Protein Alignment Prdm13 and ZNF335

DIOPT Version :10

• Sequence 1: NP_648032.1
• Gene: Prdm13 / 38713
• FlyBaseID: FBgn0035687
• Length: 465
• Species: Drosophila melanogaster
• Sequence 2: NP_071378.1
• Gene: ZNF335 / 63925
• HGNCID: 15807
• Length: 1342
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 59/303 - (19%)
• Similarity: 93/303 - (30%)
• Gaps: 102/303 - (33%)

  Fly   168 PFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHL------------ALGCG-RSAMDILWMRLHYA 219
            |.|.|        ::|.:|...|.:...|:.|:            .|.|. ||..   |..|...
Human   460 PLLRP--------FLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRR---WSSLKEH 513

  Fly   220 L---------KAAARSHTETQHSPIPATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMVP 275
            :         |....|:|......:...::..|......|.|  .|:.|:|           ..|
Human   514 MFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDP--TPKLSSF-----------PCP 565

  Fly   276 VTTAATPLSYLPSMSMATAPLSTNPMNAAAQIEAIVSNMGASKQGHLCIYCGKVYSRKYGLKIHI 340
            |.....|:....:..|.|                     .::::.|:|..|||.:.::|..|:|:
Human   566 VCGRVYPMQKRLTQHMKT---------------------HSTEKPHMCDKCGKSFKKRYTFKMHL 609

  Fly   341 RTH---TGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHP----------------SSSAGVADGG 386
            .||   ...:..||:||.....|...|..|...|:...|                .|...|...|
Human   610 LTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTG 674

  Fly   387 ASGADMDGDVDIEGETDADYQCHVCHKSFPRRRDLQRHMETRH 429
            |.                .:.|..||.|...:::|:.|:..||
Human   675 AK----------------PFACEYCHFSTRHKKNLRLHVRCRH 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	KREPA	<250..>352	CDD:483960	21/104 (20%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-C2H2	406..427	CDD:395048	6/20 (30%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..442
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	6/22 (27%)
		zf-H2C2_2	509..534	CDD:463886	4/24 (17%)
		zf-H2C2_5	523..546	CDD:404746	3/22 (14%)
		C2H2 Zn finger	529..545	CDD:275370	2/15 (13%)
		C2H2 Zn finger	564..584	CDD:275368	5/40 (13%)
		zf-H2C2_2	576..601	CDD:463886	7/45 (16%)
		C2H2 Zn finger	592..612	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..672	CDD:275368	2/20 (10%)
		C2H2 Zn finger	680..699	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..763
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1099	CDD:404746
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:463886
		C2H2 Zn finger	1105..1126	CDD:275368