DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7376 and SHPRH

DIOPT Version :9

Sequence 1:NP_001261471.1 Gene:CG7376 / 38715 FlyBaseID:FBgn0035689 Length:1270 Species:Drosophila melanogaster
Sequence 2:XP_016866180.1 Gene:SHPRH / 257218 HGNCID:19336 Length:1744 Species:Homo sapiens


Alignment Length:1475 Identity:392/1475 - (26%)
Similarity:610/1475 - (41%) Gaps:429/1475 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 DALYEKHRQTVHVEQERSLDLPKRFQS---QLRKYQQRTVSWMLGREQQITQVPANFIVLHAI-- 191
            |.||...:|| |.::.:|:.:..:..:   .||.||:..|:||| :::.....||....||.:  
Human   274 DELYHFVKQT-HQQETQSIQVDVQHPALIPVLRPYQREAVNWML-QQECFRSSPATESALHFLWR 336

  Fly   192 -----DGITRVFKHKY--C-LQFYPFEEEIPKISLPPGGILADEMGLGKTVEFLAMLLMNPR--- 245
                 :|: :::.:.|  | ::.||  ...|::.   |||||||||||||||.||::|.:.|   
Human   337 EIVTSEGL-KLYYNPYTGCIIREYP--NSGPQLL---GGILADEMGLGKTVEVLALILTHTRQDV 395

  Fly   246 PQDS------------------------------------------------------------- 249
            .||:                                                             
Human   396 KQDALTLPEGKVVNYFIPSHYFGGKLKKTEIQNIEFEPKEKVQCPPTRVMILTAVKEMNGKKGVS 460

  Fly   250 -----------YRNDYWHQRL-----------------------------------EEFSDEV-- 266
                       ||.|....|.                                   |:..|:.  
Human   461 ILSIYKYVSSIYRYDVQRNRSLLKRMLKCLIFEGLVKQIKGHGFSGTFTLGKNYKEEDICDKTKK 525

  Fly   267 -----PLK---------------------------------------RSRISKK----------- 276
                 |.|                                       ||::.||           
Human   526 QAVGSPRKIQKETRKSGNKDTDSEYLPSDTSDDDDDPYYYYYKSRRNRSKLRKKLVPSTKKGKSQ 590

  Fly   277 ----------------------------------------------------------------- 276
                                                                             
Human   591 PFINPDSQGHCPATSDSGITDVAMSKSTCISEFNQEHETEDCAESLNHADSDVPPSNTMSPFNTS 655

  Fly   277 DEVF-CICTK----KHGKRVQCTKCRRWQHEMCMTISEKS--DLPHLCPSCWSELVKSGERLVES 334
            |..| |||.:    ....||||.||..|||..|:...||:  ..|..||.|...:     ..|.:
Human   656 DYRFECICGELDQIDRKPRVQCLKCHLWQHAKCVNYDEKNLKIKPFYCPHCLVAM-----EPVST 715

  Fly   335 GATIIVSPNAIKMQWFEEIHKHI-SPSLKVLLYFGLHSTFWVSPFDLAQYDVVLTDYTILRNEIY 398
            .||:|:||::|..||.:||::|: |.||:||:|.|:....::.|..||:.|:|:..|.:||:|:.
Human   716 RATLIISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELN 780

  Fly   399 HT----TDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESSTSAAAEMVRMLPAINRWA 459
            :.    ::.:..|::|:|:|||...|||:.|.|||:|||||||||..|..||||.:.|..||||.
Human   781 YVDIPHSNSEDGRRLRNQKRYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWC 845

  Fly   460 VTGT-----IDELPPLLEFVGRPEVCRPPDAWQTVDKAFQLNYK--C----EPLLELLEHSLWRT 513
            ::||     :::|..|:.|:|....|  ...|..     :|.|:  |    :.|...:...|||:
Human   846 ISGTPVQRGLEDLFGLVVFLGIEPYC--VKHWWV-----RLLYRPYCKKNPQHLYSFIAKILWRS 903

  Fly   514 CKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNSSCLASISP 578
            .|..|..::.||||||.:|.|..|.||..:|..:|..|.:.    |....|..:|.:..|:|:..
Human   904 AKKDVIDQIQIPPQTEEIHWLHFSPVERHFYHRQHEVCCQD----VVVKLRKISDWALKLSSLDR 964

  Fly   579 QLLRIILKPFLRIRQTCSVPVVFNSNV----SSTDYLHPQDLLARLKSNNENECKTELRTWASSY 639
            :.:..||.|.||:||.|..|.......    .||  :..::||..|:.....||:...|....:.
Human   965 RTVTSILYPLLRLRQACCHPQAVRGEFLPLQKST--MTMEELLTSLQKKCGTECEEAHRQLVCAL 1027

  Fly   640 NGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYNLLQASSLAPAEHK--LT 702
            ||||.|:.||.::..|.:.|..:|: ::|.::..:..||:.::||.:||::   |..|.|.  ..
Human  1028 NGLAGIHIIKGEYALAAELYREVLR-SSEEHKGKLKTDSLQRLHATHNLME---LLIARHPGIPP 1088

  Fly   703 ELEHKKYQAQMSRLEWKYLED-NTRVLESALSSYNENLEKVSELEKRFEGSTLDLLATMVNHKTS 766
            .|...:.:.:..:|...|:.. ||.|.|:..:.|... :.:.||:::.             |..|
Human  1089 TLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALYPVQ-QTIHELQRKI-------------HSNS 1139

  Fly   767 ------LHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTLIAEFEFLKG 825
                  :|.||...: |:...|.:..|...|.....|.|...:.:.: .:.|:..|..:.|.|..
Human  1140 PWWLNVIHRAIEFTI-DEELVQRVRNEITSNYKQQTGKLSMSEKFRD-CRGLQFLLTTQMEELNK 1202

  Fly   826 VMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPKKHRYCRLCLIRDSLNQFEC 890
            ..:...||:|.  |......|.||:.|||||         :|.:...: .|..|...:...::|.
Human  1203 CQKLVREAVKN--LEGPPSRNVIESATVCHL---------RPARLPLN-CCVFCKADELFTEYES 1255

  Fly   891 LLFAKK------------------LDEKA-TVTEGLENPSMEISFIKSIFAFLRSKQDFSEWKEE 936
            .||:..                  :|::| |.|.||...|.....:|:|.:|.:|.:...|:.:|
Human  1256 KLFSNTVKGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAILSFAKSHRFDVEFVDE 1320

  Fly   937 CQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKMRILLTDDPEEQSNYRILACQLDEQL 1001
            ..:.::|....:...|...:||:.:...|.|.|||.|...|:.:.|..|.:.|..:|......::
Human  1321 GSTSMDLFEAWKKEYKLLHEYWMALRNRVSAVDELAMATERLRVRDPREPKPNPPVLHIIEPHEV 1385

  Fly  1002 QFNQYNL------QTSQLNFTRLCGRLKYLKHLKEDSADK--------PCPICQTQDDVRYVMMV 1052
            :.|:..|      .||||.  :..|:|.||.:| |.|.||        |||||..|...::.::.
Human  1386 EQNRIKLLNDKAVATSQLQ--KKLGQLLYLTNL-EKSQDKTSGGVNPEPCPICARQLGKQWAVLT 1447

  Fly  1053 CGHFVCQHCLDSMRRK----NGRAGVTKCPLCRQDSPQLYYSVRPGAHKSII------------- 1100
            |||..|..|:..:..:    :.|:.: ||.:|||.:          :||.|.             
Human  1448 CGHCFCNECISIIIEQYSVGSHRSSI-KCAICRQTT----------SHKEISYVFTSEKANQEED 1501

  Fly  1101 ----GDFSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIARALSLNGIQF----RNKCTNK 1157
                |..|||:.:||..::||:..:...|.:|||.||.:|..|::||:.|.::|    |.|...:
Human  1502 IPVKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFAQISRVKTFQE 1566

  Fly  1158 DFDDFK-NPLSNVTCLLMPLSKGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKV 1221
            :...|| :|..|:  ||:||..||.||.:||||||.||||||||..|.|||||:||.||.:||.|
Human  1567 NLSAFKRDPQINI--LLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIV 1629

  Fly  1222 HRFIVNETIEENILSLITSADDTTTLSTHWDLENMTLDSLKKLFI 1266
            |||::..||||.:.:::.:|:     ..:|          ||.||
Human  1630 HRFLIKATIEERMQAMLKTAE-----RRYW----------KKQFI 1659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7376NP_001261471.1 SNF2_N 221..601 CDD:278600 159/634 (25%)
PHD_SF 281..320 CDD:304600 18/44 (41%)
TPR 636..669 CDD:197478 10/32 (31%)
RING 1037..1083 CDD:238093 15/49 (31%)
HepA <1096..1238 CDD:223627 71/163 (44%)
Helicase_C 1108..1214 CDD:278689 52/110 (47%)
SHPRHXP_016866180.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 242 1.000 Domainoid score I2232
eggNOG 1 0.900 - - E2759_KOG0298
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6489
Inparanoid 1 1.050 473 1.000 Inparanoid score I1515
Isobase 1 0.950 - 0 Normalized mean entropy S6471
OMA 1 1.010 - - QHG49298
OrthoDB 1 1.010 - - D110877at33208
OrthoFinder 1 1.000 - - FOG0004218
OrthoInspector 1 1.000 - - oto90903
orthoMCL 1 0.900 - - OOG6_104134
Panther 1 1.100 - - LDO PTHR45865
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3395
SonicParanoid 1 1.000 - - X2964
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

Return to query results.
Submit another query.