DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prdm13 and ZNF335

DIOPT Version :9

Sequence 1:NP_648032.1 Gene:Prdm13 / 38713 FlyBaseID:FBgn0035687 Length:465 Species:Drosophila melanogaster
Sequence 2:NP_071378.1 Gene:ZNF335 / 63925 HGNCID:15807 Length:1342 Species:Homo sapiens


Alignment Length:303 Identity:59/303 - (19%)
Similarity:93/303 - (30%) Gaps:102/303 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 PFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHL------------ALGCG-RSAMDILWMRLHYA 219
            |.|.|        ::|.:|...|.:...|:.|:            .|.|. ||..   |..|...
Human   460 PLLRP--------FLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRR---WSSLKEH 513

  Fly   220 L---------KAAARSHTETQHSPIPATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMVP 275
            :         |....|:|......:...::..|......|.|  .|:.|:|           ..|
Human   514 MFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDP--TPKLSSF-----------PCP 565

  Fly   276 VTTAATPLSYLPSMSMATAPLSTNPMNAAAQIEAIVSNMGASKQGHLCIYCGKVYSRKYGLKIHI 340
            |.....|:....:..|.|                     .::::.|:|..|||.:.::|..|:|:
Human   566 VCGRVYPMQKRLTQHMKT---------------------HSTEKPHMCDKCGKSFKKRYTFKMHL 609

  Fly   341 RTH---TGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHP----------------SSSAGVADGG 386
            .||   ...:..||:||.....|...|..|...|:...|                .|...|...|
Human   610 LTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTG 674

  Fly   387 ASGADMDGDVDIEGETDADYQCHVCHKSFPRRRDLQRHMETRH 429
            |.                .:.|..||.|...:::|:.|:..||
Human   675 AK----------------PFACEYCHFSTRHKKNLRLHVRCRH 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prdm13NP_648032.1 COG5048 280..>380 CDD:227381 23/118 (19%)
C2H2 Zn finger 323..343 CDD:275368 7/19 (37%)
zf-H2C2_2 336..358 CDD:290200 8/24 (33%)
C2H2 Zn finger 351..371 CDD:275368 6/19 (32%)
zf-C2H2 406..427 CDD:278523 6/20 (30%)
C2H2 Zn finger 408..427 CDD:275368 6/18 (33%)
ZNF335NP_071378.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..102
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..442
C2H2 Zn finger 467..487 CDD:275368 5/19 (26%)
C2H2 Zn finger 497..517 CDD:275368 6/22 (27%)
zf-H2C2_2 509..534 CDD:290200 4/24 (17%)
C2H2 Zn finger 529..545 CDD:275370 2/15 (13%)
C2H2 Zn finger 564..584 CDD:275368 5/40 (13%)
zf-H2C2_2 577..600 CDD:290200 7/43 (16%)
zf-C2H2 590..612 CDD:278523 8/21 (38%)
C2H2 Zn finger 592..612 CDD:275368 7/19 (37%)
C2H2 Zn finger 623..643 CDD:275368 6/19 (32%)
C2H2 Zn finger 651..672 CDD:275368 2/20 (10%)
C2H2 Zn finger 680..699 CDD:275368 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..763
PRK04654 <795..911 CDD:135173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1013
C2H2 Zn finger 1021..1041 CDD:275368
Involved in the interaction with CCAR2. /evidence=ECO:0000269|PubMed:19131338 1041..1342
C2H2 Zn finger 1049..1069 CDD:275368
zf-H2C2_5 1075..1097 CDD:290620
C2H2 Zn finger 1077..1097 CDD:275368
zf-H2C2_2 1089..1114 CDD:290200
C2H2 Zn finger 1105..1126 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24403
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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