DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fmt and SAP155

DIOPT Version :9

Sequence 1:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_116698.3	Gene:	SAP155 / 850601	SGDID:	S000001936	Length:	1002	Species:	Saccharomyces cerevisiae

Alignment Length:	940	Identity:	163/940 - (17%)
Similarity:	315/940 - (33%)	Gaps:	322/940 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEPSEDVPMSKRFRYANMSCEI 84
            |:.|.:|...|:|.....|.::|...:.|...::.....:....|..|...::|    |.:..||
Yeast   228 ESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDESAYLTK----ATIISEI 288

  Fly    85 LTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLN----PLLSSFFSKTFSMLFTKKPEQDWFLYQH 145
            .:|.:..:.|.|:.:...|..::|.: .:|..|    ||:..|.....::|.|:   ||
Yeast   289 FSLDIWLISESLVKNQSYLNKIWSII-NQPNFNSENSPLVPIFLKINQNLLLTR---QD------ 343

  Fly   146 MCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMK--DIEGGRLKRNLFEWLTEDKIVERLIA 208
               |.|.:|:::::|:|.:.||.|..::.|..::::.  .||.   ...:.|.:.:..::.:.::
Yeast   344 ---QYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIES---PTGIIELVYDQNLISKCLS 402

  Fly   209 ILRNPQE-TDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTIEFADTIEALLNV 272
            .|.|.:. .|..|.|.||...||        ....|...:....|.|.:.:.:...::|..|:::
Yeast   403 FLNNKESPADIQACVGDFLKALI--------AISANAPLDDISIGPNSLTRQLASPESIAKLVDI 459

  Fly   273 ILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRLLQKREREIHQEVQETVITVMAPRLQEF 337
            ::  |.:.:|:.:.:|:|:.||:      :.|||..::
Yeast   460 MI--NQRGAALNTTVSIVIELIR------KNNSDYDQV--------------------------- 489

  Fly   338 VHILKNPPAKPTLETTAAVLTPPFGKTRL---QVCRVFTALLETKHETIQQAICATEYFSLLLDF 399
                       .|.||.....||..:..:   .:.|.|:..|             :::|.::||.
Yeast   490 -----------NLLTTTIKTHPPSNRDPIYLGYLLRKFSNHL-------------SDFFQIILDI 530

  Fly   400 FKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINAFLKVGTEESEV-----E 459
                                        .|.|:..:.:    :.|...|..:|.|..:|     |
Yeast   531 ----------------------------ENDANIPLHE----NQLHEKFKPLGFERFKVVELIAE 563

  Fly   460 MKNALN----DAKRAEGGKDEEGGDIEIEVAAAQE-VAAQTPDERQTAAEENQEHEEHMSQVEAA 519
            :.:..|    ::||||            .:|..:: |.:|.....|.|.  |....|...|::..
Yeast   564 LLHCSNMGLMNSKRAE------------RIARRRDKVRSQLSHHLQDAL--NDLSIEEKEQLKTK 614

  Fly   520 AEATASEDAEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVP------------SPPPS 572
            ...|...|.:.|..:.::.|...|.:..:|..:      ::|::..:|            .|...
Yeast   615 HSPTRDTDHDLKNNNGKIDNDNNDNDDESDYGD------EIDESFEIPYINMKQNIKLRTDPTVG 673

  Fly   573 EMQSHLIVNCHLISKLVDL-----WQ---HNAQAQ------------------------------ 599
            ::....:.:..::||:::|     |.   ||....
Yeast   674 DLFKIKLYDTRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQ 738

  Fly   600 -------SAEKG---------------------------------------RRLGYMGHLIKILR 618
                   |.|||                                       ..||||||::.|..
Yeast   739 FMTDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHIVLIAE 803

  Fly   619 HITNCISESEHIGDLITSSLSDEDEVKLWQ---------------------SLIDAETGEFSLAV 662
            .:.. .|:...: :||:..:....:.:.||                     |.||...|.....:
Yeast   804 EVVK-FSKLYKV-ELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYIDDGNGNIIPQL 866

  Fly   663 KQQTKLLADCNPHEENQYNDGSNDYTGEINAWNVG----NLPYREVDC-----SELNNTLQDIFF 718
            ...|.:|........|  |:..:..||..|..:.|    |:...|...     |:|:|.|:::..
Yeast   867 PDNTTVLTPNGDASNN--NEILDSDTGSSNGTSGGGQLINVESLEEQLSLSTESDLHNKLREMLI 929

  Fly   719 AIDQNRFQFGRNIDDEDDD---------DDEHGDHSGGGDGHGHGMFTKNSNTLNNLADPWDIQF 774
                ||.|  .::|:::.:         :|::.:.:.....|.......|.|..||..|
Yeast   930 ----NRAQ--EDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNNNDNNDNNDND------ 982

  Fly   775 AVLSSAPTQVNTGTANWGTDFNSDNFADFD 804
                      |..|.|:..|.::||  |:|
Yeast   983 ----------NDNTRNYNEDADNDN--DYD 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	58/346 (17%)
SAP155	NP_116698.3	SAPS	334..847	CDD:398279	102/648 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1595
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12634
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X542
TreeFam	0	0.000	Not matched by this tool.
	8	7.890