DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fmt and SAP4

DIOPT Version :9

Sequence 1:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_011285.1	Gene:	SAP4 / 852622	SGDID:	S000003198	Length:	818	Species:	Saccharomyces cerevisiae

Alignment Length:	817	Identity:	148/817 - (18%)
Similarity:	277/817 - (33%)	Gaps:	239/817 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKGYAPSANIEALLEKEN--------STLEEFLDEEDILQECK-TQKKNLVN-------YFTRPE 52
            ||...||...|:....|:        |.::..|.|..:|.|.. .....||:       |..|.:
Yeast    39 DKKNEPSMESESEFGTESRDRSDLNQSFIDRILLETALLDELNGAANDRLVDFICLGYFYDDRSQ 103

  Fly    53 VIRR---LVELI-----------------------TTEPSEDVPMSKRFRYANMSCEILTLGLPS 91
            .:|.   ||:::                       .|...||........|.|:...|.......
Yeast   104 QVRHMDYLVDMLMAYLKDIDRTGYRTPFLLENSFHQTGEYEDQDDEDPMLYVNIISSIFCSKSAP 168

  Fly    92 LDEKLLNDAETLQLLYSYLEKEPPLN------PLLSSFFSKTFSMLFTKKPEQDWFLYQHMCLQL 150
            :.|.|:.:...|..|:...:.|   |      |:|:.|.....::||.:..            ..
Yeast   169 IVEALVQNTPFLSSLFEVFQFE---NIEAENCPILAVFLKINETLLFEQTS------------SY 218

  Fly   151 LEYIKSQKTFLDFICKHFD-TPVIPDLIMQMMKD-IEGGRLKRNLFEWLTEDKIVERLIAILRNP 213
            ||:.|||...:|....|.: :|::..||..|:.| :|.   ..|:.::|....::.:.:.:|.|.
Yeast   219 LEFFKSQPNIVDKFLYHIEVSPLVEFLIKIMLTDQVES---PTNIIDFLYHQDLIPKCLNLLENS 280

  Fly   214 QETDKHANVADFFCDLINQGRLMRQ--TEQENDSFEPAFDGSNPILKTIEFADTIEALLNVILEP 276
            :.:....|         :.|.|::.  :...|...:..:.|.|.:.:.:.....::.|:|:||..
Yeast   281 KYSPGIQN---------SSGELLKALISISTNFKLDTLWIGPNRLTRQLASPQYVDQLINIILFQ 336

  Fly   277 NAQESAILSGISVVLTLIK------------PITFTDEPNSDRQ-------------------RL 310
            ......:  .:|:::.||:            ..|..|.|.|.|.                   .|
Yeast   337 RGHAMGV--AVSIIIELIRKNNSDYDEVDLLSTTIVDNPPSQRDPVYLGHLLYELTMHMEDFYAL 399

  Fly   311 LQKREREIHQEVQETVITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTAL 375
            |.|.|.: ..:..:|....: |.::.  |:|:|     .|..:..    |.|..|:::..:.:.:
Yeast   400 LIKLEND-DDDDHDTASKAL-PSVKH--HLLEN-----QLHESFR----PLGFERVKITELISEM 451

  Fly   376 LETKHETIQ-----QAICATEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEV 435
            |...:..:.     :.|..|          :..|.:......:|||:..:   .:::|...|..:
Yeast   452 LHCSNMGLMNSKRGEKIART----------RDKCRDTLDQNSLEKAMKNL---NINDNTITSNTL 503

  Fly   436 TDYFTADCLINAFLKVGTEESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQ 500
            .|            |....:|     |..||.::.:....::..|.|:         ..|.|
Yeast   504 ED------------KCNNNDS-----NDSNDNQKQKKNIKKKFHDNEL---------YSTFD--- 539

  Fly   501 TAAEENQEHEEHMS-QVEAAAEA---------TASEDAEPKAQD--------------------- 534
             .:::|.:.::.|| ::...:|.         |..:..:.|..|
Yeast   540 -TSDDNIDDDDDMSFEIPYVSETQNLKIRKNPTIGDLFKIKLHDLGFFPKFLQLFLRYPWNNFWH 603

  Fly   535 -------NEVKNSEVDGESPTDQQESEATLNDLDK-TKTVPSPPPSEMQSHLIVNCHLISKLVDL 591
                   .::.|..:|....:....|   |.|..| |:.:|.|.....|...:.:.|:||..: |
Yeast   604 NIVFDIIQQIFNGRMDFSYNSFLVYS---LFDFKKSTRFIPKPLYGSNQKLPVKDFHIISDFI-L 664

  Fly   592 WQHNAQAQSAEKGR-RLGYMGHLIKILRHIT--NCISESEHIGDLITSSLSDEDEVKLWQSLIDA 653
            ..|....:..||.: .|||||.|:.|...|.  :.|.:::.|...|.:.|.||    :|.|
Yeast   665 QGHKDSFEFYEKEKTNLGYMGQLVLIAEEIAKYSKIYKTDLIAPDIYAFLQDE----VWMS---- 721

  Fly   654 ETGEFSLAVKQQTKLLAD--------CNPHEENQYND 682
                :|..:..:|:.:..        |...:||...|
Yeast   722 ----YSSDILNETRTMCSIILGGGQFCAESDENTNQD 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	63/375 (17%)
SAP4	NP_011285.1	SAPS	207..736	CDD:282368	111/626 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1595
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12634
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X542
TreeFam	0	0.000	Not matched by this tool.
	8	7.890