Protein Alignment fmt and PPP6R3

DIOPT Version :9

• Sequence 1: NP_001261470.1
• Gene: fmt / 38714
• FlyBaseID: FBgn0035688
• Length: 996
• Species: Drosophila melanogaster
• Sequence 2: NP_001339283.1
• Gene: PPP6R3 / 55291
• HGNCID: 1173
• Length: 889
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 269/1062 - (25%)
• Similarity: 432/1062 - (40%)
• Gaps: 309/1062 - (29%)

  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65
            |||......|::|:.|||:|:.||:|.:||||:|||||.|.:.|:.:..:.|.:..||..|..||
Human     1 MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEP 65

  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130
            .:|:....|::|.|:|||:||..:..::::|..|...|..|||:|..:.||||||:|||||..|:
Human    66 PQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSI 130

  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195
            |.::|||           |:::::|.:..|:|.|.||..|..|.||:::::..||..:.::::..
Human   131 LISRKPE-----------QIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLN 184

  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMR-QTEQENDSFEPAFDGSNPILKT 259
            ||.|:||::||:.|:...||.|:|:|.:...|:::   ||.| |..|..:|.||     :|:|.|
Human   185 WLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIV---RLSRDQMLQIQNSTEP-----DPLLAT 241

  Fly   260 IEFADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRLLQKREREIHQE--- 321
            :|..:.||.||:.|......||||:|.|.::|||::    |..|..           |.|.|
Human   242 LEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLE----TRRPTF-----------EGHIEICP 291

  Fly   322 ---------VQETVITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLE 377
                     |.::|:..:..||..|..:|..||.|..::||..||.||.|.|||.|.|:.::||:
Human   292 PGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQ 356

  Fly   378 TKHETIQQAICATEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTAD 442
            |...:|...:.......::|:.|.:|.|||||||::|..:.::..:...|...|:  :||
Human   357 TNTSSINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENAT--ITD----- 414

  Fly   443 CLINAFLKVGTEESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQ 507
                                           :|..|.::
Human   415 -------------------------------QDSTGDNL-------------------------- 422

  Fly   508 EHEEHMSQVEAAAEATASEDAEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPS 572
                                                                             
Human   423 ----------------------------------------------------------------- 422

  Fly   573 EMQSHLIVNCHLISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKILRHITNCISESEHIGD---LI 634
             :..||...|.||.::::.|:.|.:.| ||.|||.||||||.:    |.|||..|...|.   |:
Human   423 -LLKHLFQKCQLIERILEAWEMNEKKQ-AEGGRRHGYMGHLTR----IANCIVHSTDKGPNSALV 481

  Fly   635 TSSLSD-EDEVK-LWQSLIDAETGEFSLAVKQQT-KLLADCNPH---------------EENQYN 681
            ...:.| .|||: .|::...:..||.:   |:.| .|:..|:.|               :::...
Human   482 QQLIKDLPDEVRERWETFCTSSLGETN---KRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQ 543

  Fly   682 DGSNDYTGEINAWN-----------------VGNLPYREVDCSELNNTLQD-------IFFAIDQ 722
            ...:||..:....|                 :||:.:..|  |::|.||..       :|.|..:
Human   544 QAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRV--SDINFTLNTNESGNIALFEACCK 606

  Fly   723 NRF-QFGRNIDDEDD---------------------DDDEHGDHSGGGDGHGHGMFTKNS-NTLN 764
            .|. ||.....||:|                     .|.|....|...||....:|..:| ||.:
Human   607 ERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTED 671

  Fly   765 ----NLADP--W----DIQFAVLSSAPTQVNTGTANWGTDFNSDNFADFDAHFSTFGSDL----- 814
                :|::|  |    |:.......||.. :.|:..|.|:..........|.||.|.|.|
Human   672 KMEVDLSEPPNWSANFDVPMETTHGAPLD-SVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDS 735

  Fly   815 ---GMPISAPPGEEEEEDSSPA-------PESATQV------NPEEERQPAESIGLAV-GKGVQD 862
               ..|:......|..:..:|:       ||:|..|      :.||:.:..:.:...| ..|:::
Human   736 LRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKE 800

  Fly   863 NLACTDDQQAEYDNNANVEKAISDKLAESSVVETAAIVTRLQSVLLDGEDDYEDDEGMWTKPLGA 927
            .|:.|.|        |..|.|:..::.: |..|...:.|...:...|.|:..|..|.....|
Human   801 TLSLTVD--------AKTETAVFKRVLK-SYREEGKLSTSQDAACKDAEECPETAEAKCAAP--- 853

  Fly   928 DRPSETEQITPISNGPDSKVNE 949
                     .|.|:.|:...::
Human   854 ---------RPPSSSPEQSASD 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	103/348 (30%)
PPP6R3	NP_001339283.1	SAPS	128..513	CDD:309582	139/556 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149449
Domainoid	1	1.000	134	1.000	Domainoid score	I5014
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2838
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	1	1.000	-	-		otm40469
orthoMCL	1	0.900	-	-		OOG6_100938
Panther	1	1.100	-	-	O	PTHR12634
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R385
SonicParanoid	1	1.000	-	-		X542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780