DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fmt and ppp6r2a

DIOPT Version :9

Sequence 1:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001020680.1	Gene:	ppp6r2a / 560729	ZFINID:	ZDB-GENE-030131-5428	Length:	878	Species:	Danio rerio

Alignment Length:	1042	Identity:	253/1042 - (24%)
Similarity:	427/1042 - (40%)	Gaps:	251/1042 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65
            |||......:::|:.||::|..||.|.::|||:|||||.|.:.|:.:.::...::.||.|||.||
Zfish     1 MFWKFDLNNTSHIDQLLDREGVTLRELMEEEDVLQECKAQNRKLLLFLSKDHCMQELVTLITEEP 65

  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130
            ..|:....||::.|::||:||..:..:::||..|...|:.||.:||:||||||||:||||||...
Zfish    66 PADLEEKTRFKFPNIACELLTSDVALINDKLGGDESLLEKLYHFLEQEPPLNPLLASFFSKTIGN 130

  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195
            |..:|.:           |::.:::.:..|:..:..|.|...:.||:::::..:|...|:..:..
Zfish   131 LIARKTD-----------QVISFLRKKHNFISLVLNHIDASAMMDLLLRLISCVEPAPLRMEVLN 184

  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTI 260
            ||.|:::::||..::...::.::.:|.:...||:|   ||.|  :|.|...|  ...|:|:|..:
Zfish   185 WLNEERLIQRLTELMHTGRDEERQSNASQTLCDII---RLSR--DQANQLSE--VTDSDPLLAVL 242

  Fly   261 EFADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRL-----LQKREREIHQ 320
            |..:.:..||..:.|....|:::::|..|:|||::         |.|..|     |..:..|...
Zfish   243 ESQENVAELLKNMFEGERSEASVVNGTQVLLTLLE---------SRRSGLEGLMDLYSQGCERSY 298

  Fly   321 EVQETVITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLETKHETIQQ 385
            .|..:::..:.|.|::|..:|.|||.:..:.||..||..|.|..||.|.|:..:||:|...:|.|
Zfish   299 TVNSSILRAIEPHLKDFQQLLLNPPTRSAILTTVGVLEQPLGSARLHVARLVASLLQTCDLSICQ 363

  Fly   386 AICATEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINAFLK 450
            .||......||||.|.:|.||||||.::|..:..:.      |::|..:|
Zfish   364 EICRLNTMDLLLDLFFKYTWNNFLHLQVELCVASIL------NHSAHADV--------------- 407

  Fly   451 VGTEESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQEHEEHMSQ 515
                                                       |.|.        .|.|||..:
Zfish   408 -------------------------------------------QNPG--------LQNHEERPA- 420

  Fly   516 VEAAAEATASEDAEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPSEMQSHLIV 580
                                            ||.|..|.|......:....:|....:.::|..
Zfish   421 --------------------------------TDNQTEEGTPGQNSSSDPANTPIQDALVANLFQ 453

  Fly   581 NCHLISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKILRHITNCISES---EHIGDLITSSLSDED 642
            :|.|:.:::|.|:.|.:.|: |.|||.|.||||.:|...:...:.:.   ..|.|||..  ..||
Zfish   454 HCRLVQRILDAWEENDKIQT-EGGRRRGNMGHLTRIANTVVQNLEKGLAHSQINDLIKE--LPED 515

  Fly   643 EVKLWQSLIDAETGEFSLAVKQQTKLLADCNPHEENQYNDGSNDYTGEIN--------------A 693
            ....|:|.:.....|.:.  :....|::..|.|..::.:|..:.:..:::              |
Zfish   516 CRGRWESFVGETLRETNR--RNTVDLVSTHNLHSSSEDDDMESPFPNDLSIQQAFSDYQIQQMTA 578

  Fly   694 WNVGNLPYREVDCSELNNTLQDIFFAIDQNRFQFGRNIDDED-------------------DDDD 739
            ..|....:.:.:.||.:..:...|..|.:..|    |||.:|                   ||.:
Zfish   579 NFVDQFGFNDEEFSEHDENINAAFDRIAEINF----NIDADDHSANAAAFEACCKERIQQFDDCE 639

  Fly   740 EHGDHSGGGDGHGHGMFTKNSNTLNNLADPWDIQFAVLSSAPTQVNTGTANWGTDFNSDNFADFD 804
            |..|                      :.|..:|.:|      ||:.: .:.:|...:||:
Zfish   640 EEED----------------------IWDEKEINYA------TQIKS-RSRFGVSLSSDS----- 670

  Fly   805 AHFSTFGSDLGMPISAPPGEEEEEDSSPAPESATQV-NP-------EEERQPAESIGLAV---GK 858
            :..|...:..|...||...|:.||::||...:..|. ||       |.|...:.|.|.:.   .:
Zfish   671 SPKSAVRNGGGGRGSASEEEDVEEEASPQQSAGAQTQNPGWTASFGEAEVSASGSWGNSPQQGSE 735

  Fly   859 GVQDN----------LACTDDQQAEYDNNANVEK--AISDKLA---ESSVVETAAIVTRLQSVLL 908
            |.||.          .:.|:..|.|.......||  |.||...   |.|..:.|.:|....|  .
Zfish   736 GQQDTGWASFTEFQPFSSTESSQTEGQPQQGEEKNLASSDSATGAWEESSGQKAPLVASDSS--S 798

  Fly   909 DGEDDYEDDEGMWTKPLGADRPSETEQITPISNGPDSKVNELGLPFSNHANDISSNNVDGHEANI 973
            .|..|.|:|.|. .|..|:.:....:.....|:.|...:.:|.:      .|.|.::....|::.
Zfish   799 SGGSDSEEDPGE-NKTQGSPKTPANQTTASSSDVPTEALKKLSI------TDSSESSAPTEESDA 856

  Fly   974 TT 975
            ||
Zfish   857 TT 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	84/340 (25%)
ppp6r2a	NP_001020680.1	SAPS	128..537	CDD:309582	122/545 (22%)
ppp6r2a	NP_001020680.1	Glutenin_hmw	<697..>820	CDD:281191	32/125 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583578
Domainoid	1	1.000	142	1.000	Domainoid score	I4624
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2306
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	1	1.000	-	-		otm26415
orthoMCL	1	0.900	-	-		OOG6_100938
Panther	1	1.100	-	-	LDO	PTHR12634
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R385
SonicParanoid	1	1.000	-	-		X542
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780