DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and znf513a

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001296396.1	Gene:	znf513a / 568216	ZFINID:	ZDB-GENE-030131-9895	Length:	548	Species:	Danio rerio

Alignment Length:	342	Identity:	75/342 - (21%)
Similarity:	114/342 - (33%)	Gaps:	108/342 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 PFLTPL---------NIQ-------GNSRYMCHLCHLTFETPHPLK----IHLALGCGRS-AMDI 211
            |:..||         |:|       |...|.|:.|.....:...||    :|..:|.|:| ...:
Zfish   202 PYGCPLCSYASAQLVNLQRHLRIHTGEKPYKCNTCTFACSSLGNLKRHQRMHATIGPGQSVTQPV 266

  Fly   212 LWMRLHYALKAAARSHTETQHSPIPATSSTSSASPTH---------------------------- 248
            ....|:::  .||:...|...:|.....:..|.:..|
Zfish   267 SGNGLNHS--TAAQKEKEAVPAPTEVAGAVRSVTRPHMGRDGNYLQTFDGLRLAQQTSTGVLQSG 329

  Fly   249 ---SPPPQMPPRFSAF----------------RPIAALTQSLPMVPVTTAATPLSYLPSM-SMAT 293
               |.|..:||.|..|                ..|.|.. :|.|:...|...|......: :.|.
Zfish   330 QAASQPAALPPMFFPFTCRLCGMALDDEDGSSAQICAKC-TLEMLTKDTHGCPAERGDKVYTCAA 393

  Fly   294 APLSTN-PMNAAAQIEAIVSNMGASKQGHLCIYCGKVYSRKYGLKIHIRTHTGFKPLKCKFCLRP 357
            .|..|: |.:.|..::.     .:.::.:.|..|....:....||.|.|.|||.||.||..|...
Zfish   394 CPFLTHYPNHLARHMKT-----HSGEKPYKCPQCDYASAHFDNLKRHHRVHTGEKPYKCHLCDYA 453

  Fly   358 FGDPSNLNKHVRLHLQTHPSSSAGVADGGASGADMDGDVDIEGETDADYQCHVCHKSFPRRRDLQ 422
            .|:.:||.:|.|:|                |||             ..:||.:|:.|..:..:|:
Zfish   454 CGNLANLKRHQRVH----------------SGA-------------KPFQCAICNYSCNQSMNLK 489

  Fly   423 RHMETRHGGHHSHSHSE 439
            ||| .||.|...|...|
Zfish   490 RHM-LRHTGEKPHKCQE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	26/101 (26%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	336..358	CDD:290200	12/21 (57%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-C2H2	406..427	CDD:278523	8/20 (40%)
		C2H2 Zn finger	408..427	CDD:275368	7/18 (39%)
znf513a	NP_001296396.1	C2H2 Zn finger	177..197	CDD:275368
		zf-H2C2_2	189..214	CDD:290200	3/11 (27%)
		COG5048	201..>503	CDD:227381	74/338 (22%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	217..242	CDD:290200	6/24 (25%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	5/24 (21%)
		zf-H2C2_2	403..428	CDD:290200	3/29 (10%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		zf-H2C2_2	431..454	CDD:290200	12/22 (55%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..484	CDD:290200	12/53 (23%)
		C2H2 Zn finger	475..495	CDD:275368	7/20 (35%)
		zf-H2C2_2	487..510	CDD:290200	9/20 (45%)
		C2H2 Zn finger	503..523	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100