DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and ZFP64

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_060667.2	Gene:	ZFP64 / 55734	HGNCID:	15940	Length:	681	Species:	Homo sapiens

Alignment Length:	302	Identity:	75/302 - (24%)
Similarity:	106/302 - (35%)	Gaps:	85/302 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LTPLNIQGNSRYMCHLCHLTFETPHPLKIHLALGC---GRSAMDILWMRLHYALKAAARSHTETQ 231
            |||      ..::|.:|...|........|...||   |.||             ||..:.....
Human    26 LTP------DIHICGICKQQFNNLDAFVAHKQSGCQLTGTSA-------------AAPSTVQFVS 71

  Fly   232 HSPIPATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMVPVTTAATP--------LSYLPS 288
            ...:|||.:.::.                 |.|.:.||::      |.:.|        .:|||:
Human    72 EETVPATQTQTTT-----------------RTITSETQTI------TVSAPEFVFEHGYQTYLPT 113

  Fly   289 MS------------------MATAPLSTNPMNA---AAQIEAIVS--------NMGASKQGHLCI 324
            .|                  ..|.|.:...:|.   ..|.:....        .:....:.|.|.
Human   114 ESNENQTATVISLPAKSRTKKPTTPPAQKRLNCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCE 178

  Fly   325 YCGKVYSRKYGLKIHIRTHTGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHPSSSAGVADGGASG 389
            .|||.:|||..||.|:|.|||.||.|||.|.....|.|:||||:|:|....|...........:.
Human   179 VCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNS 243

  Fly   390 ADMDGDVDIEGET-DADYQCHVCHKSFPRRRDLQRHMETRHG 430
            :.:  .|.:...| ||.:||.:|...|....||:|||....|
Human   244 SQL--TVHLRSHTGDAPFQCWLCSAKFKISSDLKRHMRVHSG 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	39/136 (29%)
		C2H2 Zn finger	323..343	CDD:275368	11/19 (58%)
		zf-H2C2_2	336..358	CDD:290200	13/21 (62%)
		C2H2 Zn finger	351..371	CDD:275368	10/19 (53%)
		zf-C2H2	406..427	CDD:278523	9/20 (45%)
		C2H2 Zn finger	408..427	CDD:275368	8/18 (44%)
ZFP64	NP_060667.2	COG5048	<151..450	CDD:227381	45/135 (33%)
		zf-H2C2_2	161..186	CDD:290200	5/24 (21%)
		C2H2 Zn finger	177..197	CDD:275368	11/19 (58%)
		zf-H2C2_2	190..211	CDD:290200	13/20 (65%)
		C2H2 Zn finger	205..225	CDD:275368	10/19 (53%)
		zf-H2C2_2	217..239	CDD:290200	7/21 (33%)
		C2H2 Zn finger	233..253	CDD:275368	1/21 (5%)
		C2H2 Zn finger	261..281	CDD:275368	8/19 (42%)
		zf-H2C2_2	273..297	CDD:290200	6/11 (55%)
		C2H2 Zn finger	289..308	CDD:275368
		C2H2 Zn finger	373..391	CDD:275368
		zf-C2H2_6	425..450	CDD:290623
		C2H2 Zn finger	427..447	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100