DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fmt and PPP6R2

DIOPT Version :9

Sequence 1:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_011529034.1	Gene:	PPP6R2 / 9701	HGNCID:	19253	Length:	990	Species:	Homo sapiens

Alignment Length:	954	Identity:	246/954 - (25%)
Similarity:	386/954 - (40%)	Gaps:	270/954 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65
            |||......:::::.||:||:.||:|.:||:|||||||.|.:.|:::..|.:.:..||.|||.:|
Human    23 MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDP 87

  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130
            ..|:....||:|.|.:||:||..:|.:.::|..|...|.|||.:|:.||||||||:||||||...
Human    88 PLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGN 152

  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195
            |..:|.|           |::.::|.:..|:..:.||..|..:.||:::::..:|...|::::..
Human   153 LIARKTE-----------QVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQDVLH 206

  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTI 260
            ||.|:|:::||:.::...|:.|:.:|.:...||::..||  .|..|..::.||     :|:|..:
Human   207 WLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGR--DQGSQLQEALEP-----DPLLTAL 264

  Fly   261 EF-ADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRLLQKREREIHQEVQE 324
            |. .|.:|.||..:.:.:..||.::||..|:|||::......|...|  ...|..||.  ..|..
Human   265 ESRQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVD--SFSQGLERS--YAVSS 325

  Fly   325 TVITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLETKHETIQQAICA 389
            :|:..:.|||::|..:|.|||.|..:.||..||..|.|..||...|:..|||.|...:|.|.:|.
Human   326 SVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCR 390

  Fly   390 TEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINAFLKVGTE 454
            .....||||.|.:|.||||||.:
Human   391 LNTMDLLLDLFFKYTWNNFLHFQ------------------------------------------ 413

  Fly   455 ESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQEHEEHMSQVEAA 519
                                      :|:.:||....||:                      |..
Human   414 --------------------------VELCIAAILSHAAR----------------------EER 430

  Fly   520 AEATASED-AEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPSEMQSHLIVNCH 583
            .||:.||. .||..::..                     ..|:..:...|.|.:.|.:||...|.
Human   431 TEASGSESRVEPPHENGN---------------------RSLETPQPAASLPDNTMVTHLFQKCC 474

  Fly   584 LISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKILR-------------HITNCI----------- 624
            |:.::::.|:.|...|:| .|.|.|.||||.:|..             ||:..|
Human   475 LVQRILEAWEANDHTQAA-GGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRW 538

  Fly   625 ----------SESEHIGDLIT-----SSLSDED-------EVKLWQSLIDAETGEFSLAVKQQTK 667
                      :...:..||::     ||..|||       |:.|.|:..|.:       ::|.|.
Human   539 ESFVEETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQ-------IQQMTA 596

  Fly   668 LLAD---CNPHEENQYNDGSN---DYTGEINAWNVGNLPYREVDCSELNNTLQDIFFAIDQNRFQ 726
            ...|   .|..|....:|..|   |...|||.         .:|..| ::....:|.|...:|.|
Human   597 NFVDQFGFNDEEFADQDDNINAPFDRIAEINF---------NIDADE-DSPSAALFEACCSDRIQ 651

  Fly   727 FGRNIDDEDDDD----------------------------DEHGDHSGGGDGH----------GH 753
               ..||::|:|                            .::|...||.||.          |.
Human   652 ---PFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGA 713

  Fly   754 GM----FTKNSNTLNNLADPWDIQFAVL----SSAPTQV----NTGTANW--GTDFNSD----NF 800
            |.    ..|.:..:...::...:..||.    :|.||..    :.|::.|  ||....:    .|
Human   714 GAPPAPGKKEAPPVEGDSEAGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKF 778

  Fly   801 ADFDAHFSTFGSDLGMPISAPPGEE---EEEDSSPAPESATQVN 841
            .||.....   |:.|...|:|...|   .|...|..||.|:|.:
Human   779 TDFQPFCC---SESGPRCSSPVDTECSHAEGSRSQGPEKASQAS 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	89/336 (26%)
PPP6R2	XP_011529034.1	SAPS	150..555	CDD:282368	124/538 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149450
Domainoid	1	1.000	134	1.000	Domainoid score	I5014
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2838
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	1	1.000	-	-		otm40469
orthoMCL	1	0.900	-	-		OOG6_100938
Panther	1	1.100	-	-	LDO	PTHR12634
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R385
SonicParanoid	1	1.000	-	-		X542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780