DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fmt and PPP6R1

DIOPT Version :9

Sequence 1:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_055746.3	Gene:	PPP6R1 / 22870	HGNCID:	29195	Length:	881	Species:	Homo sapiens

Alignment Length:	1083	Identity:	245/1083 - (22%)
Similarity:	396/1083 - (36%)	Gaps:	342/1083 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65
            |||......|::::.|||:|:.:|.|.|||||:|||||...:.|:::..:|..::.:|..:|.||
Human     1 MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEP 65

  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130
            .:......|::|.:::|||||..:|.:::.|..|...|..||.:|:....|||||:|||||...:
Human    66 PDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGI 130

  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195
            |..:|.:           ||:.:::.:..|:|.:.:|..|..|.||:::::..:|..:|::::..
Human   131 LINRKTD-----------QLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVN 184

  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTI 260
            ||.|:|||:|||..:...::.::|:|.:...||:|...|  .|..|..||.||     :.:|.|:
Human   185 WLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSR--EQMIQVQDSPEP-----DQLLATL 242

  Fly   261 EFADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEP---NSDRQRLLQKREREIHQEV 322
            |..:|||.||:.:.|....:|.|:|||.|:|||::|.....|.   ||....:..:.|......:
Human   243 EKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGAL 307

  Fly   323 QETVITV-----MAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLETKHET 382
            :.||.:|     :.|||..|..:|..||....|:.|..:|.||.|.|||.|.::..:.|......
Human   308 ESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAA 372

  Fly   383 IQQAICATEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINA 447
            :...:.|.:..:.:||.|..|.:|||||.::|                           .| ::.
Human   373 LTHELLALDVPNTMLDLFFHYVFNNFLHAQVE---------------------------GC-VST 409

  Fly   448 FLKVGTEESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQEHEEH 512
            .|.:|
Human   410 MLSLG------------------------------------------------------------ 414

  Fly   513 MSQVEAAAEATASEDAEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPSEMQSH 577
                       ...|:.|:                                    :|..:.:..|
Human   415 -----------PPPDSSPE------------------------------------TPIQNPVVKH 432

  Fly   578 LIVNCHLISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKI---LRHITNCISESEHIGDLITSSLS 639
            |:..|.|:.:::..|:.|.:.|.| .|.|.||||||.::   |...|.....:|.:..|:....|
Human   433 LLQQCRLVERILTSWEENDRVQCA-GGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPS 496

  Fly   640 DEDEVKLWQSLID---AETGEFSLAVKQQTKLLADCNPHEENQYNDGSNDYTGEINAWNVGNL-- 699
            ::.|  .|::.:.   |||.:     |....|:   |.|..:..:|..:|...|.|......|
Human   497 EQQE--QWEAFVSGPLAETNK-----KNMVDLV---NTHHLHSSSDDEDDRLKEFNFPEEAVLQQ 551

  Fly   700 PYREVDCSELNNTLQDIFFAIDQN----------------RFQFGRNIDDE-------------- 734
            .:.:.....:.:...|.|...|:.                ...|..|.|||
Human   552 AFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDR 616

  Fly   735 ----DDDDDEHGDHSGGGDGHGHGMFTKNSNTLNNLADPWDIQFAVLSSAPTQVNTGTANWGTDF 795
                |||::|..:....|.|...|.           ...|.
Human   617 IQQFDDDEEEEDEEEAQGSGESDGE-----------DGAWQ------------------------ 646

  Fly   796 NSDNFADFDAHFSTFGSDL--GMPISAPPG----------------EEEEEDS------------ 830
                           ||.|  |..:..|||                ||||||.
Human   647 ---------------GSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGAT 696

  Fly   831 -----SPAPE------------------SATQVNPEEERQ---PAESIGLAVGKGV-QDNLACTD 868
                 ||.|:                  ::.:|:.|||..   ||....|:|.:|: ..:||...
Human   697 PLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPP 761

  Fly   869 DQQAEY--DNNANVEKAISDKLAESSVVETAAIVTRLQSV------------LLDGEDDYEDDEG 919
            .:.|..  ..:.....|..:....|.|.|.:|....|.|:            .....|....|..
Human   762 ARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPS 826

  Fly   920 MWTKPLGADRPSETEQITPISNGPDSKVNELGLPFSNHANDIS 962
            ......||.:|.:|   |.....|:    .||||.|..|..::
Human   827 TSVPASGAHQPPQT---TEGEKSPE----PLGLPQSQSAQALT 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	92/343 (27%)
PPP6R1	NP_055746.3	Interaction with PPP6C	10..403		135/410 (33%)
		SAPS	128..519	CDD:282368	122/551 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..881		57/299 (19%)
		PHA03195	<742..>875	CDD:177556	27/128 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149451
Domainoid	1	1.000	134	1.000	Domainoid score	I5014
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2838
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	1	1.000	-	-		otm40469
orthoMCL	1	0.900	-	-		OOG6_100938
Panther	1	1.100	-	-	O	PTHR12634
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R385
SonicParanoid	1	1.000	-	-		X542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780