNQLMKRVMEKLHNF 246

  Fly   126 VTTKL----------------YDALYEKHRQTVHVEQERSLDLPKRFQS---QLRKYQQRTVSWM 171
            :...:                .|.||...:|| |.::.||:.:..:..:   .||.||:..|:||
Mouse   247 IIPDVLEEEEEGSESEPEGQDIDELYHFVKQT-HQQETRSVQVDVQHPALIPVLRPYQREAVNWM 310

  Fly   172 LGREQQITQVPANFIVLHAI-------DGITRVFKHKY--CLQFYPFEEEIPKISLPPGGILADE 227
            |.:||..:..||: ..||.:       ||: :::.:.|  |: ...|....|::.   |||||||
Mouse   311 LQQEQFRSAPPAD-NSLHFLWREIVTPDGL-KLYYNPYTGCI-IRDFPHAGPQLL---GGILADE 369

  Fly   228 MGLGKTVEFLAMLLMNPR------------------------PQDSYRN----DYWHQRLEE--- 261
            ||||||||.||::|.:.|                        |::..:|    |..::..|:   
Mouse   370 MGLGKTVEVLALILTHTRQDVKQDALTLPEGKVVNYFIPTHCPREKVKNREIQDTEYEPKEKVHC 434

  Fly   262 --------------------------------FSDEVPLKRSRISK------------------- 275
                                            |..:|...|..:.:                   
Mouse   435 PPTRVMILTAVKEMNGKKGVSILSIYKYVSSIFRYDVQRNRGLLKRMLKCLIFEGLVKQIKGHGF 499

  Fly   276 ----------KDEVF-------------------------------------------------- 280
                      |::||                                                  
Mouse   500 SGTFTLGKNYKEDVFDKTKKQAVGSPRKIEKELRKSVNKDADSEYLPSNTSDDDEPYYYYCKAGK 564

  Fly   281 ----------------------------------------------------------------- 280
                                                                             
Mouse   565 SRSKLKKPALLTKKGKGQSVHLDSQGDAPAAGVCASTDVHVSENTCVSEDKQTQEAKDCAESPNP 629

  Fly   281 ----------------------CICTK----KHGKRVQCTKCRRWQHEMCMTISEKS--DLPHLC 317
                                  |||.:    .|..||||.||..|||..|:...||:  ..|..|
Mouse   630 AAEELAQSNTSSPCETSDYRFECICGEFDQIGHKPRVQCLKCHLWQHAKCVNYEEKNLKVKPFYC 694

  Fly   318 PSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHI-SPSLKVLLYFGLHSTFWVSPFDLA 381
            |.|...:     ..|.:.||:|:||::|..||.:||::|: |.||:||:|.|:....::.|..||
Mouse   695 PHCLVAM-----EPVSTRATLIISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKHGFLQPHFLA 754

  Fly   382 QYDVVLTDYTILRNEIYHT----TDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESST 442
            :.|:|:..|.:||:|:.:.    ::.:..|::|:|:|||...|||:.|.|||:|||||||||..|
Mouse   755 EQDIVIITYDVLRSELNYVNIPHSNSEDGRRLRNQKRYMAIPSPLVAVEWWRICLDEAQMVECPT 819

  Fly   443 SAAAEMVRMLPAINRWAVTGT-----IDELPPLLEFVGRPEVCRPPDAWQTVDKAFQLNY----K 498
            ..||||.:.|..||||.::||     :::|..|:.|:|....|  ...|.     .:|.|    |
Mouse   820 VKAAEMAQRLSGINRWCISGTPVQRGLEDLFGLVVFLGIEPYC--VKHWW-----IRLLYHPYCK 877

  Fly   499 CEP--LLELLEHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAK 561
            ..|  |...:...:||:.|..|..::.||||||.:|.|..|.||..:|..:|..|.:.   |:.|
Mouse   878 KNPQHLYSFIAKIMWRSAKKDVIDQIQIPPQTEEMHWLHFSPVERHFYHRQHEVCCQD---AIVK 939

  Fly   562 HTRHNADNSSCLASISPQLLRIILKPFLRIRQTCSVPVVFNSNV----SSTDYLHPQDLLARLKS 622
             .|..:|.:..|:|:..:.:..||.|.||:||.|..|.......    .||  :..::||..|:.
Mouse   940 -LRKISDWALKLSSLDRRTVSSILYPLLRLRQACCHPQAVRGEFLPLQKST--MTMEELLTSLQK 1001

  Fly   623 NNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYN 687
            ....||:...|....:.||||.|:.||.::..|.:.|..:|: ::|.::..:..||:.::||.:|
Mouse  1002 KCGTECEEAHRQLVCALNGLAGIHIIKGEYALAAELYREVLR-SSEEHKGKLKTDSLQRLHATHN 1065

  Fly   688 LLQASSLAPAEHK--LTELEHKKYQAQMSRLEWKYLED-NTRVLES--ALSSYNENLEKVSELEK 747
            |::   |..|:|.  ...|...:.:.:..:|...|:.. ||.|.|:  ||....::   :.||::
Mouse  1066 LME---LLGAKHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALQPVQQS---IRELQR 1124

  Fly   748 RFEGST---LDLLATMVNHKT---SLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWH 806
            :...::   |:::     |:.   |:.:.:..:||::     ||....:..:.::....|.|.  
Mouse  1125 KIHSNSPWWLNVI-----HRAMEFSVDEELVQRVRNE-----ISSNYKQQTDKLSMSEKFRDC-- 1177

  Fly   807 NKLQNLKSTLIAEFEFLKGVMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPK 871
            ..||.|.:|.:.|....:.::::|.:.::...  |.|:   ||:.|||||         :|.:..
Mouse  1178 RGLQFLLTTQMEELHKFQKLVREAVKKLEKPP--SREV---IESATVCHL---------RPARLP 1228

  Fly   872 KHRYCRLCLIRDSLNQFECLLFAKKL-------------------DEKATVTEGLENPSMEISFI 917
            .: .|..|...:...::|..||...:                   |...|.|.||...|.....:
Mouse  1229 LN-CCVFCKADELFTEYESKLFFNTVKGQTAIFEEMIEDEEGLVDDRVPTTTRGLWAVSETERSM 1292

  Fly   918 KSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTD 982
            |:|.:|.||.:...|:.:|....::|....:...|...:||:.:...|.|.|||.|...|:.:..
Mouse  1293 KAILSFARSHRFDVEYVDEGSVSMDLFEAWKKEYKLLHEYWMTLRNRVSAVDELAMATERLRVRH 1357

  Fly   983 DPEEQSN---YRILACQLDEQLQFNQYN---LQTSQLNFTRLCGRLKYLKHLKEDSADK------ 1035
            ..|.:.|   :.|:.....||.:....|   :.||||.  :..|:|.||.:| |.|.||      
Mouse  1358 PKEPKPNPPVHHIIEPHEVEQNRIKLVNDKAVATSQLQ--KKLGQLLYLTNL-EKSQDKTSGGIN 1419

  Fly  1036 --PCPICQTQDDVRYVMMVCGHFVCQHC----LDSMRRKNGRAGVTKCPLCRQDSPQLYYSVRPG 1094
              |||||..|...::.::.|||..|..|    ::.....:.|:.: ||.:|||.:          
Mouse  1420 PEPCPICARQLGKQWAVLTCGHCFCNECTSIIIEQYSVGSHRSSI-KCAICRQTT---------- 1473

  Fly  1095 AHKSII-----------------GDFSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIARA 1142
            :||.:.                 |..|||:.:||..::||:..:...|.:|||.||.:|..|::|
Mouse  1474 SHKEVSYVFTSEKANQEDDIPVKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKA 1538

  Fly  1143 LSLNGIQF----RNKCTNKDFDDFK-NPLSNVTCLLMPLSKGSKGLNLIEATHVFLVEPILNPGD 1202
            |:.|.::|    |.|...::...|| :|..|:  ||:||..||.||.:||||||.||||||||..
Mouse  1539 LTDNNMEFTQISRIKTFQENLSAFKYDPHINI--LLLPLHTGSNGLTIIEATHVLLVEPILNPAH 1601

  Fly  1203 ERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSLITSADDTTTLST--HWDLENMTLDSLKKLF 1265
            |.|||||:||.||.:||.||||::..||||.:.:::.:|:.:.|.|:  |.:...:|:..|..||
Mouse  1602 ELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTSSSGKHSEASVLTVAGLADLF 1666

  Fly  1266 ILKEE 1270
            ..:.|
Mouse  1667 TKENE 1671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7376NP_001261471.1 SNF2_N 221..601 CDD:278600 155/630 (25%)
PHD_SF 281..320 CDD:304600 19/44 (43%)
TPR 636..669 CDD:197478 10/32 (31%)
RING 1037..1083 CDD:238093 15/49 (31%)
HepA <1096..1238 CDD:223627 70/163 (43%)
Helicase_C 1108..1214 CDD:278689 52/110 (47%)
ShprhNP_001071175.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
DEAD-like_helicase_N 298..>382 CDD:391939 37/89 (42%)
DEAD-like_helicase_N 299..>419 CDD:391939 40/125 (32%)
Linker_histone 435..506 CDD:366156 3/70 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..548 0/23 (0%)
PHD_SHPRH 651..697 CDD:277022 19/45 (42%)
DEXQc_SHPRH <693..894 CDD:350828 77/212 (36%)
DEAQ box 810..813 2/2 (100%)
HepA <1314..1669 CDD:223627 125/370 (34%)
RING-HC_SHPRH 1420..1470 CDD:319483 14/50 (28%)
RING-HC finger (C3HC4-type) 1423..1469 CDD:319483 13/46 (28%)
SF2_C_SNF 1499..1624 CDD:350180 62/126 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 246 1.000 Domainoid score I2169
eggNOG 1 0.900 - - E2759_KOG0298
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6489
Inparanoid 1 1.050 467 1.000 Inparanoid score I1519
Isobase 1 0.950 - 0 Normalized mean entropy S6471
OMA 1 1.010 - - QHG49298
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004218
OrthoInspector 1 1.000 - - oto94485
orthoMCL 1 0.900 - - OOG6_104134
Panther 1 1.100 - - LDO PTHR45865
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3395
SonicParanoid 1 1.000 - - X2964
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.810

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